TrkB-Mediated Protection against Circadian Sensitivity to Noise Trauma in the Murine Cochlea

Meltser, Inna; Cederroth, Christopher R.; Basinou, Vasiliki; Savelyev, Sergey A.; Lundkvist, Gabriella B.; Canlon, Barbara

doi:10.1016/j.cub.2014.01.047

Cited by 86 publications

(95 citation statements)

References 39 publications

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“…Such factors could include the exact animal placement in relation to the sound source, the time of day the animal was exposed (Meltser et al, 2014), the exact amount of anesthetic that is absorbed into the blood, as well as all stress-related factors listed above. Even among heterogeneous genotypes of guinea pig and inbred strain mice the variability of ABR threshold shifts after unanesthetized AOE can be dramatic (Wang et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Longenecker

Galazyuk

2016

Front. Behav. Neurosci.

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The etiology of tinnitus is known to be diverse in the human population. An appropriate animal model of tinnitus should incorporate this pathological diversity. Previous studies evaluating the effect of acoustic over exposure (AOE) have found that animals typically display increased spontaneous firing rates and bursting activity of auditory neurons, which often has been linked to behavioral evidence of tinnitus. However, only a subset of studies directly associated these neural correlates to individual animals. Furthermore, the vast majority of tinnitus studies were conducted on anesthetized animals. The goal of this study was to test for a possible relationship between tinnitus, hearing loss, hyperactivity and bursting activity in the auditory system of individual unanesthetized animals following AOE. Sixteen mice were unilaterally exposed to 116 dB SPL narrowband noise (centered at 12.5 kHz) for 1 h under ketamine/xylazine anesthesia. Gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) was used to assess behavioral evidence of tinnitus whereas hearing performance was evaluated by measurements of auditory brainstem response (ABR) thresholds and prepulse inhibition PPI audiometry. Following behavioral assessments, single neuron firing activity was recorded from the inferior colliculus (IC) of four awake animals and compared to recordings from four unexposed controls. We found that AOE increased spontaneous activity in all mice tested, independently of tinnitus behavior or severity of threshold shifts. Bursting activity did not increase in two animals identified as tinnitus positive (T+), but did so in a tinnitus negative (T−) animal with severe hearing loss (SHL). Hyperactivity does not appear to be a reliable biomarker of tinnitus. Our data suggest that multidisciplinary assessments on individual animals following AOE could offer a powerful experimental tool to investigate mechanisms of tinnitus.

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Section: Discussionmentioning

confidence: 99%

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Longenecker

Galazyuk

2016

Front. Behav. Neurosci.

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“…BDNF further regulates astroglial plasticity in the SCN in a circadian fashion, which plays a crucial role in synchronization processes of circadian rhythms (Girardet et al, 2013). In a recent study, we found that BDNF via its receptor TrkB, protects mice against the negative consequences of an acute acoustic stressor, acoustic noise trauma, and that mice were significantly more susceptible to noise stress in the night as compared to day (Meltser et al, 2014). Thus, the increased BDNF mRNA levels in the SCN and increased BDNF in plasma may represent neural adaptations that prevent stressinduced alterations in the SCN and, in turn, facilitate changes in adrenal ACTH sensitivity via a phase advanced PER2::LUC rhythm.…”

Section: Sdl Increases Bdnf In the Scn And Plasmamentioning

confidence: 98%

Repeated psychosocial stress at night, but not day, affects the central molecular clock

Bartlang¹,

Savelyev²,

Johansson³

et al. 2014

Chronobiology International

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We have recently demonstrated that the outcome of repeated social defeat (SD) on behavior, physiology and immunology is more negative when applied during the dark/active phase as compared with the light/inactive phase of male C57BL/6 mice. Here, we investigated the effects of the same stress paradigm, which combines a psychosocial and novelty stressor, on the circadian clock in transgenic PERIOD2::LUCIFERASE (PER2::LUC) and wildtype (WT) mice by subjecting them to repeated SD, either in the early light phase (social defeat light = SDL) or in the early dark phase (social defeat dark = SDD) across 19 days. The PER2::LUC rhythms and clock gene mRNA expression were analyzed in the suprachiasmatic nucleus (SCN) and the adrenal gland, and PER2 protein expression in the SCN was assessed. SDD mice showed increased PER2::LUC rhythm amplitude in the SCN, reduced Per2 and Cryptochrome1 mRNA expression in the adrenal gland, and increased PER2 protein expression in the posterior part of the SCN compared with single-housed control (SHC) and SDL mice. In contrast, PER2::LUC rhythms in the SCN of SDL mice were not affected. However, SDL mice exhibited a 2-hour phase advance of the PER2::LUC rhythm in the adrenal gland compared to SHC mice. Furthermore, plasma levels of brain-derived neurotrophic factor (BDNF) and BDNF mRNA in the SCN were elevated in SDL mice. Taken together, these results show that the SCN molecular rhythmicity is affected by repeated SDD, but not SDL, while the adrenal peripheral clock is influenced mainly by SDL. The observed increase in BDNF in the SDL group may act to protect against the negative consequences of repeated psychosocial stress.

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“…Ideally, even the time of exposure should be standardized in light of evidence that cochlear noise vulnerability appears subject to a diurnal cycle (Meltser et al 2014). In some studies, the goal may be unilateral NIPTS, so that an anesthetized animal may be positioned to only expose one ear (e.g., Longenecker and Galazyuk 2011;Turner et al 2012;Hickox and Liberman 2014).…”

Section: Unilateral Noise Exposure and Anesthesiamentioning

confidence: 99%

Application of Mouse Models to Research in Hearing and Balance

Ohlemiller

Jones

Johnson

2016

JARO

106

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Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.

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TrkB-Mediated Protection against Circadian Sensitivity to Noise Trauma in the Murine Cochlea

Cited by 86 publications

References 39 publications

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Repeated psychosocial stress at night, but not day, affects the central molecular clock

Application of Mouse Models to Research in Hearing and Balance

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