Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis

Hu, Xiaoxiang; Liu, Wenjing; Yan, Yi; Deng, Huaxiang; Cai, Yujie

doi:10.1016/j.ijbiomac.2023.127377

International Journal of Biological Macromolecules

2023

DOI: 10.1016/j.ijbiomac.2023.127377

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Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis

Xiaoxiang Hu,

Wenjing Liu,

Yi Yan

et al.

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2024

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“…Calystegines are a group of polyhydroxy alkaloids with a nortropane skeleton functionalized by three to five hydroxyl groups. This class of alkaloids is found in various plants, including those of the Solanaceae family [35]. Calystegines are known for their potential toxicity to humans, especially when consumed in large quantities.…”

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Health Benefits of the Alkaloids from Lobeira (Solanum lycocarpum St. Hill): A Comprehensive Review

Borsoi,

Pastore,

Arruda

2024

Plants

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Solanum is the largest genus within the Solanaceae family and has garnered considerable attention in chemical and biological investigations over the past 30 years. In this context, lobeira or “fruta-do-lobo” (Solanum lycocarpum St. Hill), a species predominantly found in the Brazilian Cerrado, stands out. Beyond the interesting nutritional composition of the fruits, various parts of the lobeira plant have been used in folk medicine as hypoglycemic, sedative, diuretic, antiepileptic, and antispasmodic agents. These health-beneficial effects have been correlated with various bioactive compounds found in the plant, particularly alkaloids. In this review, we summarize the alkaloid composition of the lobeira plant and its biological activities that have been reported in the scientific literature in the last decades. The compiled data showed that lobeira plants and fruits contain a wide range of alkaloids, with steroidal glycoalkaloid solamargine and solasonine being the major ones. These alkaloids, but not limited to them, contribute to different biological activities verified in alkaloid-rich extracts/fractions from the lobeira, including antioxidant, anti-inflammatory, anticancer, antigenotoxic, antidiabetic, antinociceptive, and antiparasitic effects. Despite the encouraging results, additional research, especially toxicological, pre-clinical, and clinical trials, is essential to validate these human health benefits and ensure consumers’ safety and well-being.

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confidence: 99%

Health Benefits of the Alkaloids from Lobeira (Solanum lycocarpum St. Hill): A Comprehensive Review

Borsoi,

Pastore,

Arruda

2024

Plants

View full text Add to dashboard Cite

show abstract

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Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis

Cited by 1 publication

References 112 publications

Health Benefits of the Alkaloids from Lobeira (Solanum lycocarpum St. Hill): A Comprehensive Review

Health Benefits of the Alkaloids from Lobeira (Solanum lycocarpum St. Hill): A Comprehensive Review

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