Triterpenoid Saponins From the Stem Bark of Pentaclethra eetveldeana

Pertuit, David; Kapundu, Mpuza; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Delaude, Clément; Lacaille-Dubois, M. A.

doi:10.1177/1934578x19863947

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Phytochemical studies have previously been carried out only on stem bark and roots of other species of the genus Pentaclethra. Therefore, previous studies on stem bark of P. macroloba, and P. eetveldeana led to the isolation of saponins [2] [37] [38], phenolic compounds [39] [40] [41], and fatty acid derivatives [37] [39]. Furthermore, tannins were isolated from stem bark of P. macroloba and P. macrophylla [39] [40] [41].…”

Section: Resultsmentioning

confidence: 99%

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae)

Ponou¹,

Tsafack²,

Kühlborn³

et al. 2021

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Phytochemical investigation of the seeds of Pentaclethra macrophylla led to the isolation of a mixture of two new aromatic monoterpene glycosides, pentamacrophylloside A (1a) and pentamacrophylloside B (1b), together with six known secondary metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5), 2-hydroxymethyl-5-(2-hydroxypropan-2-yl)phenol (6), and sucrose (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR), high-resolution mass spectrometry and by comparison of their spectral data with those of related compounds. The extracts and compounds 3 and 4 were screened for their antimicrobial activity. The n-BuOH fraction showed a weak effect against three microbial strains: Candida albicans (MIC: 256 µg/mL), Enterococcus faecalis (MIC: 512 µg/mL), and Proteus mirabilis (MIC: 512 µg/mL) while no significant inhibition was observed for pure compounds when compared to ketoconazole and ciprofloxacin used as references. Furthermore, the ethnobotany and pharmacology of this plant are reviewed, and the chemophenetic significance of the isolation of the above secondary metabolites is discussed. This is the first report on the isolation of aromatic monoterpenoids from a plant of the genus Pentaclethra.

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Section: Resultsmentioning

confidence: 99%

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of Pentaclethra macrophylla Benth (Mimosaceae)

Ponou¹,

Tsafack²,

Kühlborn³

et al. 2021

ABC

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“…For instance, in the Democratic Republic of Congo, Memvanga et al reported the antiplasmodial effect of the root bark of this plant [ 50 ]. In the same way, triterpenoid saponins have been isolated from its bark [ 51 , 52 ]. In particular, traditionally in the Republic of Congo, P. eetveldeana bark is used in the treatment of various respiratory tract diseases (cough, bronchitis, whooping cough, tuberculosis), in intoxications, constipation, stomach pains, hernia outbreaks, but also for genitourinary infections and various generalized pains.…”

Section: Introductionmentioning

confidence: 99%

Pentaclethra eetveldeana Leaves from Four Congo-Brazzaville Regions: Antioxidant Capacity, Anti-Inflammatory Activity and Proportional Accumulation of Phytochemicals

N’goka,

Oyegue Liabagui,

Sima Obiang

et al. 2023

Plants

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Oxidative stress and inflammation play a key role in the occurrence of neurodegenerative diseases. Traditionally, Pentaclethra eetveldeana leaves are used in dementia treatment. Therefore, this study aimed to evaluate the antioxidant and anti-inflammatory activities as well as the phytochemical composition of Pentaclethra eetveldeana leaves from four Congo-Brazzaville regions. The 1.2-diphenyl-1-picrylhydrazyl radical-scavenging, β-carotene bleaching and molybdenum reduction assays were used to assess the antioxidant activity. The protein denaturation and erythrocyte membrane stabilization tests were used to analyze the anti-inflammatory activity. Phytochemical screening, the quantification of polyphenols by spectrophotometry, as well as the determination of extraction yields were carried out. It was found that the extracts reduced molybdenum; furthermore, compared to ascorbic acid, they showed better antiradical activity and inhibited lipid peroxidation. Moreover, globally, the membrane-stabilizing power of the aqueous extracts was superior or comparable to diclofenac, while the same extracts were less effective for the inhibition of denaturation. All of the aqueous extracts contained polyphenols, saponins, alkaloids, anthraquinones, reducing sugar and cardiotonic glycosides. The total polyphenols, tannins and proanthocyanidins are produced proportionally from one region to another. Finally, the leaves from Brazzaville and Boundji contain flavonols, while those from Makoua and Owando contain flavones. Thus, Pentaclethra eetveldeana leaves contribute to traditional dementia treatment through their antioxidant and anti-inflammatory properties.

