Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

Helgren, Maureen E.; Squinto, Stephen P.; Davis, Heather L.; Parry, David; Boulton, Teri G.; Heck, Carol; Zhu, Yuan; Yancopouloš, George D.; Lindsay, Ronald M.; DiStefano, Peter S.

doi:10.1016/0092-8674(94)90113-9

Cited by 207 publications

(155 citation statements)

References 64 publications

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“…14 The CNTF doses used in our EAE experiments are in same range as other studies in which CNTF or LIF were administered systemically. 26,41,75,76 However, we observed severe weight loss in mice treated with 1.2 mg/ kg/day CNTF, to the extent that some mice had to be sacrificed because of ethical reasons. CNTF is known for its capability to induce weight loss and is currently under investigation as a potential treatment in obesity.…”

Section: Discussionmentioning

confidence: 76%

Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis

Kuhlmann

Remington

Cognet

et al. 2006

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 76%

Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis

Kuhlmann

Remington

Cognet

et al. 2006

The American Journal of Pathology

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“…CNTF also enhanced the survival of sensory, hippocampal, and cerebellar neurons (26 -28) and increased survival of retinal photoreceptors in animal models of retinal degeneration (29 -31). On denervated rat skeletal muscles, CNTF reduced denervation-induced atrophy and increased muscular strength (32,33).…”

Section: Discussionmentioning

confidence: 99%

The Amino Acid Exchange R28E in Ciliary Neurotrophic Factor (CNTF) Abrogates Interleukin-6 Receptor-dependent but Retains CNTF Receptor-dependent Signaling via Glycoprotein 130 (gp130)/Leukemia Inhibitory Factor Receptor (LIFR)

Wagener

Aurich

Aparicio-Siegmund

et al. 2014

Journal of Biological Chemistry

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“…Neurotrophic factors have been shown to prevent atrophy of denervated skeletal muscle. [29][30][31] There is no similar direct evidence for the role of neurotrophic factors in denervated EOMs, but restoration and even increase in the cross-sectional area of fibers in reinnervatated EOMs may be an indirect evidence for the neurotrophic effect of reinnervation on EOMs. 24 This evidence might explain our finding of preservation of EOM volume in cases of acquired oculomotor palsy with aberrant regeneration.…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Magnetic Resonance Imaging of the Extraocular Muscles and Nerves Demonstrates Various Etiologies of Third Nerve Palsy

Kau

Tsai

Ortube

et al. 2007

American Journal of Ophthalmology

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Purpose-The etiology of third nerve palsy is usually diagnosed by history, motility examination, and presence of lid and pupil involvement, as well as cranial and vascular imaging. We used highresolution magnetic resonance imaging (hrMRI) of the oculomotor nerve and affected extraocular muscles (EOMs) to investigate oculomotor palsy.Design-Prospective, noncomparative, observational case series in an academic referral setting.Methods-Twelve patients with non-aneurysmal oculomotor palsy of duration 0.75 to 252 months were studied. In the orbit and along the intracranial oculomotor nerve, hrMRI at 1-2mm thickness was performed. Coronal plane images of each orbit were obtained in multiple, controlled gaze positions. Structural abnormalities of the oculomotor nerve and associated changes in EOM volume and contractility were evaluated.Results-Cases were categorized as tumor-related, congenital, diabetic, traumatic, and idiopathic according to clinical characteristics and hrMRI findings. Reduction of volume and contractility of affected EOMs were noted in six patients; however, there was no significant EOMs atrophy in two cases with diabetic oculomotor palsy, and four cases with aberrant regeneration. hrMRI demonstrated the oculomotor nerve at the midbrain and at EOMs in all cases, and in two case with previous normal neuroimaging elsewhere demonstrated contrast-enhancing tumors on the oculomotor nerve. One Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptAm J Ophthalmol. Author manuscript; available in PMC 2008 February 1. Conclusions-hrMRI provides valuable information in patients with oculomotor palsy, such as structural abnormalities of the orbit and oculomotor nerve, and atrophy and diminished contractility of innervated EOMs. This information could be helpful in diagnosis and management of oculomotor palsy.

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Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle

Cited by 207 publications

References 64 publications

Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis

Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis

The Amino Acid Exchange R28E in Ciliary Neurotrophic Factor (CNTF) Abrogates Interleukin-6 Receptor-dependent but Retains CNTF Receptor-dependent Signaling via Glycoprotein 130 (gp130)/Leukemia Inhibitory Factor Receptor (LIFR)

High-Resolution Magnetic Resonance Imaging of the Extraocular Muscles and Nerves Demonstrates Various Etiologies of Third Nerve Palsy

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