Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

Pérez, Andy J.; Hassan, Emad M.; Pecio, Łukasz; Omer, Elsayed A.; Kucińska, Małgorzata; Murias, Marek; Stochmal, Anna

doi:10.1016/j.phytol.2015.05.013

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…Erythrina abyssinica HIV/AIDS (Lamorde et al, 2010), vomiting (Tugume et al, 2016); Burundi: cough (Rodegem, 1970), eyes, strenghtens breastmilk, female sterility, cough, epistaxis, depression, protection black magic (Baerts and Lehmann, 1989); central Africa: stomach problems (Balagizi et al, 1998); Congo: eye inflammation, snake bitse, antihelmentic, diphtheria (Defour, 1994), tuberculosis, eye inflammation (Cihyoka, 1994), wounds (Byavu et al, 2000, hemorrhoids (Nyakabwa and Dibaluka, 1990); Kenya: wounds, dermatosis, boils (Kokwaro, 1987), internal pain (Glover et al, 1966); Kenya/Uganda/Tanzania: snake bite, gonorrhea, syphilis, collique, stomach ache (Kokwaro, 1976); Rwanda: eye inflammation (Desouter, 1991), wounds, snake bites, lepre (Durand, 1960), dysentery, meningitis, jaundice Habiyaremye, 1987), hemorrhoids (Ayobangira et al, 2000); Tanzania: stomach pain (Chabra et al, 1990); Uganda: candide (Hamil et al, 2000), epilepsy (Adjanohoun et al, 1993); Zimbabwe: cough, rougeole, bilharziose, cachexie, psychose (Gelfand et al, 1985) Anticancer (Samanga et al, 2014), wound healing properties (Marume et al, 2017), prevents meningoencephalitis (Nasimolo et al, 2014), antimicrobial (Kamat et al, 1981), antibacterial (Nguyen et al, 2016;Wagate et al, 2010), antimalariall (Yenesew et al, 2004), antihyperglycemic (Amuri et al, 2017), anti-HIV, antiviral (Mohammed et al, 2012), antidiabetic (Cui et al, 2010, antifungal (Manyarara et al, 2016) cytotoxic (Perez et al, 2015), antimycobacterial (Bunalema et al, 2011)…”

Section: Englerophytum Magalismontanummentioning

confidence: 99%

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

Novotná

Polesny

Pinto-Basto

et al. 2020

Journal of Ethnopharmacology

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Section: Englerophytum Magalismontanummentioning

confidence: 99%

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

Novotná

Polesny

Pinto-Basto

et al. 2020

Journal of Ethnopharmacology

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“…Based on the chemical structure of the isolated flavonoids, they can be grouped into 17 groups as shown in Table 2 [3, 5]. The isolated Erythrina flavonoid compounds along with the extraction solvents and isolation and purification techniques are arranged alphabetically according to the names of the compounds in Table S1 [49–192]. The diversity of this flavonoid framework consists of 25 flavones (1–25), four flavanols (26–29), 103 flavanones (30–132), 16 chalcones (133–148), 12 isoflavans (149–160), eight isoflav‐3‐enes (161–168), 55 isoflavanones (169–223), 1011 isoflavones (224–324), 72 pterocarpans, 6α‐hydroxypterocarpans, and pterocarpenes (325–396), five coumestans (397–401), four 3‐arylcoumarins (402‐405), one coumaronochromones (406), 20 2‐arylbenzofurans and 3‐aryl‐2,3‐dihydrobenzofurans (407–426), and one bioflavonoids (427) (Table 2).…”

Section: Flavonoids Contained In the Genus Erythrinamentioning

confidence: 99%

“…In a phytochemical study using the 70% ethanol extract of E. abyssinica root bark, four new flavone glycosides were obtained, namely abyssinoside A (10) , abyssinoside B (11) , abyssinoside C (12) , and abyssinoside D (13) , through repeated cycles of CC on silica gel, Sephadex LH‐20, and sequential HPLC technique. The glycosidation of compounds 11−13 occurs in the C‐glycosylation section at H‐6 and H‐8 in the A ring [52]. Glycosidation of flavonoids was also found in the new flavone compound 5,7,4′‐trihydroxy‐3′‐methoxyl‐8‐C‐prenylflavone 7‐O‐β‐D‐(1→3)‐α‐L‐arabinopyranoside (25) , which was successfully isolated from the 95% ethanol extract of E. indica seeds, where MS and NMR data and acid hydrolysis analysis showed that glycosylation and prenylation occur at the C‐7 and C‐8 carbons of this flavone, respectively [53].…”

