Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm

Farheen, Rabia; Siddiqui, Bina Shaheen; Mahmood, Iffat; Simjee, Shabana Usman; Majeed, Saba

doi:10.1016/j.phytol.2015.07.001

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…F. indica is naturally rich in these metabolites especially fatty acids, aromatic amine groups, and alkaloids. 44 Secondary metabolites have been shown to affect the bio-reduction of silver salts to form AgNPs. For instance, Marslin et al stated that avonoids are the major contributors to the green synthesis of nanoparticles.…”

Section: Lc-ms/ms Prole Of Capping Agents On Agnpsmentioning

confidence: 99%

Variation in surface properties, metabolic capping, and antibacterial activity of biosynthesized silver nanoparticles: comparison of bio-fabrication potential in phytohormone-regulated cell cultures and naturally grown plants

Khan

Ali

2020

RSC Adv.

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Section: Lc-ms/ms Prole Of Capping Agents On Agnpsmentioning

confidence: 99%

Variation in surface properties, metabolic capping, and antibacterial activity of biosynthesized silver nanoparticles: comparison of bio-fabrication potential in phytohormone-regulated cell cultures and naturally grown plants

Khan

Ali

2020

RSC Adv.

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“…The species included in the genus Fagonia other than Fagonia indica are Fagonia cretica, Fagonia olivieri and Fagonia Arabica 3 . Fagonia indica is restricted to warm and arid zones of the world and can be found mostly in arid and semi-arid areas of Pakistan, India and other Asian areas globally 4 .…”

Section: Introductionmentioning

confidence: 99%

UV-C mediated accumulation of pharmacologically significant phytochemicals under light regimes in in vitro culture of Fagonia indica (L.)

Abbasi

Khan

Khurshid

et al. 2021

Sci Rep

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Fagonia indica (L.) is an important medicinal plant with multitude of therapeutic potentials. Such application has been attributed to the presence of various pharmacological important phytochemicals. However, the inadequate biosynthesis of such metabolites in intact plants has hampered scalable production. Thus, herein, we have established an in vitro based elicitation strategy to enhance such metabolites in callus culture of F. indica. Cultures were exposed to various doses of UV radiation (UV-C) and grown in different photoperiod regimes and their impact was evaluated on biomass accumulation, biosynthesis of phytochemicals along antioxidant expression. Cultures grown under photoperiod (16L/8D h) after exposure to UV-C (5.4 kJ/m2) accumulated optimal biomass (438.3 g/L FW; 16.4 g/L DW), phenolics contents (TPC: 11.8 μgGAE/mg) and flavonoids contents (TFC: 4.05 μgQE/mg). Similarly, HPLC quantification revealed that total production (6.967 μg/mg DW) of phytochemicals wherein kaempferol (1.377 μg/mg DW), apigenin (1.057 μg/mg DW), myricetin (1.022 μg/mg DW) and isorhamnetin (1.022 μg/mg DW) were recorded highly accumulated compounds in cultures at UV-C (5.4 kJ/m2) dose than other UV-C radiations and light regimes.. The antioxidants activities examined as DPPH (92.8%), FRAP (182.3 µM TEAC) and ABTS (489.1 µM TEAC) were also recorded highly expressed by cultures under photoperiod after treatment with UV-C dose 5.4 kJ/m2. Moreover, same cultures also expressed maximum % inhibition towards phospholipase A2 (sPLA2: 35.8%), lipoxygenase (15-LOX: 43.3%) and cyclooxygenases (COX-1: 55.3% and COX-2: 39.9%) with 1.0-, 1.3-, 1.3- and 2.8-fold increased levels as compared with control, respectively. Hence, findings suggest that light and UV can synergistically improve the metabolism of F. indica and could be used to produce such valuable metabolites on commercial scale.

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“…variety indica is an important medicinal plant distributed in the most parts of Indo-Pakistan sub-continent and westwards to East and North tropical Africa. 17 This is used traditionally in treating fever, urinary discharges, asthma, thirst, dysentery, vomiting, liver trouble, skin diseases, typhoid, stomach troubles and toothache. 18 It is therapeutically used as a diabetes management.…”

Section: Introductionmentioning

confidence: 99%

FTIR, HPLC, GC-MS Analysis and Investigation of Hypoglycemic Effects of Leaves Extracts of Fagonia indica

Atiq-ur-Rehman¹,

Talib²,

Aftab³

2021

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Introduction: The present study was aimed for phytochemical analysis, investigations of different functional groups, the hypoglycemic potential of Fagonia indica leaves extracts, Reverse phase high performance liquid chromatography (RP-HPLC) and gas chromatography-mass spectroscopy (GC-MS) analysis of the most active hypoglycemic methanol extract. Methods: After extraction using cold maceration method, phytochemical screening, Fourier Transform Infrared (FTIR) spectroscopy, investigation of in vitro hypoglycemic potential of leaves extracts of the plant by α-glucosidase (sucrase) inhibitory assay were assessed using the standard methods. RP-HPLC and GC-MS analysis of the most active methanol extract was done to identify various biologically active compounds. Results: Phytochemical analysis showed various phytochemicals in the plant. FTIR spectral analysis showed diagnostic peaks of various functional groups. Methanol extract of the plant leaves showed the highest sucrase inhibition (37.0±1.4%) at 100 μg/mL concentration. It was followed by aqueous extract (29.1±1%), chloroform extract (27.7±0.5%) and n-hexane extract (25.5±0.9%) at the same concentration. RP-HPLC and GC-MS analysis of methanol extract showed the presence of various compounds with specific retention times. Conclusion:The plant leaves possessed in vitro hypoglycemic potential with competitive inhibition of enzyme sucrase. Methanol extract is the most effective agent in managing diabetes due to the presence of bioactive phytocomponents.

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Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm

Cited by 21 publications

References 17 publications

Variation in surface properties, metabolic capping, and antibacterial activity of biosynthesized silver nanoparticles: comparison of bio-fabrication potential in phytohormone-regulated cell cultures and naturally grown plants

Variation in surface properties, metabolic capping, and antibacterial activity of biosynthesized silver nanoparticles: comparison of bio-fabrication potential in phytohormone-regulated cell cultures and naturally grown plants

UV-C mediated accumulation of pharmacologically significant phytochemicals under light regimes in in vitro culture of Fagonia indica (L.)

FTIR, HPLC, GC-MS Analysis and Investigation of Hypoglycemic Effects of Leaves Extracts of Fagonia indica

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