2002
DOI: 10.1073/pnas.182233999
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Trojan particles: Large porous carriers of nanoparticles for drug delivery

Abstract: We have combined the drug release and delivery potential of nanoparticle (NP) systems with the ease of flow, processing, and aerosolization potential of large porous particle (LPP) systems by spray drying solutions of polymeric and nonpolymeric NPs into extremely thin-walled macroscale structures. These hybrid LPPs exhibit much better flow and aerosolization properties than the NPs; yet, unlike the LPPs, which dissolve in physiological conditions to produce molecular constituents, the hybrid LPPs dissolve to p… Show more

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Cited by 492 publications
(361 citation statements)
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“…Understanding the means by which fractures occur and the dynamics of their propagation in these systems may have very real benefits in, for example, stabilising foams, drops and bubbles by the addition of particles. One particularly interesting possibility lies in the delivery of drugs by inhalation, where trojan parcels of drugs in drops are coated with particulate rafts [6]. Our work suggests that the delivery process might be expedited by using the surfactant lining of the lungs to induce the rupture of the particle shell.…”
mentioning
confidence: 90%
See 1 more Smart Citation
“…Understanding the means by which fractures occur and the dynamics of their propagation in these systems may have very real benefits in, for example, stabilising foams, drops and bubbles by the addition of particles. One particularly interesting possibility lies in the delivery of drugs by inhalation, where trojan parcels of drugs in drops are coated with particulate rafts [6]. Our work suggests that the delivery process might be expedited by using the surfactant lining of the lungs to induce the rupture of the particle shell.…”
mentioning
confidence: 90%
“…Similarly, the addition of particles to the surface of liquid drops prior to coalescence stabilises the coalesced drops to the common pinch-off instability and can lead to reversible morphological instabilities such as buckling when subject to pressure [3]. Particle covered interfaces also occur at an intermediate stage during the production of colloidosomes [4], armored bubbles [5] and porous particle aerosols for drug delivery [6]. From both a fundamental and technological point of view these particulate interfaces pose a number of problems and opportunities.…”
mentioning
confidence: 99%
“…It is possible to confer the advantages of one class of vehicle on another by combining them. This approach has been used with microparticles in a gel , nanoparticles in a cross-linked hydrogel matrix (Yeo et al, 2006b), and nanoparticles in aerodynamically superior microparticles (Tsapis et al, 2002).…”
Section: Hybrid/composite Systemsmentioning
confidence: 99%
“…Much of the early work focused on axisymmetric geometries but more recently the simple problem of indentation has been used as a starting point in understanding some of the more complicated geometries that arise when an object with an intrinsic curvature is subject to different external loads [16,17]. By contrast, very little work has concerned the indentation of a pressurized elastic shell, despite its technological importance in applications such as pressure vessels [18] or capsules designed for drug delivery [19,20]. However, numerical simulations have been carried out for the case of a thick, fluid-filled shell with a constant volume [21] and for a thin shell (or membrane) subject to a constant internal pressure [20].…”
Section: Introductionmentioning
confidence: 99%