Triterpenoids from the African tree Phyllanthus polyanthus

Ndlebe, Vuyelwa Jacqueline.; Crouch, Neil R.; Mulholland, Dulcie A.

doi:10.1016/j.phytol.2007.12.002

Cited by 25 publications

(15 citation statements)

References 12 publications

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“…The EI mass spectra [M] + m/z 468, with base peak at m/z 218, showed the fragmentation character for ursine-type compounds. Based on the above data, the compound is confirmed as α-amyrin acetate (Ndlebe et al 2008;Rastogi et al 1980;Feleke1 et al 2005).…”

Section: Test Materialsmentioning

confidence: 78%

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Adult mortality and blood feeding behavioral effects of α-amyrin acetate, a novel bioactive compound on in vivo exposed females of Anopheles stephensi Liston (Diptera: Culicidae)

Chenniappan

Murugan

2011

Parasitol Res

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The effect of α-amyrin acetate on mortality and blood feeding behavior in females of Anopheles stephensi was assessed by in vivo exposure on treated guinea pig skin. In vivo exposure to α-amyrin acetate caused mosquito knock down in the form of rapidly and normally reversible paralysis and the subsequent record at the end of a 24 h, revealed mortality rates of females increased from 0.0% (Control) to 76.9% at 1.6% α-amyrin acetate, the highest concentration which implies the contact toxicity of the α-amyrin acetate received through the sensitive parts of test species. The mean probing time responses significantly increased (P < 0.05) from 5.3 s (Control) to 22.9 s at 1.6% α-amyrin acetate. The blood feeding rates and the mean engorgement times were significantly shorter when compared to the control. The mean blood feeding rates of exposed females decreased from 91.7% (control) to 41.5% at 0.8% α-amyrin acetate concentrations, the mean engorgement time also decreased from 278.6 s (Control) to 158.7 s at 0.8% α-amyrin acetate concentrations. Mean blood feeding rates and mean engorgement time were statistically significant (P < 0.05) from that of control. The mean fecundity levels significantly reduced from 96.2 (Control) to 65.95%. The shortened mean engorgement time and smaller blood meal size have played a more important role in decline of fecundity. In vivo exposure to α-amyrin acetate caused increased mean probing time, decreased blood engorgement time and feeding rate and declined fecundity which reduce the overall survival and reproductive capacity of the malaria vector A. stephensi.

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Section: Test Materialsmentioning

confidence: 78%

“…int): 218 (100), 202 (32), 188 (31). 1 H NMR and 13 C NMR data are presented in Table 1 (Ndlebe et al 2008;Rastogi et al 1980;Feleke1 et al 2005).…”

Section: Test Materialsmentioning

confidence: 99%

Adult mortality and blood feeding behavioral effects of α-amyrin acetate, a novel bioactive compound on in vivo exposed females of Anopheles stephensi Liston (Diptera: Culicidae)

Chenniappan

Murugan

2011

Parasitol Res

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“…193 A similar species of this plant P. delpyanus decocotions of the roots are used by the Digo of Kenya in the treatment of sexually transmitted diseases. 195 Compounds 109-110 has not been isolated previously from a natural source but have been synthesised. 195 Compounds 109-110 has not been isolated previously from a natural source but have been synthesised.…”

Section: Pentacyclic Triterpenoidsmentioning

confidence: 99%

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

et al. 2015

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As a whole, the African continent is highly endowed with a huge floral biodiversity. Natural products which have been isolated from plants growing in this region have shown interesting chemical structures with diverse biological activities, which could serve as a starting point for drug discovery. In this study, a literature survey led to the collection of 864 secondary metabolites from 101 plant species from 57 plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants has been attempted. This review is a survey of the bioactivities of alkaloids and terpenoids which have been isolated from Southern African flora versus the ethnobotanical uses of the plants used in Southern African traditional medicine.

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“…: Picris hieracioides (Shiojima et al, 1989a) and Centaurea aspera (Picher et al, 1985); -amyrin acetate occurs in three Asteraceae spp. : Vernonia cinerea (Misra et al, 1984), Inula britannica and Echinops echinatus (Jakupovic et al, 2011) and in the Phyllanthaceae sp., Phyllanthus polyanthus (Ndlebe et al, 2008).…”

Section: Distribution Of Triterpenyl Acetates In Plantsmentioning

confidence: 99%

Occurrence of triterpenyl acetates in soil and their potential as chemotaxonomical markers of Asteraceae

Lavrieux

Jacob

Milbeau

et al. 2011

Organic Geochemistry

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As a part of a wider study aimed at determining new molecular biomarkers in soils and sediments that could be specific of distinct vegetation types with respect to unravelling past changes in land use, we analysed the neutral lipid content of soil developed in the catchment of a small lake in central France. The ketone/acetate lipid fraction of soil under pasture or meadow contains a series of pentacyclic triterpenyl acetates of wide structural diversity, most being reported in soil for the first time. The restricted number of potential plant sources of triterpenyl acetates (some produced by a single species) underlines the potential of triterpenyl acetates as new biomarkers to track past vegetation change in palaeoenvironmental studies, when found in natural archives such as soil, sediments or peat.

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Triterpenoids from the African tree Phyllanthus polyanthus

Cited by 25 publications

References 12 publications

Adult mortality and blood feeding behavioral effects of α-amyrin acetate, a novel bioactive compound on in vivo exposed females of Anopheles stephensi Liston (Diptera: Culicidae)

Adult mortality and blood feeding behavioral effects of α-amyrin acetate, a novel bioactive compound on in vivo exposed females of Anopheles stephensi Liston (Diptera: Culicidae)

The chemistry and bioactivity of Southern African flora I: a bioactivity versus ethnobotanical survey of alkaloid and terpenoid classes

Occurrence of triterpenyl acetates in soil and their potential as chemotaxonomical markers of Asteraceae

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