Tropism and Infectivity of Pandemic Influenza A H1N1/09 Virus in the Human Placenta

Xiao, Yanna; Yu, Feiyuan; Xu, Qian; Gu, Jiang

doi:10.3390/v14122807

Cited by 3 publications

(2 citation statements)

References 27 publications

(33 reference statements)

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“…The potential effects of the influenza virus on the mother and fetus are not well understood. Since influenza viruses are rarely passed through the placenta, the infection is more likely to cause preterm birth through other mechanisms, such as maternal fever and inflammatory responses (49)(50)(51). Elevated levels of pro-inflammatory cytokines in the body can cause immune perturbation, leading to the sluggish establishment of immune tolerance and excessive inflammation, which in turn affects placental function (52,53).…”

Section: Discussionmentioning

confidence: 99%

Risk of preterm birth in maternal influenza or SARS-CoV-2 infection: a systematic review and meta-analysis

Wang¹,

Ou²,

Wu³

et al. 2023

Transl Pediatr

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Background: Influenza is a major threat to global health and is an important cause of respiratory diseases.However, there was a controversy on the impacts of influenza infection on adverse pregnancy outcomes and the infant's health. This meta-analysis aimed to investigate the impact of maternal influenza infection on preterm birth.Methods: Five databases, including PubMed, Embase, Cochrane Library, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched for eligible studies on December 29, 2022. The Newcastle-Ottawa Scale (NOS) was used to assess the included quality of the included studies. As for the incidence of preterm birth, odds ratios (OR) and 95% confidence intervals (CIs) were pooled, and the results of the current meta-analysis were displayed in forest plots. Subgroup analyses based on similarity in different aspects were conducted for further analysis. A funnel plot was used to assess the publication bias. All of the above data analyses were performed using STATA SE 16.0 software.Results: A total of 24 studies involving 24,760,890 patients were included in this meta-analysis. Through the analysis, we found that maternal influenza infection significantly increased the risk of preterm birth (OR =1.52, 95% CI: 1.18 to 1.97, I 2 =97.35%, P=0.00). After subgroup analysis based on different types of influenzas, we found that women infected with influenza A and B (OR =2.05, 95% CI: 1.26 to 3.32, I 2 =96.14%, P<0.1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (OR =2.16, 95% CI:1.75 to 2.66, I 2 =0.00%, P<0.1) in pregnancy were at an increased risk of preterm birth, while those infected with influenza A alone or seasonal influenza were not (P>0.1).Conclusions: Women should take active steps to avoid influenza infection during pregnancy, especially influenza A and B and SARS-CoV-2, to reduce the possibility of preterm birth.

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Section: Discussionmentioning

confidence: 99%

Risk of preterm birth in maternal influenza or SARS-CoV-2 infection: a systematic review and meta-analysis

Wang¹,

Ou²,

Wu³

et al. 2023

Transl Pediatr

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“…Transplacental transmission of the 2009 AH1N1 virus was alleged in some cases, but definitive evidence was not available at the time. A recent study by Xiao et al concluded that the human placenta can be infected [ 6 , 7 ]. Nonetheless, data from the AH1N1 pandemic highlight that influenza during pregnancy escalates the likelihood of unfavorable pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Influenza Vaccination during Pregnancy: A Descriptive Study of the Knowledge, Beliefs, and Practices of Mexican Gynecologists and Family Physicians

Lopatynsky-Reyes,

Chacon-Cruz,

Greenberg

et al. 2023

Vaccines

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Background: Influenza in pregnancy is associated with elevated morbidity and mortality. Influenza vaccines are safe and effective in pregnancy. There are no Mexican surveys of physicians on knowledge, beliefs, and practices towards influenza and influenza immunization during pregnancy. Methods: A 32-question descriptive survey was conducted, addressing the general knowledge of influenza as well as beliefs and practices regarding influenza vaccination during pregnancy among Mexican physicians responsible for prenatal care, traditionally Obstetricians (OBGYNs) and Family Physicians (FPs). Results: A total of 206 surveys were available, 98 (47.6%) from OBGYNs and 108 (52.4%) from FPs, representing an estimated 2472 daily pregnancy consultations. In total, 54 of the 206 respondents (26.2%) were not aware that influenza is more severe during pregnancy, 106 of the 206 respondents (51.5%) ignored the potential side effects of influenza infection on the fetus, and 56.8% did not know when to vaccinate pregnant women. Pregnancy as a risk factor for developing influenza complications was only known by 99 of the 206 respondents (48.1%), and 6.1% believed that vaccination does not confer protection to the fetus. Conclusions: The current beliefs of Mexican OBGYNs and FPs for both influenza morbidity and mortality, and the importance of influenza vaccination during pregnancy are suboptimal. The drivers of these beliefs should be assessed to improve influenza vaccination recommendations, as knowledge alone is not sufficient.

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Impact of SARS-CoV-2 infection during pregnancy on the placenta and fetus

Li,

Schwartz,

et al. 2024

Seminars in Perinatology

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Tropism and Infectivity of Pandemic Influenza A H1N1/09 Virus in the Human Placenta

Cited by 3 publications

References 27 publications

Risk of preterm birth in maternal influenza or SARS-CoV-2 infection: a systematic review and meta-analysis

Risk of preterm birth in maternal influenza or SARS-CoV-2 infection: a systematic review and meta-analysis

Influenza Vaccination during Pregnancy: A Descriptive Study of the Knowledge, Beliefs, and Practices of Mexican Gynecologists and Family Physicians

Impact of SARS-CoV-2 infection during pregnancy on the placenta and fetus

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