Tropane alkaloids

Reversal of Multidrug Resistance by Tropane Alkaloids from the Stems of Erythroxylum rotundifolium

“…The chemical shift and coupling constants for the proton signals in this unit were in agreement with a (Z)-3,4,5-trimethoxycinnamoyl group. 13 The 13 C NMR resonances were determined by an HMQC experiment to be δ 143.8 (C-), 119.2 (C-R), 107.8 (2C, C-2′, 6′), 60.9 (C-pOCH 3 ), and 56.1 (2C-mOCH 3 ). An HMBC experiment showed correlations from the olefinic protons (δ 6.88 and 5.96) and H-3 (δ 5.11) to the carbonyl at δ 165.2, thereby placing the cis-Tmc moiety at C-3.…”

“…The tropane alkaloids occur mainly in the plant families Convolvulaceae, Erythroxylaceae, Proteaceae, Rhizophoraceae, and Solanaceae and occasionally have been reported from plants in the Brassicaceae, Euphorbiaceae, and Olacaceae . Many biological and pharmacological reports on the tropane alkaloids have appeared, particularly concerning the neurochemical and physiological effects of cocaine. , The protective property of atropine against organophosphorus compounds is also well documented . In addition, the therapeutic uses of atropine sulfate as an antisialogogue adjuvant in surgery and as a gastrointestinal antispasmodic are well-known .…”

Recent Reviews

“…Acid derivatives, book, 202 Acridone alkaloids, 73 jV-Acylimidazoles, hydrolysis, 13 Alcohols, optically active, 87 Alkali metal supramolecular complexes, 104 Alkaloids, 65,70,71,73,76,85 synthesis, 65 1,3-Alkenynes, silicon-containing, 143 Alkoxyallenes, 167 Alienes, push-pull-substituted, 185 Allylic carbanions, stabilized, 115 Allylic substitution, enantioselective, 35 Amide hydrolysis, 13 Animation, of heterocycles, 22 Amino acids, book, 189 a-Amino-/3-hydroxy acids, 165 Amine N-oxides, in synthesis, 169 Amino sugars, synthesis, 165 Analysis, trace organic compounds, 130 Anion binding, 100 Anions, weakly coordinating, 41 Annelation, 91 to 1,2-diazines, 55…”

Synthesis and Functionalization of New Tropanes Designed for Use as Scaffolds in Combinatorial Chemistry

“…Consequently, tropanes have attracted our attention as potential candidates. Moreover, tropanetype alkaloids are biologically active [2,3] and, as far as we are aware, only two ''tropane-like'' scaffolds have hitherto been synthesized and used. [4,5] In view of the potential of this framework as a scaffold, we initiated a research program in this area.…”