Trophoblastic Disease: Analysis of 342 Patients

Nakano, Ryoko; Sasaki, Kenji; Yamoto, Mareo; Hata, Hirokazu

doi:10.1159/000299843

Cited by 29 publications

(4 citation statements)

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“…GTN is a malignant tumor that shows variable epidemiologic features and geographical patterns from published studies across the regions [3]. Data of choriocarcinoma from Asian countries were heterogeneous, ranging between 63 to 202 per 100,000 pregnancies in surveys from China, India, and Indonesia and below 23 per 100,000 pregnancies in studies from Japan and Singapore [3,[19][20][21][22][23]. In contrast with relatively high ratios of GTN found in these regions, a remarkably low ratio was found in Europe, North America, Australia, and some area of Latin America [3,19,20,24,25].…”

Section: Discussionmentioning

confidence: 99%

The 12-year Experience - A Retrospective and Hospital-based Study of Gestational Trophoblastic Neoplasia in the Northwest of China

Hao

et al. 2021

Preprint

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Purpose: To analyze clinical features of gestational trophoblastic neoplasia (GTN) patients who received initial treatments at the First Affiliated Hospital of Xi'an Jiaotong University.Methods: The patient record system was screened to extract clinical data including demographics, pregnancy history, diagnosis, staging, prognostic score, treatment. Student t test, x2 test, and Fischer’s exact test were used.Results: This study included 387 patients with GTN. Patients were divided into 2009-2014 and 2015-2020 groups, including 177 and 210 cases, respectively. Patients in 2015-2020 group had higher parity than those in 2009-2014 group (1.2±1.2 vs 0.9±1.2, P=0.030). Nullípara (73 [41.2%] vs 65 [31.0%]) and primípara (71 [40.1%] vs 84 [40.0%]) were more frequently seen in 2009-2014 group than those in 2015-2020 group, but multípara (61 [29.0%] vs 33 [18.7%]) was more common in 2015-2020 group (P=0.028). For patients in 2015-2020 group, more patients demonstrated 1 or more metastases (107 [51.0%] vs 63 [35.6%], P=0.014) than those in 2009-2014 group. Patients in 2015-2020 group had more distant invasions affecting more organs, including lungs (76 [36.2%] vs 52 [29.4%]) and lungs combining with other organs (31 [14.8%] vs 11 [6.2%]), than those in 2009-2014 group (P=0.003).Conclusions: Although patients diagnosed with GTN between 2015 to 2020 is associated with higher parity, more children, and more distant metastases, we cannot simply conclude that clinical features of GTN has changed over time.

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Section: Discussionmentioning

confidence: 99%

The 12-year Experience - A Retrospective and Hospital-based Study of Gestational Trophoblastic Neoplasia in the Northwest of China

Hao

et al. 2021

Preprint

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“…30 According to some studies, higher incidence of molar pregnancy is seen in maternal age below 20 years while others reported it to be over 35 years. [31][32][33] As 80% of hydatidiform moles are self-limiting and non-invasive, there are around 7-17% cases that show transformation into invasive mole and rarely into choriocarcinomas in 2-5% of cases. 34,35 The present study revealed cases of GTD ranged between 19 to 39 years with majority in age group of 26-30 years of age group.…”

Section: Discussionmentioning

confidence: 99%

The frequency of hydatidiform mole in a tertiary care hospital from central India

Patil¹,

Gangane²,

Shivkumar³

2020

IJPO

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The gestational trophoblastic disease (GTD) is a group of pregnancy related tumours encompassing complete and partial mole, invasive moles, choriocarcinomas and placental site trophoblastic tumours. Amongst all GTD, hydatidiform moles are the most common form. Hydatidiform mole is a relatively common gynecological condition which could presents like spontaneous abortion, one of the most common gynecological emergencies. Materials and Methods: Present study is a retrospective analysis to determine incidence of hydatidiform mole for eight years duration.All women who were diagnosed of molar pregnancy by estimation of beta hCG and histopathological examination during1st Jan 2010 to 31st Dec 2017 were enrolled in this study. During the study period, there were 84 cases of Molar pregnancy out of 33856 total deliveries. Results: The total number of deliveries reported in the study period was 33856 out of which 84 cases were of gestational trophoblastic disease (GTD). The prevalence of GTD in this tertiary care hospital was 2.48 per 1000 deliveries. During the study period, we had received 55 samples of products of conception and 3079 hysterectomy specimens. Out of 3134 cases, 84 cases were diagnosed as GTD. Out of these 84 cases 81cases were hydatidiform mole. There were two cases of choriocarcinomas and one case of placental site trophoblastic tumour. Conclusion: The prevalence of hydatidiform mole was higher among all entities of gestational trophoblastic disease. The serum beta hCG levels are very sensitive and specific for diagnosis. Histopathological examination is helpful for confirming diagnosis.

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“…However, some studies indicate an increase in the incidence of HM with decreasing maternal age below 20 years, while others report an increased risk in patients over 35 years. 23,24,25 .Berkowitz RS et al13 reported majority of patients diagnosed within 1st trimester often before classical clinical sign and symptoms develop. Late presentation resulted in uterus being larger than dates and appearance of theca lutein cysts in our patients 26 .…”

Section: Discussionmentioning

confidence: 99%