Triterpenes of Commiphora holtziana oleo-gum resin

Abstract

Chemical analysis of the acetone extract of Commiphora holtziana gum resin has led to the isolation of triterpenes characterized as methyl 3-oxo-1α,19α,28-trihydroxyurs-12-en-24-oate (1), methyl 3β-acetyl-2α,11α,19α,28-tetrahydroxyurs-12-en-24-oate (2), methyl 3β,11α-diacetyl-1α,2α,28-trihydroxyurs-12-ene-24-oate (3), and 3β,28-diacetyl-1α,2α,25-trihydroxydammar-23-ene (4). The known compounds isolated from the same extract included cabraleadiol monoacetate (5), mansumbinol (6), 3β-acetylamyrin (7), 3α-acetylboswellic acid (8), 2-methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one (9), 2-methoxy-5-acetylfuranogermacra-1(10),7,11-trien-6-one (10), furadienone (11), 2-methoxy-5-acetyl-4-furanogermacra-1(10)Z-en-6-one (12), α-amyrin (13), sistosterol (14) and stigmasterol 3-O-acetate (15). Structural elucidation was carried out using spectroscopic and physical methods as well as by comparison with the literature data.

beta-Amyrin and alpha-amyrin acetate isolated from the stem bark ofAlstonia booneidisplay profound anti-inflammatory activity

“…Similarly, all the proton and carbon signals were assigned based on the 1 H 1 HCOSY, DEPT analysis, and HMQC and HMBC data as shown in Table 1. Compound 2 was thus identified as 3b-acetoxyurs-12-ene (a-amyrin acetate) (Figure 1) and the spectral data compared favorably well with those previously reported (Ali, 2013;Dias et al, 2011;Manguro et al, 2009;Sob et al, 2010). Both compounds were used for the xylene-induced mouse ear edema test and membrane stabilization effect, while only compound 2 (a-amyrin acetate) was used for the egg albumen-induced rat paw edema test, ulcerogenic effect and effect on in vivo leukocyte migration.…”

Investigation of Antiplasmodial Effects of Terpenoid Compounds Isolated from Myrrh

“…4. Several previous papers report on the isolation of rather unusual nortriterpenoids with a C-22 backbone, the mansumbinanes, from different Commiphora species [29][30][31]. Mansumbinanes are probably derived from dammaranes [32], so that the dammarane numbering system is applied for their structures.…”

Isolation and Characterisation of an Αlpha-amyrin Acetate Isolated from the Leaves of Microtrichia perotitii DC (Asteraceae)

“…α-amyrin acetate have been reported to possess analgesic and antiinflammatory properties and could therefore be responsible for the analgesic and antiinflammatory activities of the herb as well being responsible for some of the ethanomedicinal applications of the herb. Other significant activities of α-amyrin acetate include; antioxidant, sedative, anti-pyretic, anticonvulsant and anti-bacterial properties [26,41,38,42,43,44,45,46,47,48], anti-erectile dysfunction effects, growth inhibitory effect on Streptococcus, suppressive effects on male albino rat fertility, antihyperglycaemic, larvicidal, cytotoxic and antispasmodic, apoptosis of leukemia cells, antihepatoxic and antioxidant properties.…”