Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases

Franchi, G; Morasca, L.; Reyers-Degli-Innocenti, I.; Garattini, S.

doi:10.1016/0014-2964(71)90059-4

Cited by 35 publications

(9 citation statements)

References 22 publications

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“…In contrast, metastases from tumours implanted intratibially, intracerebrally or intramuscularly in the mouse were restricted by similar regimens of chemotherapy (Franchi et al, 1971) and daily injections of only 50 mg/kg inhibited the formation of pulmonary metastases from the Lewis lung carcinoma (Franchi and Garattini, 1971).…”

Section: Icrf 159mentioning

confidence: 99%

“…Its anti-metastatic effects are thought to be due to binding to tumour cell surfaces, altering their movement and potential for attachment, and thus facilitating host recognition and destruction of cells liberated from the initial tumour mass (Francbi et al, 1971;Franchi and Garattini, 1973;Morasca, 1973). The compound does not influence the growth of tumour cells already lodged in other organs (Franchi et al, 1971).…”

mentioning

confidence: 89%

“…Thus, WR 1339 treatment suppresses the formation of pulmonary metastases from intramuscuilar grafts of the Lewis lung carcinoma (Franchi et al, 1971;Garattini, 1971, 1973), lymph node metastases from intratibial transplants of Ehrlich carcinoma (Rosso et al, 1969;Franchi et al, 1971) and pulmonary nietastasis of intracerebral implants of sarcoma 180 or Ehrlich carcinoma in Swiss mice (Rosso et a., 1969;Franchi et al, 1971). Enhancement of metastases has, however, been reported with other animal tumours treated with Triton WR 1339.…”

mentioning

confidence: 99%

“…The biological effects of Triton WR 1339 are complex, involving enhancement of the reticuloendothelial system, with activation of macrophage lysosomes (Franchi and Garattini, 1973;Franchi et al, 1971). Its anti-metastatic effects are thought to be due to binding to tumour cell surfaces, altering their movement and potential for attachment, and thus facilitating host recognition and destruction of cells liberated from the initial tumour mass (Francbi et al, 1971;Franchi and Garattini, 1973;Morasca, 1973).…”

mentioning

confidence: 99%

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Influence of ICRF 159 and triton WR 1339 on metastases of a rat epithelioma

Pimm¹,

Baldwin²

1975

Br J Cancer

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Summary.-ICRF 159 and Triton WR 1339 have been examined for their ability to suppress subcutaneous growth and pulmonary metastases from a transplanted rat epithelioma. Neither compound influenced subcutaneous tumour development or reduced the propensity to metastasize when administered in regimens reported to suppress pulmonary, lymph node or intracerebral metastases in other experimental systems.

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Section: Icrf 159mentioning

confidence: 99%

mentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Influence of ICRF 159 and triton WR 1339 on metastases of a rat epithelioma

Pimm¹,

Baldwin²

1975

Br J Cancer

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“…tion of rat epithelioma Sp1 cells when they were implanted intratibially, intracerebrally, or intramuscularly into experimental animals [7], but this was not the case when the same cells were placed subcutaneously [17].…”

mentioning

confidence: 99%

Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

et al. 2004

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A cross-linked form of the detergent Triton X-100, called Triton WR-1339, has been shown to reduce the spread of tumor cells in laboratory animals. However, some of these effects were controversial, probably due to the use of different tumor cell lines and varying sites of injection. In order to better understand these processes, we have used Triton X-100 and performed a molecular analysis of its growth-inhibitory function. Using the T24 bladder carcinoma cell line, we have shown that treatment of cells with this detergent caused a potent antiproliferative effect resulting from the downregulation of the key cell cycle regulators, the cyclin-dependent kinases (CDKs). CDK activity was lost due to a twofold effect, the increased expression of the CDK inhibitors p21^Cip1 and p27^Kip1 in combination with the reduced expression of cyclin A, a regulatory CDK subunit that is essential for CDK function. Taken together, our results provide a molecular basis for the antiproliferative effects of the Triton detergent, namely its differential effects on various parts of the cell cycle machinery.

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Techniques for inhibiting tumor metastases

Hoover¹,

Ketcham²

1975

Cancer

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Of the four major biological mechanisms of cancer spread, hematogenous dissemination is perhaps the most significant, as it usually heralds a fatal outcome for the patient. Recent experimental approaches have shown ways of altering the metastatic process and even totally inhibiting it in some animal models. It appears that these models may be applicable to certain human cancers. To prevent hematogenous metastasis formation the process must be inhibited at any one of four levels: 1) growth of the primary; 2) invasion of vessel walls; 3) release of viable tumor cells; or 4) entrapment and growth in distant organs. Judicious handling of the primary can decrease metastasis by minimizing the shedding of tumor cells. New experimental agents prevent the release of tumor cells from the primary by normalizing the blood vessels of the tumor. Warfarin, heparin, and fibrinolytic agents inhibit the entrapment of circulating tumor cells, presumably by their effect on coagulative mechanisms. A better understanding of the benefits of combined approaches to cancer using chemotherapy, irradiation, and immunotherapy, alone and as adjuncts to surgery, offers new opportunity to study methods of controlling metastatic disease.

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Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases

Cited by 35 publications

References 22 publications

Influence of ICRF 159 and triton WR 1339 on metastases of a rat epithelioma

Influence of ICRF 159 and triton WR 1339 on metastases of a rat epithelioma

Inhibition of Tumor Cell Growth by Triton X-100 through Specific Effects on Cell-Cycle-Regulatory Components

Techniques for inhibiting tumor metastases

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