Triterpenoid saponins from Ferula hermonis Boiss

This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-resin (OGR) and the non-volatile fractions obtained from several endemic and indigenous Ferula species is also reported. A special emphasis is placed on their unusual components, i.e. sulfur-containing volatiles from the EOs and the new phytochemicals with mixed biogenetic origins. More than 180 chemical constituents (excluding common essential oils components), including sulfur-containing metabolites, terpenoids, coumarins, sesquiterpene coumarins, etc., as both aglycones and glycosides, are reported, along with their occurrence and biological activities when available. A large number of new secondary metabolites, belonging to different classes of natural products possessing interesting biological activities, from the antiproliferative to the anti-inflammatory to the neuroprotective ones, among the others, have been recently found in the Ferula genus. Several of these phytochemicals are exclusive to this genus; therefore may be considered chemotaxonomic markers. All these aspects are extensively discussed in this review.

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“…51. The molecular structure of the saponin (sandrosaponin XI) (184) isolated from the root of F. hermonis Boiss (Ibraheim et al, 2012b)…”

mentioning

confidence: 99%

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Mohammadhosseini

Venditti

Sarker

et al. 2019

Industrial Crops and Products

129

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“…Phytochemical investigations of Ferula species have been focused on their sesquiterpenes and coumarins with little attention paid to other compounds. In 2012, Ibraheim [25] reported the isolation of three new triterpenoid saponins including 18 (sandrosaponin X), 19 (sandrosaponin IX) and 20 (sandrosaponin XI) (20), for the first time from F. hermonis (▶ Fig.2).…”

Section: Other Compoundsmentioning

confidence: 99%

“…The chemistry of Ferula species has been studied by many research groups and various compounds including sulfur-containing compounds, sesquiterpenes, sesquiterpene coumarins and sesquiterpene coumarin glycosides have been identified in Ferula species [2,[11][12][13][14][15][16][17]. Phytochemical studies on F. hermonis roots and seeds, showed the presence of various sesquiterpenes including daucane-type sesquiterpenes [6,9,[18][19][20][21][22][23][24], terpenoidal saponins [25] and volatile constituents. Terpenoidal saponins which have been isolated and characterized from F. hermonis, belong to the oleanane class of C 30 saponins.…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry and Pharmacology of Ferula hermonis Boiss. – A Review

Sattar

Iranshahi

2017

Drug Res (Stuttg)

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Ferula hermonis, a well-known species of the genus Ferula found in Lebanon and Syria, has a brilliant history in traditional medicine as it has been used for the treatment of erectile dysfunction in men and menopausal disturbances in women. Thanks to modern pharmacological and clinical investigations, is a valuable medicinal and condimental plant that may be used for the treatment of impotence and diabetes, the prevention of osteoporosis, and possesses anti-microbial and anti-inflammatory properties. Phytochemical investigations have shown that this plant contains daucane aryl esters such as ferutinin, which has exhibited various biological activities including hypoglycemic and estrogenic activities. Ferutinin is one of the strongest natural phytoestrogen which has agonistic activity on estrogen receptors, particularly α receptor. It seems that ferutinin and its derivatives play an important role in biological activities, mainly the beneficial effects of this plant on impotence, diabetes and osteoporosis. The present review discusses the available data on the active constituents and biological activities of and their possible underlying mechanisms of action.

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“…β-Sitosterol (α-dihydrofucosterol) (31) is the most abundant phytosterol on human diet and possess significant effect in relieving menopausal symptoms and reducing blood cholesterol levels by blocking the intestinal uptake. [86][87][88] Encountered in leaves, flowers and fruits, largely distributed throughout the Plantae kingdom, [89][90][91] this metabolite has a similar structure to estradiol and cholesterol, showing important anti-inflammatory and analgesic properties, [92][93][94] as well as antitumoral effects, such as minimizing symptoms of prostatic hyperplasia. 95 In recent study, it also has a significant concentrationdependent inhibition against induced-Epstein-Barr virus antigen, at low toxicity rates.…”

Section: Steroidsmentioning

confidence: 99%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms.

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Triterpenoid saponins from Ferula hermonis Boiss

Cited by 7 publications

References 37 publications

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Phytochemistry and Pharmacology of Ferula hermonis Boiss. – A Review

Update: Biological and Chemical Aspects of Senna spectabilis

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