Tropane alkaloids and toxicity of Convolvulus arvensis

A study to investigate the biological activity of proteoglycan mixture extract from Convolvulus arvensis

“…Previously, various effects of PGM including inhibiting tumor growth, suppressing ex vivo angiogenesis, enhancing ex vivo proliferation of lymphocytes and stimulating the phagocytosis was discovered. However, PGM was shown to have no notable impact on the growth of cancer cell lines in vitro [22,23].…”

“…Phytochemical experiments revealed that the plant is largely comprised of proteoglycan mixture called PGM which mainly consists of proteins and polysaccharides [20]. C. arvensis is classified as one of the 10 most poisonous weeds of the world; however, no clinical disease or gross lesions was observed in mice-fed low doses of C. arvensis [21][22][23]. Isolated lectins from C. arvensis were recognized as new and powerful inducers of gelatinase B, which is related with particular pathological conditions including shock syndrome [24].…”

Variations in antioxidant enzyme levels of rats exposed to ethanol extracts of Convolvulus species

“…Pseudotropine, a kind of Tropane alkaloids, may be the reason of observed hepatotoxicity after Convolvulus treatments. Todd et al (1995) showed that this component found in Convolvulus arvensis caused chronic horse poisoning as a result of low dose administration from the environment while graz- ing. It was also stated in this investigation that the clinical signs like depression, anorexia and deaths were observed in experimental mice after the high dose administration of C. arvensis.…”

Analysis of Quercetin and Kaempferol in an Alcoholic Extract ofConvolvulus pilosellifoliususing HPLC

“…Studies on the plants of this genus reported that they contain flavonoid, phenolic, tropane alkaloids, sterols, resin and sugars, and coumarins (Awaad et al 2011;Nacef et al 2010;Son et al 1991;. Plants of this genus possess different biological activities such as antibacterial, antiulcer, antimicrobial, antiasthmatic, anticancer, cytotoxic, and antioxidant activities (Nacef et al 2010;Zain et al 2012;Griffen and Lin 2000;Todd et al 1995;Calvino 2002). Convolvulus pilosellifolius Desr.…”