“…Structures of these compounds were assigned on the basis of spectroscopic data ( 1 H and 13 C NMR, 1 H- 1 H COSY, HSQC, HMBC, and ROESY) and by the comparison of their spectroscopic data with those reported in the literature. These compounds are: 3- O - β - d -glucuronopyranosyl-oleanolic acid ( 1 ) [31], 3- O - β - d -glucuronopyranosyloleanolic acid 28- O - β - d -glucopyranosyl ester ( 2 ) [31], 3- O - β - d -glucopyranosyl(1 → 2)- β - d -glucuronopyranosyl oleanolic acid ( 3 ) [32] and 3- O - β - d -glucopyranosyl(1 → 2)- β - d -glucuronopyranosyl oleanolic acid 28- O - β - d -glucopyranosyl ester ( 4 ) [33]. Fig.…”
The present study showed significant antimicrobial activity of compounds 1, 2, 3 and 4 against the tested microorganisms. The saponins act in synergy with the tested standard antibiotics. This synergy could lead to new options for the treatment of infectious diseases and emerging drug resistance.
“…Structures of these compounds were assigned on the basis of spectroscopic data ( 1 H and 13 C NMR, 1 H- 1 H COSY, HSQC, HMBC, and ROESY) and by the comparison of their spectroscopic data with those reported in the literature. These compounds are: 3- O - β - d -glucuronopyranosyl-oleanolic acid ( 1 ) [31], 3- O - β - d -glucuronopyranosyloleanolic acid 28- O - β - d -glucopyranosyl ester ( 2 ) [31], 3- O - β - d -glucopyranosyl(1 → 2)- β - d -glucuronopyranosyl oleanolic acid ( 3 ) [32] and 3- O - β - d -glucopyranosyl(1 → 2)- β - d -glucuronopyranosyl oleanolic acid 28- O - β - d -glucopyranosyl ester ( 4 ) [33]. Fig.…”
The present study showed significant antimicrobial activity of compounds 1, 2, 3 and 4 against the tested microorganisms. The saponins act in synergy with the tested standard antibiotics. This synergy could lead to new options for the treatment of infectious diseases and emerging drug resistance.
“…The main difference found was the linkage site of the sugar residue, which was deduced from the HMBC correlations between H-1′ (δ H 4.89) and C-3 (δ C 89.0) and between H-1″ (δ H 5.33) and C-2′ (δ C 82.4), as shown in Figure . In addition, the triterpene saponin showed similar NMR data to those of 28-deglucosylchicususoponin V except for the presence of a panaxytriol moiety . Thus, the structure of 3 was assigned as polyacetylenic 28-deglucosylchicususoponin V.…”
Section: Resultsmentioning
confidence: 69%
“…In addition, the triterpene saponin showed similar NMR data to those of 28-deglucosylchicususoponin V except for the presence of a panaxytriol moiety. 23 Thus, the structure of 3 was assigned as polyacetylenic 28-deglucosylchicususoponin V.…”
Three new polyacetylenic oleanane-type triterpenoids, baisanqisaponins A-C (1-3), and one new oleanane-type triterpenoid, chikusetsusaponin-V ethyl ester (4), together with 19 known compounds (5-23), were isolated from the roots of Panax japonicus. The structures were elucidated on the basis of spectroscopic analyses and chemical methods. Compounds 1-3 feature a rare panaxytriol group containing a polyacetylene on the saponin skeleton. Neuroprotective activity was evaluated for compounds 1-17, and angiotensin II-induced vascular smooth muscle cell proliferation inhibition was tested for compounds 5-7 and 10-12.
“…~~~ Karounidiol (317) and its 3-benzoate derivative are multifloradiene derivatives from Trichosantes k i r i l o ~i i . ~~~ The structure and C-20 configuration of karounidiol (3 17) were revealed by X-ray analysis and this result, together with NMR evidence, necessitates the revision of the C-20 configurations of bryonolic acid (318), bryononic acid (3 19), and bryocoumaric acid (320). Crystal structure analyses of two bryonolic acid derivatives have been 3-Oxofriedelan-29-dioI (32 1) has been isolated from Mortonia d z f l u s ~.…”
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