Trojan Nanobacteria System for Photothermal Programmable Destruction of Deep Tumor Tissues

Abstract

A novel bacteria-based drug delivery system, termed "Trojan nanobacteria system", has been developed in which nanoagents are internalized into engineered bacteria through bacteria-specific maltodextrin (MD) transporters. Compared to the method of attaching nanoagents to bacterial surfaces, this Trojan system features higher payloads and better stability. In cancer therapy, Trojan nanobacteria can specifically discriminate the tumor region and then penetrate deep tumor tissues. Once in the tumor, the Trojan nanobacteria systems are able to destroy deep tumor tissues due to the combined effects of antitumor protein expression (e.g., tumor necrosis factor-α, TNF-α) and photothermal properties.

Recent Updates on Functionalized Silicon Quantum-Dot-Based Nanoagents for Biomedical Applications

“…In 2022, Chu et al constructed a bacteriabased drug delivery system with high payload and stability. 117 In this system, the nanoagents, developed from Si NPs with the functionalization of maltodextrin and the load of ICG, can enter engineered bacteria. Taking advantage of the photothermal effect of ICG and the antitumor protein expression, this system is capable of disrupting deep tumor tissues (Figure 10b).…”

“…This work provides a novel idea for constructing a light-controlled drug delivery system. In 2022, Chu et al constructed a bacteria-based drug delivery system with high payload and stability . In this system, the nanoagents, developed from Si NPs with the functionalization of maltodextrin and the load of ICG, can enter engineered bacteria.…”

“…(b) Bacteria-based drug delivery system for the destruction of deep tumor tissues. Reproduced with permission from ref . Copyright 2022 Wiley-VCH.…”

Magnetotactic Bacteria AMB-1 with Active Deep Tumor Penetrability for NIR-II Photothermal Tumor Therapy

“…Recently, several bacteria such as Escherichia coli and Salmonella typhimurium have been developed as versatile carriers for delivering photothermal agents. − However, these strategies typically involve the covalent coupling of bacteria and photothermal agents or in situ synthesis of photothermal agents on bacterial surfaces, which are complex and tedious. Magnetotactic bacteria are a type of facultative anaerobe, which contain a specialized organelle called magnetosome .…”