Triterpenes and other Metabolites from Tibouchina urvilleana

Pérez-Castorena, Ana-Lidia

doi:10.29356/jmcs.v58i2.181

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…During the capture and neutralization of oxidizing species, phenolic compounds form stable intermediates without causing damage to cell structures due to the resonance of the aromatic ring present in these compounds (Soares, 2002). Other studies, with different types of metabolites, triterpenes, flavonoids and steroids, isolates of Tibouchina granulosa for Pérez-Castorena (2014)…”

Section: Discussionmentioning

confidence: 99%

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

et al. 2022

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Plants possess a renewable source of metabolites with enormous chemical structural diversity, which may have potential therapeutic relevance. Furthermore, this chemical diversity favors the possibility of finding new and different chemical constituents with antimicrobial, antioxidant and anti-tumor activities. This work analyzed preliminary phytochemical profiles and evaluated the antimicrobial, antioxidant and cytotoxic activities of hexane extracts of leaves of ten species of the family Melastomataceae. Phytochemical screening was performed using staining methods while total phenols and flavonoids were quantified by spectrophotometry. Antimicrobial activity was evaluated using the disk diffusion method. Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazil (DPPH) method. Toxicity was recorded using the lethality test with Artemia salina Leach (1819). Cytotoxic activity of the extracts was assessed in vitro with acute monocytic leukemia cells (THP-1). Phytochemical analysis detected the presence of tannins, terpenes, steroids, polyphenols and flavonoids and the absence of alkaloids. Clidemia capitellata (Bonpl.) D. Don had the greatest amount of polyphenols (205.95 mg/g ± 4.14) while Clidemia hirta (L.) D. Don had the highest content of total flavonoids (143.99 mg/g ± 4.18). The hexane extracts did not show antimicrobial activity nor toxicity against Artemia salina. The extract of Tibouchina francavillana Cogn. was the most active in sequestering the DPPH radical. The extracts showed cytotoxicity in THP-1 cells with the appearance of apoptotic bodies and cell death. The extracts of Miconia amoena, Clidemia sericea and Clidemia capitellata are non-toxic against Artemia salina and induce the formation of apoptotic bodies and cell death of the THP-1 lineage.

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Section: Discussionmentioning

confidence: 99%

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

et al. 2022

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“…Taraxastane, (18alpha,19alpha,20beta)-ursane, was the subject of a very recent study published by Hu et al who investigated its anticancer potential against DoTc2 human cervical cancer cells; the antiproliferative and selective concentration-dependent activity of taraxastane was reported, presumably through increasing ROS concentration and decreasing mitochondrial membrane potential ( 72 ). Unlike other previously studied pentacyclic triterpenes, taraxastane did not induce cell apoptosis but cell necrosis, as suggested by constant levels of Bax and Bcl-2 proteins; additionally, taraxastane blocked the JNK/MAPK signaling pathway by preventing JNK phosphorylation in a dose-dependent manner and inhibited cell migration and invasion, thus preventing metastasis.…”

Section: Triterpenes As Therapeutic Agents In Sex Hormone-dependent Cmentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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“…Cogn, whereas other derivatives of malvidin and malvidin 3‐( p ‐coumarylglucoside)‐5‐acetylxyloside stood out as major anthocyanins of Tibouchina lepidota (Bonpl.) Baill (Hendra & Keller, 2016), and T. urvilleana (Pérez‐Castorena, 2014), respectively. Peonidin 3‐sophoroside, peonidin 3‐sambubioside, malvidin 3,5‐diglucoside, and malvidin 3‐( p ‐coumaroyl)‐sambubioside‐5‐glucoside were identified in Tibouchina ciliaris (Vent.)…”

Section: Introductionmentioning

confidence: 99%

“…In terms of the potential health‐enhancing properties, some antioxidant properties and biological activities, commonly related to the pigment profile, have been ascribed to these edible flowers. Among them, it is noteworthy the antimicrobial activity of the leaves of Tibouchina candolleana (Durães Vieira et al ., 2019), antioxidant and anti‐inflammatory activities of Tibouchina pulchra and Tibouchina granulosa (Esposito & Domingos, 2014; Sobrinho et al ., 2017), and anti‐inflammatory activities of Tibouchina urvilleana (Pérez‐Castorena, 2014; Gowthami & Naga Lakshmi, 2021). Further health‐related properties as anti‐leishmanial, anti‐inflammatory, and antimicrobial activities were ascribed to Tibouchina paratropica (Tracanna et al ., 2015) and antioxidant activity and cytotoxicity in THP‐1 cell parasitic activity to Tibouchina francavillana and Tibouchina lhotzkyana (Bomfim et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

First accurate profiling of antioxidant anthocyanins and flavonols of Tibouchina urvilleana and Tibouchina mollis edible flowers aided by fractionation with Amberlite XAD‐7

Solarte

Cejudo‐Bastante

Hurtado

et al. 2022

Int J of Food Sci Tech

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Summary A purification and fractionation process of the edible flowers of Tibouchina mollis and Tibouchina urvilleana followed by the first attempt to the anthocyanin and flavonol characterisation and identification by UHPLC‐DAD‐ESI‐MS were developed. T. urvilleana exhibited a higher monomeric anthocyanin content, mainly due to the presence of the 3‐O‐(6′‐p‐coumaroyl)‐glucoside derivatives of malvidin and petunidin. Quercetin‐3‐O‐hexoside was the major flavonol identified in T. urvilleana, and the lack of myricetin derivatives was also exhibited. The anthocyanin and flavonol profile of T. mollis was more miscellaneous, characterised by the occurrence of cyanidin‐3‐O‐glucoside followed by the 3‐O‐(6′‐p‐coumaroyl)‐glucoside and 3‐O‐glucoside derivatives of malvidin and petunidin as anthocyanins, and myricetin, quercetin, and 3‐O‐hexosides of kaemperol and quercetin as flavonol compounds. Therefore, the anthocyanin and flavonol profile, through a process based on purification and fractionation, could be a useful tool to ensure the authenticity of the Tibouchina. Furthermore, the purification process made the antioxidant activity increase, which is greatly correlated to the reduction capacity.

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Triterpenes and other Metabolites from Tibouchina urvilleana

Cited by 6 publications

References 15 publications

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

Phytochemical composition and biological activities of extracts from ten species of the family Melastomataceae Juss

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

First accurate profiling of antioxidant anthocyanins and flavonols of Tibouchina urvilleana and Tibouchina mollis edible flowers aided by fractionation with Amberlite XAD‐7

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