tRNA-Derived Small RNAs: Novel Insights into the Pathogenesis and Treatment of Cardiovascular Diseases

Wang, Shuxin; Luo, Zhengyang; Yuan, Ludong; Lin, Xin; Tang, Yuting; Yin, Leijing; Liang, Pengfei; Jiang, Bimei

doi:10.1007/s12265-022-10322-0

Cited by 15 publications

(5 citation statements)

References 60 publications

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“…LncRNAs play significant roles in cardiovascular disorders by influencing vascular function, cardiac development, and fibrosis [96][97][98][99][100]. An increasing body of evidence suggests that lncRNAs serve as crucial epigenetic modifiers in pulmonary hypertension.…”

Section: Lncrnas and Pahmentioning

confidence: 99%

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Non-coding RNAs function as diagnostic biomarkers and therapeutic targets in pulmonary arterial hypertension

Wang,

Zhu,

2024

Unravelling Molecular Docking - From Theory to Practice [Working Title]

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Pulmonary arterial hypertension is a disease characterized by complex pathogenesis and high mortality rates following diagnosis. Non-coding RNA plays a pivotal role in the development of pulmonary arterial hypertension, offering promising prospects as a diagnostic and therapeutic target for this condition. The utilization of nucleic acid drugs in disease treatment suggests the feasibility of packaging non-coding RNA into carrier systems and employing them in human pulmonary arterial hypertension (PAH) treatment through appropriate delivery routes. However, currently, no nucleic acid drugs are available for the clinical treatment of PAH. Identifying active regions within non-coding RNA through molecular docking analysis and developing suitable nucleic acid drugs hold great potential for advancing the field of PAH therapeutics.

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Section: Lncrnas and Pahmentioning

confidence: 99%

“…An increasing number of studies are investigating the association of tsRNAs with cardiovascular diseases, such as pulmonary hypertension [32,97,99]. Altered expression of tsRNAs in the blood and lung tissue of PAH patients has been found.…”

Section: Tsrnas and Pahmentioning

confidence: 99%

Non-coding RNAs function as diagnostic biomarkers and therapeutic targets in pulmonary arterial hypertension

Wang,

Zhu,

2024

Unravelling Molecular Docking - From Theory to Practice [Working Title]

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“…The origin of tRNA-derived fragments (tRFs) can be traced back to tRNA. When tRNA is not sufficiently modified, tRNA stability could be disrupted and cleaved to tRFs or degraded by Dicer, endonuclease Z (RNase Z/ELAC2) and other RNA endonucleases (RNases) [ 15 – 17 ]. tRFs/tiRNAs are categorized into five types based on their cleavage sites on mature tRNA by different nucleases, including 5’-half, 3’-half, 5’-tRF, 3’-tRF, and i-tRF [ 18 – 20 ].…”

Section: Trna Biological Functionmentioning

confidence: 99%

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

Yuan,

Zhang,

Lyu

et al. 2024

Cell Death Discov.

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AbstracttRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.

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“…Similarly, SNORD113‐6/AF357425 is involved in guiding 2'‐O‐Me of tRNAs, and a detailed analysis of tRNA Leu (TAA) revealed that this modification protects the tRNA from site‐specific cleavage and inhibits the formation of tRF Leu 47–64 , an 18‐nt long tRNA‐derived fragment (tRF). Functional analysis for tRF Leu 47–64 has not been performed, limiting the possibility of correlating the expression of this fragment with vascular remodeling; however, tRFs have previously been linked to cardiovascular development and diseases (van Ingen, Engbers, et al, 2022; Wang et al, 2023).…”

Section: Role Of Dlk1‐dio3 C/d Box Snornas In Developmental Disordersmentioning

confidence: 99%

Imprinted small nucleolar RNAs: Missing link in development and disease?

Gawade,

Raczynska

2023

WIREs RNA

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The 14q32.2 (DLK1‐DIO3) and 15q11‐q13 (SNURF‐SNRPN) imprinted gene loci harbor the largest known small nucleolar RNA clusters expressed from the respective maternal and paternal alleles. Recent studies have demonstrated significant roles for the 15q11‐q13 located SNORD115‐SNORD116 C/D box snoRNAs in Prader‐Willi syndrome (PWS), a neurodevelopmental disorder. Even though the effect of SNORD116 deletion is apparent in the PWS phenotype, similar effects of a SNORD113‐SNORD114 cluster deletion from the 14q32.2 locus in Kagami‐Ogata syndrome (KOS14) and upregulation in Temple syndrome (TS14) remain to be explored. Moreover, apart from their probable involvement in neurodevelopmental disorders, snoRNAs from the SNORD113‐SNORD114 cluster have been implicated in multiple biological processes, including pluripotency, development, cancers, and RNA modifications. Here we summarize the current understanding of the system to explore the possibility of a link between developmental disorders and C/D box snoRNA expression from the imprinted 14q32.2 locus.This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development RNA Processing > Processing of Small RNAs

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tRNA-Derived Small RNAs: Novel Insights into the Pathogenesis and Treatment of Cardiovascular Diseases

Cited by 15 publications

References 60 publications

Non-coding RNAs function as diagnostic biomarkers and therapeutic targets in pulmonary arterial hypertension

Non-coding RNAs function as diagnostic biomarkers and therapeutic targets in pulmonary arterial hypertension

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

Imprinted small nucleolar RNAs: Missing link in development and disease?

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