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“…Pentaclethra is a small genus of the Fabaceae family, comprising mainly three species of trees, distributed throughout subtropical and tropical regions of the world [1][2][3][4]. The species of the genus Pentaclethra, such as Pentaclethra macroloba and P. eetveldeana, have been described as medicinal plants with their biological activities assessed [3,4].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract

Nnamani,

Diovu,

Peter

et al. 2023

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Purpose: Inflammation of various degrees is common among humans. There are associated side effects with orthodox delivery systems and anti-inflammatory agents; hence, the study investigated the characteristics of herbal lipospheres and the anti-inflammatory potency of the lipospheres formulated from Pentaclethra macrophylla with the view to having a drug with a better delivery system and lesser side effects. Methods: Herbal lipospheres were formulated using solidified reverse micellar solutions (SRMS) of P90H and goat fat and characterized for particle size and morphology, pH time dependent analysis, encapsulation efficiency (EE%), and Fourier Transform infrared spectroscopy. The in vitro antinociceptive and anti-inflammatory studies were carried out using membrane stabilization by hypotonicity-induced hemolysis and the determination of anti-platelet aggregatory activity models. The in vivo antinociceptive and anti-inflammatory studies on egg albumin- and formaldehyde-induced arthritis models were conducted. A total white blood cell count and differential blood count were carried out on the rats. Results: The results showed that there was no change in pH for the PM-unloaded lipospheres and 2.5 g of PM-loaded lipospheres from day 1 to day 7, but there was a mild variation in the rest of the formulations. The EE ranged from 35.2% to 94%, increasing according to the drug concentration. The photomicrographs of the lipospheres showed that the particles were spherical in shape. The particle sizes were within the acceptable range for lipospheres. FTIR showed no interaction. In the arthritis study, PM-loaded lipospheres inhibited edema consistently throughout the duration of observation. Inhibition of the membrane increased steadily with an increase in concentration of PM in the lipospheres and the standard drug. The platelet aggregatory inhibition decreased steadily with an increase in concentration of the PM in the lipospheres as well as the standard. The T50 dose of PM had the highest percentage of WBC, and it decreased as the treatment doses increased from T100 to T200. There were no significant differences among the Neutrophil counts of the different groups. Conclusions: The study, therefore, showed that the methanol extract of Pentaclethra macrophylla formed efficient herbal lipospheres with antinociceptive and anti-inflammatory activities.

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Triterpenoid Saponins From the Stem Bark of Pentaclethra eetveldeana

Cited by 4 publications

References 10 publications

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of <i>Pentaclethra macrophylla</i> Benth (Mimosaceae)

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of <i>Pentaclethra macrophylla</i> Benth (Mimosaceae)

Pentaclethra eetveldeana Leaves from Four Congo-Brazzaville Regions: Antioxidant Capacity, Anti-Inflammatory Activity and Proportional Accumulation of Phytochemicals

Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract

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Triterpenoid Saponins From the Stem Bark of Pentaclethra eetveldeana

Cited by 4 publications

References 10 publications

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of &lt;i&gt;Pentaclethra macrophylla&lt;/i&gt; Benth (Mimosaceae)

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of &lt;i&gt;Pentaclethra macrophylla&lt;/i&gt; Benth (Mimosaceae)

Pentaclethra eetveldeana Leaves from Four Congo-Brazzaville Regions: Antioxidant Capacity, Anti-Inflammatory Activity and Proportional Accumulation of Phytochemicals

Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract

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Product

Resources

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Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of <i>Pentaclethra macrophylla</i> Benth (Mimosaceae)

Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of <i>Pentaclethra macrophylla</i> Benth (Mimosaceae)