Section: Concluding Remarks and Future Prospectsmentioning

confidence: 99%

An overview of techniques and strategies for isolation of flavonoids from the genus Erythrina

Rahmawati

Hartati

Latip

et al. 2023

J of Separation Science

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Plants in the genus Erythrina is a potential source of chemical constituents, one of which is flavonoids, which have diverse bioactivities. To date, literature on the flavonoids from the genus Erythrina has only highlighted the phytochemical aspects, so this review article will discuss isolation techniques and strategies for the first time. More than 420 flavonoids have been reported in the Erythrina genus, which are grouped into 17 categories. These flavonoid compounds were obtained through isolation techniques and strategies using polar, semi‐polar, and non‐polar solvents. Various chromatographic techniques have been developed to isolate flavonoids using column flash chromatography, quick column chromatography, centrifugally accelerated thin‐layer chromatography, radial chromatography, medium‐pressure column chromatography, semi‐preparative high‐performance liquid chromatography, and preparative high‐performance liquid chromatography. Chromatographic processes for isolating flavonoids can be optimized using multivariate statistical applications such as response surface methodology with central composite design, Box–Behnken design, Doehlert design, and mixture design.

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“…ree sesquiterpenes, 3,6caryolanediol ( 115) and clovane-2,9-diol (116) along with caryolane-1,9-diol (96), were isolated from E. abyssinica roots [134]. On the other hand, two new triterpenoids, abyssaponin A (97) and abyssaponin B (97) along with a triterpenoid saponin, soyasapogenol B (99), were isolated from E. abyssinica stem bark [147].…”

Section: Evidence-based Complementary and Alternative Medicinementioning

confidence: 99%

“…Chloroform extract of the whole plant had bioactivity against S. aureus, with 7. 45 [147]. e mechanisms by which these phytochemicals mediated their anticancer activity were however not elucidated.…”

Section: In Vitro Antidiarrheal Activitymentioning

confidence: 99%

Traditional Medicinal Uses, Phytoconstituents, Bioactivities, and Toxicities of Erythrina abyssinica Lam. ex DC. (Fabaceae): A Systematic Review

Obakiro

Kiprop

Kigondu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Many studies have been undertaken on the medicinal values of Erythrina abyssinica Lam. ex DC. (Fabaceae). The details, however, are highly fragmented in different journals, libraries, and other publication media. This study was therefore conducted to provide a comprehensive report on its ethnobotany, ethnomedicinal uses, phytochemicals, and the available pharmacological evidence supporting its efficacy and safety in traditional medicine. Method. We collected data using a PROSPERO registered systematic review protocol on the ethnobotany, phytochemistry, and ethnopharmacology of Erythrina abyssinica from 132 reports that were retrieved from electronic databases. Documented local names, morphology, growth habit and habitat, ethnomedicinal and nonmedicinal uses, diseases treated, parts used, method of preparation and administration, extraction and chemical identity of isolated compounds, and efficacy and toxicity of extracts and isolated compounds were captured. Numerical data were summarized into means, percentages, and frequencies and presented as graphs and tables. Results. Erythrina abyssinica is harvested by traditional herbal medicine practitioners in East, Central, and South African communities to prepare herbal remedies for various human and livestock ailments. These include bacterial and fungal infections, tuberculosis, malaria, HIV/AIDS, diarrhea, cancer, meningitis, inflammatory diseases, urinary tract infections, wounds, diabetes mellitus, and skin and soft tissue injuries. Different extracts and phytochemicals from parts of E. abyssinica have been scientifically proven to possess anti-inflammatory, antibacterial, antioxidant, antiplasmodial, antiproliferative, antifungal, antimycobacterial, antidiarrheal, anti-HIV 1, antidiabetic, and antiobesity activities. This versatile pharmacological activity is due to the abundant flavonoids, alkaloids, and terpenoids present in its different parts. Conclusion. Erythrina abyssinica is an important ethnomedicinal plant in Africa harboring useful pharmacologically active phytochemicals against various diseases with significant efficacies and minimal toxicity to mammalian cells. Therefore, this plant should be conserved and its potential to provide novel molecules against diseases be explored further. Clinical trials that evaluate the efficacy and safety of extracts and isolated compounds from E. abyssinica are recommended.

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Triterpenoid saponins and C-glycosyl flavones from stem bark of Erythrina abyssinica Lam and their cytotoxic effects.

Cited by 17 publications

References 31 publications

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

An overview of techniques and strategies for isolation of flavonoids from the genus Erythrina

Traditional Medicinal Uses, Phytoconstituents, Bioactivities, and Toxicities of Erythrina abyssinica Lam. ex DC. (Fabaceae): A Systematic Review

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