Tropical splenomegaly syndrome

Raval, Neelam; Shah, N J; Vani, S. N.

doi:10.1007/bf02820190

Cited by 9 publications

(3 citation statements)

References 3 publications

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“…Tropical splenomegaly syndrome (TSS) is another condition sometimes seen in the tropics, which presents with massive splenomegaly. However, PHT is uncommon in patients with TSS and the WHVP is within normal limits 50 . Moreover, elevated serum IgM levels and high malarial antibody titers are common in TSS patients.…”

Section: Differential Diagnosismentioning

confidence: 98%

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Non‐cirrhotic portal fibrosis: Current concepts and management

Sarin

Kapoor

2002

J of Gastro and Hepatol

150

183

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Non-cirrhotic portal hypertension (NCPH) comprises diseases having an increase in portal pressure (PP) due to intraheptic or prehepatic lesions, in the absence of cirrhosis. The lesions are generally vascular, either in the portal vein, its branches or in the perisinusoidal area. Because the wedged hepatic venous pressure is near normal, measurement of intravariceal or intrasplenic pressure is needed to assess PP. The majority of diseases included in the category of NCPH are well-characterized disease entities where portal hypertension (PHT) is a late manifestation and, hence, these are not discussed. Two diseases that present only with features of PHT and are common in developing countries are non-cirrhotic portal fibrosis (NCPF) and extrahepatic portal vein obstruction (EHPVO). Non-cirrhotic portal fibrosis is a syndrome of obscure etiology, characterized by 'obliterative portovenopathy' leading to PHT, massive splenomegaly and well-tolerated episodes of variceal bleeding in young adults from low socioeconomic backgrounds, having near normal hepatic functions. In some parts of the world, NCPF is called idiopathic portal hypertension (IPH) or 'hepatoportal sclerosis'. Because 85-95% of patients with NCPF and EHPVO present with variceal bleeding, treatment involves management with endoscopic sclerotherapy (EST) or variceal ligation (EVL). These therapies are effective in approximately 90-95% of patients. Gastric varices are another common cause of upper gastrointestinal bleeding in these patients and these can be managed with cyanoacrylate glue injection or surgery. Other indications for surgery include failure of EST/EVL, and symptomatic hypersplenism. The prognosis of patients with NCPF is good and 5 years survival in patients in whom variceal bleeding can be controlled has been reported to be approximately 95-100%.

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Section: Differential Diagnosismentioning

confidence: 98%

“…However, PHT is uncommon in patients with TSS and the WHVP is within normal limits. 50 Moreover, elevated serum IgM levels and high malarial antibody titers are common in TSS patients.…”

Section: Differential Diagnosismentioning

confidence: 99%

Non‐cirrhotic portal fibrosis: Current concepts and management

Sarin

Kapoor

2002

J of Gastro and Hepatol

150

183

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“…Tropical splenomegaly Syndrome (TSS) is also known as Hyperreactive Malarial Syndrome (HMS) is caused by repeated malarial infection in patients residing in zones endemic for malaria [7]. Most of these patients presents with abdominal pain due to massive splenomegaly.…”

Section: Discussionmentioning

confidence: 99%

Portal Vein Thrombosis with Tropical Splenomegaly-A Rare Coincidental Finding

Gupta¹,

Wadhawan²,

Gupta³

2018

J Liver

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Tropical splenomegaly syndrome has rarely been associated as a cause of portal hypertension in patients living in endemic malarial zone. TSS has however has never been reported to be associated with portal vein thrombosis. We report a case of a 17 year old male who presented with features of portal hypertension and on radiological evaluation was found to have portal vein thrombus with cavernoma formation. Liver biopsy was performed for ruling out other pathologies and cirrhosis and was found to have hemozoin pigment along with features of inflow vascular pathology. We here in report first case of tropical splenomegaly with portal vein thrombosis.

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Hyper-reactive malarial splenomegaly: Rare cause of pyrexia of unknown origin

Verma

Aggarwal

2007

Indian J Pediatr

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Hyper-reactive malarial splenomegaly (HMS) or Tropical splenomegaly syndrome(TSS), occurs in areas of high transmission of malaria. These children usually presents with gross splenomegaly and abdominal discomfort, while fever is not the usual manifestation in majority of them. It is a disease of young adults and rarely reported below 8 years of age. Here it is reported a three-year-old child who presented as pyrexia of unknown origin with hepatosplenomegaly, diagnosed as HMS.

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Tropical splenomegaly syndrome

Cited by 9 publications

References 3 publications

Non‐cirrhotic portal fibrosis: Current concepts and management

Non‐cirrhotic portal fibrosis: Current concepts and management

Portal Vein Thrombosis with Tropical Splenomegaly-A Rare Coincidental Finding

Hyper-reactive malarial splenomegaly: Rare cause of pyrexia of unknown origin

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