Tritium isotope effect in high-performance liquid chromatography of eicosanoids

Hoi, Un; Lo, Shi-Lung; Iles, Jason K.; Rosenberger, Thad A.; Tam, Peter; Y.S.Hong,; Ahern, David G.

doi:10.1016/0952-3278(94)90243-7

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Generally, the degree of isotopic fractionation increases with the number of isotopic atoms and can be very significant for highly labelled compounds; however, for singly labelled compounds, the effect is small and can generally be ignored. Nevertheless, it is always good practice to ensure that the whole rather than part of a chromatographic peak is selected when quantification is undertaken.…”

Section: Discussionmentioning

confidence: 99%

Tritium: a coming of age for drug discovery and development ADME studies

Lockley

McEwen

Cooke

2012

Labelled Comp Radiopharmac

121

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Owing to recent developments in tritium chemistry and analysis, high‐quality tritium‐labelled drugs can now be prepared simply, cheaply and in timescales commensurate with those needed for rapid drug discovery in adsorption, distribution, metabolism and excretion (ADME) projects. Such 3H‐labelled drugs are enabling high‐quality decision‐making at key points in the drug discovery process, thus ensuring more effective research projects, a key issue in commercial success. In addition, tritium‐labelled compounds continue to play a significant role in ADME studies later in the pharmaceutical development process. This is especially so for highly potent and hence low‐dose agents, for drugs with complex structures and for those compounds that undergo molecular fragmentation as a result of metabolism.

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Section: Discussionmentioning

confidence: 99%

Tritium: a coming of age for drug discovery and development ADME studies

Lockley

McEwen

Cooke

2012

Labelled Comp Radiopharmac

121

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Syntheses and Uses of Isotopically Labelled Compounds ContainingCC,COorCNGroups

Zieliński

Kańska

2009

Patai's Chemistry of Functional Groups

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Introduction Syntheses and Uses of Compounds Containing C  C , C  O or C  N Groups Labelled with Stable Isotopes Synthesis and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Tritium Syntheses and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Radioactive Carbon Syntheses and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Radioactive Halogen Synthesis and Uses of Compounds Containing C  C , C  O , or CN Groups Labelled with Radioactive Sulphur Isotope Effect Studies Acknowledgements

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