This document is about how to reduce set-up time using Single-Minute Exchange of Die (SMED) on an actual production process of interconnection axles, starting with a production and indicators analysis, followed by time studies, and then the rolling-out of all the SMED stages. The first activity carried out was observation, second assessment, and followed by implementation leading to standardization and the generation of standard manufacturing documents. At this point, training was carried out thereby enabling the validation and assessment of the versatility matrix. Finally, the productivity of the manufacturing cell was evaluated by looking at the new Overall Equipment Effectiveness (OEE) indicator to demonstrate the effectiveness of SMED in reducing start-up times and the fine-tuning of machinery.