Trizyklische Antidepressiva - Klinik und Therapie der Intoxikation

Rasenack, U; Gattenlöhner, W

doi:10.1055/s-0028-1104235

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When used in therapeutic doses electrocardiographic changes and cardiovascular effects may occur in predisposed patients suffering from cardiac disease (Moir et al 1972;Jefferson 1975;Brorson & Wennerblom 1978), whereas acute overdose with TCA may result in severe disturbances such as sinus tachycardia, conduction defects, supraventricular tachycardia, ST and T wave abnormalities, ventricular arrhytmias, profound bradycardia, hypotension and depression of myocardial contractility (Barnes et al. 1968;Anderson et al 1971;Burrows et al 1976;Rasenack & Gattenlohner 1976;Thorstrand 1976). The electrocardiographic and cardiovascular complications caused by the TCA's are often ascribed the combined effect of the many different pharmacological actions of these drugs such as inhibition of t h e neuronal uptake mechanism for noradrenaline, anticholinergic action, a-adrenolytic action a n d membrane effects (Barth & Muscholl 1974& 1976Elonen 1974; Elonen et al 1974).…”

mentioning

confidence: 99%

Electrocardiographic and Cardiovascular Changes in Cats and Dogs Caused by High Doses of Amitriptyline Given as Conventional Tablets or a Sustained Release Preparation

Boeck

Jørgensen

1980

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

Electrocardiographic and haemodynamic changes have been compared in anaesthetized cats and in conscious dogs after high doses of amitriptyline given as conventional tablets or as a sustained release form. Plasma or serum levels of amitriptyline and nortriptyline were determined. In anaesthetized cats tablets caused marked ECG changes in all 6 animals combined with pronounced acidosis in 3 of the animals. The sustained release form caused no electrocardiographic changes in 4 animals and moderate disturbances in 2 animals, without acidosis in any of the 6 cats. Almost identical haemodynamic changes were seen in both groups. The plasma levels did not indicate poorer absorption from one preparation than from the other. In conscious dogs tablets caused marked clinical signs including restlessness, sedation and convulsions (2 dogs). Pronounced electrocardiographic changes were seen in all 4 dogs. Bundle branch block developed in 3 dogs. The sustained release preparation caused slight to moderate sedation and no convulsions. Pronounced electrocardiographic changes without bundle branch block were seen in one dog. Moderate changes were seen in the remaining dogs. Acidosis was most pronounced after the tablets. The serum drug levels clearly show that the absorption is much slower after administration of the sustained release preparation than after tablet administration and that somewhat lower amounts of drug are absorbed from the sustained release preparation than from tablets. It is evident from the present studies, that administration of high doses of amitryptyline as a sustained release preparation causes less toxic manifestations than given as conventional tablets. Part of the explanation may be that less amitryptyline is absorbed from the sustained release preparation than from tablets because of the high dose (dogs), but the main reason is most likely that the absorption from the sustained release preparation is much slower than the absorption from tablets.

show abstract

mentioning

confidence: 99%

Electrocardiographic and Cardiovascular Changes in Cats and Dogs Caused by High Doses of Amitriptyline Given as Conventional Tablets or a Sustained Release Preparation

Boeck

Jørgensen

1980

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

show abstract

“…Firstly, it is known that TCA inhibit the reuptake of norepinephrine at adrenergic receptors (Harper & Hughes 1977), leading to an increased level of circulating catecholamines. Secondly, TCA intensify the norepinephrine responses (Rasenack & Gattenlohner 1976) with development of increased arterial blood pressure and cardiac contractility. Peripheral vasodilatation due to an alfa-receptor blocking effect is well documented (Callingham 1967).…”

mentioning

confidence: 99%

“…Peripheral vasodilatation due to an alfa-receptor blocking effect is well documented (Callingham 1967). Blockade of betareceptors leading to decreased myocardial contractility has been suggested by Rasenack & Gattenlohner (1976).…”

mentioning

confidence: 99%

Imipramine Cardiotoxicity: An Electrocardiographic and Haemodynamic Study in Rabbits

Müller

Schulze

1980

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

The purpose of the present study was to investigate the cardiotoxicity of the tricyclic antidepressant imipramine. The experiments were carried out in rabbits during continous intravenous infusion of imipramine, and electrocardiographic and haemodynamic changes were observed. The blood flows were measured using the radioactive microsphere method based upon the principles of Fick and Stewart Hamilton. It was found that the decrease in heart rate and the changes in heart rhythm were always preceded by a fall in arterial blood pressure and cardiac contractility, expressed by a fall in dp/dtmax. On the basis of the results it is concluded that a direct depressing action on the myocardium is of importance in the development of cardiac complications, although both a depressing influence on cardiac conduction, an anticholinergic effect, and an influence on adrenergic factors may also contribute. The possibility of positive correlations between the changes in plasma‐ imipramine concentration and the changes in the dp/dtmax and the QRS complex cannot be excluded.

show abstract

Internistische Intensivmedizin und Betreuung von Suizidversuchs-Patienten: Konzepte und Probleme

Wedler¹

1996

Suizidalität

View full text Add to dashboard Cite

Trizyklische Antidepressiva - Klinik und Therapie der Intoxikation

Cited by 5 publications

References 0 publications

Electrocardiographic and Cardiovascular Changes in Cats and Dogs Caused by High Doses of Amitriptyline Given as Conventional Tablets or a Sustained Release Preparation

Electrocardiographic and Cardiovascular Changes in Cats and Dogs Caused by High Doses of Amitriptyline Given as Conventional Tablets or a Sustained Release Preparation

Imipramine Cardiotoxicity: An Electrocardiographic and Haemodynamic Study in Rabbits

Internistische Intensivmedizin und Betreuung von Suizidversuchs-Patienten: Konzepte und Probleme

Contact Info

Product

Resources

About