Trks: Signal transduction and intracellular pathways

Klesse, Laura J.; Parada, Luis F.

doi:10.1002/(sici)1097-0029(19990515/01)45:4/5<210::aid-jemt4>3.0.co;2-f

Cited by 137 publications

(44 citation statements)

References 69 publications

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“…The biological effects of NGF are mediated through the ligand-specific high-affinity tyrosine kinase receptor TrkA and the common low-affinity receptor p75NTR. TrkA activates a series of protein phosphorylation cascades that results in the trophic effects of NGF [19,33]. In contrast, p75NTR is known to enhance TrkA phosphorylation in a variety of cells by increasing the ability of TrkA to bind NGF [5].…”

Section: Introductionmentioning

confidence: 68%

Co-expression of NGF and Its High-affinity Receptor TakA in the Rat Carotid Body Chief Cells

Yamamoto

Iseki

2003

Acta Histochem. Cytochem

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The expression and localization of NGF and its high-affinity receptor, TrkA, in the rat carotid body was investigated by use of in situ hybridization and immunohistochemistry, respectively. The immunoreactivity for TrkA was detected in most of chief cells and sustentacular cells, as well as in some nerve axons and perineurial cells, but not in Schwann cells. In electron microscopy, the immunoreactivity was localized to the cytoplasm. The mRNA for NGF was localized to most of chief cells and possibly also to sustentacular cells. These results demonstrated that carotid body chief cells, having the neural crest origin, produce both NGF and TrkA, implying a paracrine-autocrine role of NGF in the carotid body.

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Section: Introductionmentioning

confidence: 68%

Co-expression of NGF and Its High-affinity Receptor TakA in the Rat Carotid Body Chief Cells

Yamamoto

Iseki

2003

Acta Histochem. Cytochem

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“…The MAPK (Erk1/2) signaling pathway plays a critical role in the regulation of cell growth [27]. The high levels of Bcl-2 protein, located in the outer mitochondrial wall, enhance the survival of cells when exposed to adverse stimuli by controlling mitochondrial permeability and cyt c release [28].…”

Section: Discussionmentioning

confidence: 99%

Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells

Pan

Xie

et al. 2005

FEBS Letters

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Valproic acid (VPA), an anticonvulsant and moodstabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.

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“…It seems likely that activation of TrkA receptors on basophils, by NGF also results in the phosphorylation of Shc by the intrinsic kinase activity of the TrkA receptor (6), which results in activation of the ERK pathway that is similar to what is observed with IL-3. NGF-mediated activation of the ras-ERK pathway has been reported in other cells (41)(42)(43). The strength of the initial signals is, on average, weaker for NGF and, like IL-5, the weaker activation results in a more transient response, both at the level of ERK phosphorylation and priming for C5a-induced LTC4 release.…”

Section: Discussionmentioning

confidence: 99%

Differences in Functional Consequences and Signal Transduction Induced by IL-3, IL-5, and Nerve Growth Factor in Human Basophils

Miura¹,

Saini²,

Gauvreau³

et al. 2001

The Journal of Immunology

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Previous studies have indicated a redundancy in the effects of the cytokines, IL-3, IL-5, and nerve growth factor (NGF) on acute priming of human basophils. In the current study, we have examined the effects of these three cytokines on 18-h priming for leukotriene C4 generation, their ability to induce FcεRIβ mRNA expression, or their ability to sustain basophil viability in culture. We also examine a variety of the signaling steps that accompany activation with these cytokines. In contrast with the ability of IL-3 to alter secretagogue-mediated cytosolic calcium responses following 18-h cultures, 18-h treatment with IL-5 or NGF did not affect C5a-induced leukotriene C4 generation or alter C5a-induced intracellular Ca2+ concentration elevations. IL-3 and IL-5, but not NGF, induced FcεRIβ mRNA expression and all three improved basophil viability in culture with a ranking of IL-3 > IL-5 ≥ NGF. All three cytokines acutely activated the extracellular signal-regulated kinase pathway and the signaling elements that preceded extracellular signal-regulated kinase and cytosolic phospholipase A2 phosphorylation, consistent with their redundant ability to acutely prime basophils. However, only IL-3 and IL-5 induced Janus kinase 2 and STAT5 phosphorylation. This pattern of signal element activation among the three cytokines most closely matched their ability to induce expression of FcεRIβ mRNA. Induction of the sustained calcium signaling that follows overnight priming with IL-3 appeared to be related to the strength of the early signals activated by these cytokines but the relevant pathway required was not identified. None of the signaling patterns matched the ability of the cytokines to promote basophil survival.

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Trks: Signal transduction and intracellular pathways

Cited by 137 publications

References 69 publications

Co-expression of NGF and Its High-affinity Receptor TakA in the Rat Carotid Body Chief Cells

Co-expression of NGF and Its High-affinity Receptor TakA in the Rat Carotid Body Chief Cells

Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells

Differences in Functional Consequences and Signal Transduction Induced by IL-3, IL-5, and Nerve Growth Factor in Human Basophils

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