Tritiation of several antihypertensive agents at high specific activity

Radiochemistry

“…Catalytic dehalogenation continues to be a popular route to compounds tritiumlabelled at specific locations; recent examples being the preparation 75 of the AChE inhibitor [phenyl-7-3 H](À)-phenserine tartrate and hypersensitive agents such as telmisartan and lacidipine. 76 Conditions for optimising the synthesis 77 of the work-horse compound [ 11 C]methyl iodide, from [ 11 C]carbon dioxide, have been determined. [ 11 C]Methyl iodide has been used to label N-methyl-laudanosine 78 (en route to tetrahydroquinolinium derivatives), a range of cyclofenil derivatives 79 (breast cancer estrogen receptors), thymidine analogs 80 (imaging DNA synthesis) and naphthalenesulfonamides 81 (imaging of human CCR8).…”