Tritiated thymidine autoradiographic study on origin and renewal of gastrin cells in antral area of hamsters

Fujimoto, Sotaro; Hattori, Takanori; Kimoto, Kunihiko; Yamashita, Satoshi; Fujita, Setsuya; Kawai, Keiichi

doi:10.1016/0016-5085(80)90429-1

Cited by 47 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The origin and renewal of G cells were investigated in hamster (58) and mouse antrum (89). A few G cells at the isthmus of the glands are capable of self-replication as shown by 0.3% (hamster) and 0.25% (mice) labeling after a single radioactive injection.…”

Section: Kinetics Of Endocrine Cellsmentioning

confidence: 99%

Endocrine Cells of the Gut

Polak

1989

Comprehensive Physiology

View full text Add to dashboard Cite

THE GASTROINTESTINAL TRACT possesses functions in addition to digestion; this concept, based on morphological evidence, stems, like the discovery of the first hormone secretin (8), from the beginning of the century. Masson (92) in 1914 attributed an endocrine function to the previously described chromafin (69), osmiophilic, basigranular yellow, or acidophil cells of the gastrointestinal mucosa.Reinforcement for this endocrine concept of gastrointestinal function was given as early as 1938 when Feyrter (53) described the existence of a group of "specialised, clear cells" diffusely dispersed throughout the body. Feyrter's clear cells were stained lightly by conventional histological methods (Fig. 1) and reacted to silver salts (showing argyrophilic and argentafinity properties). Feyrter (54) FIG. 6. Electron micrograph of somatostatin-containing cell from human gut. Cell is pear-shaped and extends from basement membrane to gut lumen where it terminates with microvilli (M). Large (250-300 nm), spherical, electron-dense secretory granules ( G ) are concentrated in basal half of cell. Glutaraldehyde-osmium fixation, Araldite embedding. Bar, 1 pm.

show abstract

Section: Kinetics Of Endocrine Cellsmentioning

confidence: 99%

Endocrine Cells of the Gut

Polak

1989

Comprehensive Physiology

View full text Add to dashboard Cite

show abstract

“…Since [ 3 H]‐thymidine autoradiography was first applied to the study of cell kinetics, the surface epithelial cells of the gastrointestinal mucosa have been examined extensively. In the gastric mucosa, most epithelial cells are produced in the isthmus region and migrate upwards or downwards along the tubules, differentiating into functionally mature cells 1–10 …”

Section: Introductionmentioning

confidence: 99%

Cell kinetics of slow renewing cell populations in mice stomach

Magami

Azuma

Inokuchi

et al. 2002

J of Gastro and Hepatol

Self Cite

View full text Add to dashboard Cite

The time required for the newly formed parietal and chief cells to reach the lower end of the gland was more than 300 days. As a total cell population, the renewal rate of parietal cells was more rapid than that of chief cells. However, in terms of the downward migrating cell population, the renewal rate of parietal cells was a little slower than that of chief cells. Smooth muscle cells showed almost no renewal.

show abstract

“…The gut endocrine cells have replicating capacities in mammals (Fujimoto et al 1980;Lehy 1982;Kubben and Bosman 1989). In the gut of sea bass larvae, only one endocrine cell type is found in mitosis: type II cells, which are considered as immature cells.…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of the endocrine cells of the intestine and rectum of sea bass (Dicentrarchus labrax L.): an ultrastructural study

1994

View full text Add to dashboard Cite

Several endocrine cell types were ultrastructurally characterized during the differentiation of the intestine and rectum of sea bass (Dicentrarchus labrax L.) larvae. Only one cell type (type I) was found in the posterior region of the undifferentiated gut of 5-day-old larvae (phase I). Types V and VI were found in both the intestine and rectum, types II, III and IV in the intestine, and types VII and VIII in the rectum of 9- and 12-day-old larvae (phase II), the rectum alone showing signs of functional differentiation. In phase III larvae, in which both the intestine and rectum were differentiated, types IX, X, XI, XII, XIII, XIV and XV were found in the intestine, only types X, XI and XII being seen in the rectum. Besides these, a new cell type, XVI, was observed in the intestine of 55- and 60-day-old larvae (phase IV), in which the digestive tract was completely differentiated. The endocrine cells appearing in phases I and II showed very scarce secretory granules and the ultrastructural features of undifferentiated cells. Some endocrine cell types in the earliest developmental stages were related to some of those found later. A maturational process of the endocrine cell types paralleled the differentiation of the intestine and rectum, with an apparent increase in the number of secretory granules accompanying organelle development.

show abstract

Tritiated thymidine autoradiographic study on origin and renewal of gastrin cells in antral area of hamsters

Cited by 47 publications

References 20 publications

Endocrine Cells of the Gut

Endocrine Cells of the Gut

Cell kinetics of slow renewing cell populations in mice stomach

Ontogeny of the endocrine cells of the intestine and rectum of sea bass (Dicentrarchus labrax L.): an ultrastructural study

Contact Info

Product

Resources

About