Triterpenoid saponins from the stem barks of Chytranthus klaineanus Radlk. ex Engl

Biang, Armand Emmanuel Moffi; Kamto, Eutrophe Le Doux; Simo, Line Made; Antheaume, Cyril; Lavedan, Pierre; Vedrenne, Marc; Pegnyemb, Dieudonné Emmanuel; Mbing, Joséphine Ngo; Haddad, Mohamed

doi:10.1016/j.phytol.2020.04.006

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Although in the presence of other phytochemistry (124), saponin mixture in a single plant species occurs (120,121,125), such as cucurbitane, cycloartane, dammarane, holostane, hopane, lanostane, lupane, oleanane, tirucallane, taraxastane, tirucallane, and ursane TPS types (107,126) have been identified in more than 500 plant species (114). Within a hundred familygroup plants, the Anacardiaceae, Araliaceae, Combretaceae, Compositae Campunalaceae, Caryophyllaceae, Leguminosae, Polygalacea, Sapindaceae, Theaceae, and Verbenaceae families, their genera and species attract more attention (114,(127)(128)(129)(130)(131).…”

Section: Terpenes Biosynthesis and Functionalitymentioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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This review provides an update of ecologically relevant phytochemicals for ruminant production, focusing on their contribution to advancing nutrition. Phytochemicals embody a broad spectrum of chemical components that influence resource competence and biological advantage in determining plant species' distribution and density in different ecosystems. These natural compounds also often act as plant defensive chemicals against predatorial microbes, insects, and herbivores. They may modulate or exacerbate microbial transactions in the gastrointestinal tract and physiological responses in ruminant microbiomes. To harness their production-enhancing characteristics, phytochemicals have been actively researched as feed additives to manipulate ruminal fermentation and establish other phytochemoprophylactic (prevent animal diseases) and phytochemotherapeutic (treat animal diseases) roles. However, phytochemical-host interactions, the exact mechanism of action, and their effects require more profound elucidation to provide definitive recommendations for ruminant production. The majority of phytochemicals of nutritional and pharmacological interest are typically classified as flavonoids (9%), terpenoids (55%), and alkaloids (36%). Within flavonoids, polyphenolics (e.g., hydrolyzable and condensed tannins) have many benefits to ruminants, including reducing methane (CH4) emission, gastrointestinal nematode parasitism, and ruminal proteolysis. Within terpenoids, saponins and essential oils also mitigate CH4 emission, but triterpenoid saponins have rich biochemical structures with many clinical benefits in humans. The anti-methanogenic property in ruminants is variable because of the simultaneous targeting of several physiological pathways. This may explain saponin-containing forages' relative safety for long-term use and describe associated molecular interactions on all ruminant metabolism phases. Alkaloids are N-containing compounds with vast pharmacological properties currently used to treat humans, but their phytochemical usage as feed additives in ruminants has yet to be exploited as they may act as ghost compounds alongside other phytochemicals of known importance. We discussed strategic recommendations for phytochemicals to support sustainable ruminant production, such as replacements for antibiotics and anthelmintics. Topics that merit further examination are discussed and include the role of fresh forages vis-à-vis processed feeds in confined ruminant operations. Applications and benefits of phytochemicals to humankind are yet to be fully understood or utilized. Scientific explorations have provided promising results, pending thorough vetting before primetime use, such that academic and commercial interests in the technology are fully adopted.

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Section: Terpenes Biosynthesis and Functionalitymentioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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“…Not much has been reported in the phytochemistry of B. rosea , except for triterpene saponins isolated from its seeds. In particular, billiosides B and C, inhibited glucose intestinal absorption in rats and the enzyme glucose-6-phosphatase [ 55 ]. However, triterpene saponins isolated from other species of Sapindaceae or other families, were reported for its inhibitory activity against gram-positive and gram-negative bacteria [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration

Garcia-Garcia¹,

Orozco²,

Betancur³

et al. 2023

Heliyon

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“…Such approaches have been successfully utilized over decades, until very recently. A survey on new plant saponins reported in 2020 includes the bufadienolide 191 from Helleborus thibetanus, 617 klaineanoside A (192) from the stem barks of Chytranthus klaineanus, 618 scabioside A (193) from Scabiosa sicula L., 619 trillfurostanoside A (194) from the rhizomes of Trillium tschonoskii 620 and saponin 195 from the roots of Glandularia x hybrida. 621 This journal is © The Royal Society of Chemistry 2022…”

Section: Saponinsmentioning

confidence: 99%

The isolation of water-soluble natural products – challenges, strategies and perspectives

et al. 2022

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Triterpenoid saponins from the stem barks of Chytranthus klaineanus Radlk. ex Engl

Cited by 6 publications

References 23 publications

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Fabrication of polycaprolactone/calcium phosphates hybrid scaffolds impregnated with plant extracts using 3D printing for potential bone regeneration

The isolation of water-soluble natural products – challenges, strategies and perspectives

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