Trojan‐Horse‐Like Stimuli‐Responsive Microcapsules

Mou, Chuan‐Lin; Wang, Wei; Li, Zhi-Lu; Ju, Xin; Xie, Rui; Deng, Nan‐Nan; Wei, Jie; Liu, Zhuang; Chu, Liang‐Yin

doi:10.1002/advs.201700960

Cited by 89 publications

(79 citation statements)

References 62 publications

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“…A porous shell endows microcapsules with a size-selective permeability [26]. Multicompartment microcapsules with multi-cores or capsule-in-capsule structures are designed for co-encapsulation and diverse programmable sequential release [27][28][29][30][31]. Smart microcapsules, which have magnetic materials embedded on the shell or in the cores, have been used for direction-specific delivery and release [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Guo

Hou

et al. 2020

Micromachines

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Microcapsules are attractive core-shell configurations for studies of controlled release, biomolecular sensing, artificial microbial environments, and spherical film buckling. However, the production of microcapsules with ultra-thin shells remains a challenge. Here we develop a simple and practical osmolarity-controlled swelling method for the mass production of monodisperse microcapsules with ultra-thin shells via water-in-oil-in-water (W/O/W) double-emulsion drops templating. The size and shell thickness of the double-emulsion drops are precisely tuned by changing the osmotic pressure between the inner cores and the suspending medium, indicating the practicability and effectiveness of this swelling method in tuning the shell thickness of double-emulsion drops and the resultant microcapsules. This method enables the production of microcapsules even with an ultra-thin shell less than hundreds of nanometers, which overcomes the difficulty in producing ultra-thin-shell microcapsules using the classic microfluidic emulsion technologies. In addition, the ultra-thin-shell microcapsules can maintain their intact spherical shape for up to 1 year without rupturing in our long-term observation. We believe that the osmolarity-controlled swelling method will be useful in generating ultra-thin-shell polydimethylsiloxane (PDMS) microcapsules for long-term encapsulation, and for thin film folding, buckling and rupturing investigation.

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Section: Introductionmentioning

confidence: 99%

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Guo

Hou

et al. 2020

Micromachines

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“…However, this technique is limited to generating a small number of layers due to the requirement of a large variety of solutes to achieve multilayers. Owing to the difficulty in the mechanical handling of fluid for the aforementioned applications in aqueous multiphase systems, such as in the form of monodisperse emulsion drops, alternative methods to manipulate fluid structure with all‐aqueous nature and high precision are required . In contrast, organic‐solvent‐based, high‐order multiphase emulsion drops have recently been fabricated by phase separation of ternary solutions using microfluidic devices .…”

mentioning

confidence: 99%

Generation of High‐Order All‐Aqueous Emulsion Drops by Osmosis‐Driven Phase Separation

Chao

Mak

Rahman

et al. 2018

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Droplets containing ternary mixtures can spontaneously phase-separate into high-order structures upon a change in composition, which provides an alternative strategy to form multiphase droplets. However, existing strategies always involve nonaqueous solvents that limit the potential applications of the resulting multiple droplets, such as encapsulation of biomolecules. Here, a robust approach to achieve high-order emulsion drops with an all-aqueous nature from two aqueous phases by osmosis-induced phase separation on a microfluidic platform is presented. This technique is enabled by the existence of an interface of the two aqueous phases and phase separation caused by an osmolality difference between the two phases. The complexity of emulsion drops induced by phase separation could be controlled by varying the initial concentration of solutes and is systematically illustrated in a state diagram. In particular, this technique is utilized to successfully achieve high-order all-aqueous droplets in a different aqueous two-phase system. The proposed method is simple since it only requires two initial aqueous solutions for generating multilayered, organic-solvent-free all-aqueous emulsion drops, and thus these multiphase emulsion drops can be further tailored to serve as highly biocompatible material templates.

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Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

“…This mutative technique could be of great interest to biochemists and contribute to numerous of applications requiring multistep reactions. Furthermore, as shown in Figure C, Chu and co‐workers described a coflowing microfluidic device‐based method to fabricate the Trojan‐horse‐like smart microcapsules . The microcapsules were synthesized in capsule‐in‐capsule structures through the quadruple emulsion process.…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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Trojan‐Horse‐Like Stimuli‐Responsive Microcapsules

Cited by 89 publications

References 62 publications

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Generation of Ultra-Thin-Shell Microcapsules Using Osmolarity-Controlled Swelling Method

Generation of High‐Order All‐Aqueous Emulsion Drops by Osmosis‐Driven Phase Separation

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

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