Triterpenoid saponins from Impatiens siculifer

Li, Wei; Bi, Xue-yan; Wang, Kun; Li, Dongxia; Satou, Tadaaki; Koike, Kazuo

doi:10.1016/j.phytochem.2009.03.022

Cited by 19 publications

(8 citation statements)

References 13 publications

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“…gaumeri exerted cytotoxic activity (IC 50 11.9 μg ml −1 ) against the murine macrophage-like cell line RAW 264.7 (Sánchez-Medina et al 2009). Moderate activity against human leukemia HL-60, stomach adenocarcinoma KATO-III and lung adenocarcinoma A549 cells, was also reported for echinocystic acid bidesmoside, impatienoside G (IC 50 21.8–36.7 μmol l −1 ) (Li et al 2009). However, other compounds tested in this study, including mono- and bidesmosides of soyasapogenol A were inactive at concentrations 50 μmol l −1 .…”

Section: Correlation Between the Structure And Cytotoxicity Of Saponinsmentioning

confidence: 79%

Saponins as cytotoxic agents: a review

2010

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Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005–2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.

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Section: Correlation Between the Structure And Cytotoxicity Of Saponinsmentioning

confidence: 79%

Saponins as cytotoxic agents: a review

2010

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“…The structures of these isolated compounds were established through analysis of their NMR and FABMS spectra, which enabled the characterization of compounds 7 and 10 as novel and compounds 1-6, 8 and 9 as known. Spectra for known saponins confirmed their structures to be dehydrosoyasaponin IV methyl ester (1), 4 dehydrosoyasaponin III (impatienoside A) methyl ester (2), 4 soyasaponin III methyl ester (3), 5 dehydrosoyasaponin II (soyasaponin Bg) methyl ester (4), 4 soyasaponin II methyl ester (5), 6 dehydrosoyasaponin I (soybean saponin Be) methyl ester (6), 7,8 soyasaponin I methyl ester (8), 7,8 and kudzusaponin SA 3 methyl ester (9).…”

Section: Resultsmentioning

confidence: 98%

“…2, 3 The isolation of soyasaponins was limited to soy and other leguminous plants 2,3 and Impatiens siculifer 4 (Balsaminaceae) to date. Therefore, the presence of soyasaponins in the liquid cultured mycelia of G. applanatum seems to be an unusual feature.…”

Section: Introductionmentioning

confidence: 99%

Soyasaponins from Soybean Flour Medium for the Liquid Culture of Ganoderma applanatum

Lee¹,

Kim²,

Shim³

et al. 2011

Bulletin of the Korean Chemical Society

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Two new unusual soyasaponins named 6''-O-methyldehydrosoyasaponin I (7) and desglucosylsoyasaponin A 1 (10) along with eight known saponins, dehydrosoyasaponin IV (1), dehydrosoyasaponin III (= impatienoside A) (2), soyasaponin III (3), dehydrosoyasaponin II (= soyasaponin Bg) (4), soyasaponin II (5), dehydrosoyasaponin I (= soyasaponin Be) (6), soyasaponin I (8), and kudzusaponin SA 3 (9), were isolated as their methyl esters and identified from the liquid culture of G. applanatum. Their structures were determined by chemical and spectroscopic analyses including 1D-and 2D-NMR as well as by comparison of their spectroscopic data with those of the reported in literatures. Although dehydrosoyasaponin IV was identified by LC-MS/MS method from soy protein isolate, this is the first report of the isolation of this compound. Dehydrosoyasaponin III (2) and kudzusaponin SA 3 (9) were also isolated for the first time from soybean. The presence of soyasaponins in Ganoderma species seems to be unusual feature. Thus, we presumed that compounds 1-10 might all be derived from the defatted soybean flour which was added to the culture medium as a nitrogen source.

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“…Triterpenoid saponins are the main constituents of A. gigantifolia Stapf. and many of them possess antitumor activities according to the previous studies [2,3]. We recently isolated 13 triterpenoid saponins from the rhizomes of A. gigantifolia Stapf.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation on the triterpenoid saponin ofArdisia gigantifoliabyAspergillus avenaceusAS 3.4454

Wang

et al. 2014

Journal of Asian Natural Products Research

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Compound 1, a triterpenoid saponin from Ardisia gigantifolia Stapf. showing potential anti-tumor activity, was transformed into three derivatives (2-4) by Aspergillus avenaceus 3.4454. Among them, compounds 2 and 3 are new compounds. Their structures were elucidated on the basis of 1D NMR, 2D NMR, HR-ESI-MS, and optical rotation data. Compounds 1-3 were evaluated for their cytotoxicity against human hepatocellular carcinoma and normal liver cells by cell counting kit 8 colorimetric assay. Compound 3 displayed better cytotoxicity against Bel-7402 and HepG2 cell lines and much weaker cytotoxicity against normal liver L02 cell than that of positive control (epirubicin hydrochloride).

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Triterpenoid saponins from Impatiens siculifer

Cited by 19 publications

References 13 publications

Saponins as cytotoxic agents: a review

Saponins as cytotoxic agents: a review

Soyasaponins from Soybean Flour Medium for the Liquid Culture of Ganoderma applanatum

Biotransformation on the triterpenoid saponin ofArdisia gigantifoliabyAspergillus avenaceusAS 3.4454

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