2024
DOI: 10.1093/pnasnexus/pgae207
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Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice

Fredrick J Rosario,
Kenneth Barentsen,
Theresa L Powell
et al.

Abstract: Placental System L amino acid transporter activity is decreased in pregnancies complicated by intrauterine growth restriction (IUGR) and increased in fetal overgrowth. However, it is unknown if changes in the expression/activity of placental Large Neutral Amino Acid Transporter Small Subunit 1 (Slc7a5/LAT1) are mechanistically linked to placental function and fetal growth. We hypothesized that trophoblast-specific Slc7a5 overexpression increases placental transport of essential amino acids, activates the place… Show more

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