TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury

Wang, Yujin; Liang, Jing; Xu, Boyu; Yang, Jin; Wu, Zhourui; Cheng, Liming

doi:10.1016/j.lfs.2023.122282

Cited by 20 publications

(1 citation statement)

References 201 publications

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“…proBDNF can bind to the p75 neurotrophin receptor, inducing neuronal apoptosis, LTP, and amyloid-like degeneration. On the other hand, mBDNF binds to TrkB, producing protective effects, LTP, regulating synaptic plasticity, promoting neuronal development, proliferation, and dendritic and axonal growth ( Sun et al, 2023 ; Wang et al, 2024 ). The ratio of proBDNF to mBDNF varies with different brain regions and developmental stages, and can also be altered by pathological factors.…”

Section: A New Perspective On Exercise Therapy For Chronic Low Back P...mentioning

confidence: 99%

Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain

Zou,

Hao

2024

Front. Mol. Neurosci.

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Chronic low back pain patients often experience recurrent episodes due to various peripheral and central factors, leading to physical and mental impairments, affecting their daily life and work, and increasing the healthcare burden. With the continuous advancement of neuropathological research, changes in brain structure and function in chronic low back pain patients have been revealed. Neuroplasticity is an important mechanism of self-regulation in the brain and plays a key role in neural injury repair. Targeting neuroplasticity and regulating the central nervous system to improve functional impairments has become a research focus in rehabilitation medicine. Recent studies have shown that exercise can have beneficial effects on the body, such as improving cognition, combating depression, and enhancing athletic performance. Exercise-induced neuroplasticity may be a potential mechanism through which exercise affects the brain. This article systematically introduces the theory of exercise-induced neuroplasticity, explores the central effects mechanism of exercise on patients with chronic low back pain, and further looks forward to new directions in targeted neuroplasticity-based rehabilitation treatment for chronic low back pain.

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Section: A New Perspective On Exercise Therapy For Chronic Low Back P...mentioning

confidence: 99%

Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain

Zou,

Hao

2024

Front. Mol. Neurosci.

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Magnetron Sputtering Dual‐Ion Sequential Release Coating on PET Artificial Ligament Promotes Vascular Nerve Regeneration and Graft‐Bone Integration

Wu,

Xia,

Huang

et al. 2024

Adv Funct Materials

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Anterior cruciate ligament (ACL) injuries in sports have become increasingly prevalent, leading to the widespread adoption of polyethylene terephthalate (PET) artificial ligaments for ACL reconstruction due to their superior mechanical properties. However, the bio‐inertness of PET presents a significant challenge to graft‐bone integration, necessitating the enhancement of PET surface bioactivity. This study employed magnetron sputtering and hydrogel coating techniques to introduce strontium calcium‐phosphorus, and magnesium ions onto the surface of PET ligaments, achieving the sequential release of Mg, and Sr ions. The scanning electron microscopy analysis confirmed the uniformity and stability of the modified PET ligament surface material. The synergistic effect of sequential release from Mg/Sr‐PET has effectively promoted osteogenesis, angiogenesis, and neuronal differentiation in vitro. Moreover, in the reconstructed ACL model using Sprague‐Dawley rats, the histological staining, micro‐computed tomography, and biomechanical test results indicated that the Mg/Sr‐PET group notably stimulated blood vessel and nerve formation, demonstrating remarkable bone regrowth promotion. In conclusion, the sequential release and synergistic effect of magnesium and strontium ions significantly enhanced graft‐bone integration and accelerated rapid healing, offering valuable insights for improving clinical ACL reconstruction outcomes.

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