Tritrichomonas foetus: Experimental infection in pregnant BALB/c mice

Barbeito, Claudio Gustavo; Woudwyk, Mariana A.; Cacciato, Claudio Santiago; Soto, Pedro; Portiansky, Enrique Leo; Catena, María del Carmen; Echavarria, Hilda; Gimeno, Eduardo Juan; Monteavaro, Cristina Esther

doi:10.1016/j.exppara.2008.06.011

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…Furthermore, Agnew et al (2008) also characterised a pregnant mouse model to study the pathogenesis of the disease. Lesions found in uteri of nonpregnant (Monteavaro et al, 2008) and pregnant (Barbeito et al, 2008;Woudwyk et al, 2013) mice are very similar to those found in experimentally infected heifers (Cobo et al, 2004). Therefore, these findings further support the use of the murine model to study the present disease.…”

Section: Introductionsupporting

confidence: 76%

“…We have satisfactorily reproduced the disease using low-dose oestrogens to synchronise oestrus in nonpregnant BALB/c mice (Soto et al, 2005). Shortly later, we have reproduced bovine tritrichomonosis in pregnant BALB/c mice treated with a low dose of estrogens (Barbeito et al, 2008). Furthermore, Agnew et al (2008) also characterised a pregnant mouse model to study the pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 87%

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Apoptosis and cell proliferation in the mouse model of embryonic death induced by Tritrichomonas foetus infection

Woudwyk

Zanuzzi

Nishida

et al. 2015

Experimental Parasitology

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Section: Introductionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 87%

Apoptosis and cell proliferation in the mouse model of embryonic death induced by Tritrichomonas foetus infection

Woudwyk

Zanuzzi

Nishida

et al. 2015

Experimental Parasitology

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“…BALB/c mice are the most susceptible laboratory animal and the disease can be reproduced in this strain using low-dose oestrogen to synchronize oestrous (Soto et al, 2005). Genital tritrichomonosis has also been induced in pregnant BALB/c mice treated with a low dose of oestrogen (Agnew et al, 2008;Barbeito et al, 2008).…”

mentioning

confidence: 99%

Lectin Binding Pattern in the Uterus of Pregnant Mice Infected with Tritrichomonas foetus

Woudwyk

Gimeno

Soto

et al. 2013

Journal of Comparative Pathology

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“…In our study, we also observed fibroblasts and fibrin, between the trophoblastic and decidual cells. In experimental models of embryonic death followed by resorption, an inflammatory response was also observed as fibrin deposition (Barbeito et al, 2008; Sordelli et al, 2017). Regardless of whether the resorptions are experimental or physiological, as in L. maximus , the events in both situations are similar.…”

Section: Discussionmentioning

confidence: 99%

Prenatal development in Lagostomus maximus (Rodentia, Chinchillidae): A unique case among eutherian mammals of physiological embryonic death

Acuña

Barbeito

Portiansky

et al. 2021

Journal of Morphology

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Embryonic death followed by resorption is a conserved process in mammals. Among the polyovular species, Lagostomus maximus (plains viscacha) constitutes a model of early and physiological embryonic death, since out of a total of 10–12 implants, 8–10 are resorbed during early/intermediate gestation, surviving are only the most caudal implantations of each uterine horn. This regular reproductive event is unique to this species, but many characteristics of the implantations during the early gestation of L. maximus, when embryonic death processes begin are unknown. The aim of the present work was to analyze the implantation sites of this species using morphological, morphometric, histochemical, lectinhistochemical, and immunohistochemical techniques to infer the possible causes of this event. Macroscopically, the length and width of the implantation sites significantly increased in a craniocaudal direction. Histochemically, the implantation sites did not differ in the expression of glycoconjugates and glycosidic residues. Furthermore, no variations were observed in cell renewal, hormone receptor expression, and decidualization. Both the glandular and vascular areas of the implantation sites significantly increased in the craniocaudal axis. Some necrotic cells and an inflammatory response with a predominance of lymphocytes and fibrin were observed in the cranial and middle but not in the caudal implantation sites. We conclude that signs of embryonic death and resorption are already observed in the early gestation of L. maximus. Our results reaffirm the hypothesis that postulates the key potential role of uterine glands and blood vessels in the gestation of the species, with emphasis on embryonic death. This pattern of embryonic death in L. maximus makes this species an unconventional mammalian model, which adds to the peculiarities of polyovulation (200–800 oocytes/estrus) and hemochorial placentation.

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Tritrichomonas foetus: Experimental infection in pregnant BALB/c mice

Cited by 9 publications

References 20 publications

Apoptosis and cell proliferation in the mouse model of embryonic death induced by Tritrichomonas foetus infection

Apoptosis and cell proliferation in the mouse model of embryonic death induced by Tritrichomonas foetus infection

Lectin Binding Pattern in the Uterus of Pregnant Mice Infected with Tritrichomonas foetus

Prenatal development in Lagostomus maximus (Rodentia, Chinchillidae): A unique case among eutherian mammals of physiological embryonic death

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