Triterpenes and Coumaroyltyramide from Ochthocosmus <i>Africanus</i>

Abstract

Chemical investigation of the stem bark of Ochthocosmus africanus resulted in the isolation of one new triterpene, ochtofridelane (1) along with four known compounds including stigmasterol (2), N-p-trans-coumaroyltyramine (3) and taraxerol (4), the structure of these compounds was established by analysis of their spectra and by comparison of their data with those published in the literature. To the best of our knowledge, it is the first report of chemical constituents of Ochthocosmus genus.

Chemical constituents and bioactivities of the leaves and stems of pseuduvaria fragrans

“…Based on these spectral data and comparison with previous reports (Sipowo et al, 2017) compound PF-7 was identified as N-trans-coumaroyltyramine [32].…”

“…[32], an amide alkaloid, has been found in Celtis Africana (Al-Taweel et al, 2012), allium bakeri (Okuyama et al, 1986), Allium fistulosum (Seo et al, 2011), Ochthocosmus africanus (Sipowo et al, 2017). This compound showed effective inhibition against platelet aggregation induced by adenosine 5'-diphosphate (Okuyama et al, 1986), antioxidant, anti-inflammatory, acetylcholinestrease inhibitory activity (Al-Taweel et al, 2012) and inhibition of αglucosidase activity (IC 50 = 0.42 µM) (Song et al, 2016).…”