Troponin I in hypothyroidism

Cohen, Lisa F.; Mohabeer, Ajay J.; Keffer, Joseph H.; Jialal, Ishwarlal

doi:10.1093/clinchem/42.9.1494

Cited by 26 publications

(12 citation statements)

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“…Troponin I is very specific be-cause it is found only in the heart muscle. Other publications also indicate that troponin I concentration is not falsely elevated in hypothyroidism, whereas the CK-MB concentration may be falsely elevated (4). Moreover, uremia and skeletal muscle trauma do not lead to an increase in troponin I concentration whereas the CK-MB fraction again may be falsely elevated (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Negative interference of bilirubin and hemoglobin in the MEIA troponin I assay but not in the MEIA CK&hyphen;MB assay

Dasgupta

Wells

Biddle

2001

Clinical Laboratory Analysis

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Troponin I is a sensitive and specific marker for the diagnosis of myocardial infarction. Several commercially available immunoassays measure the concentration of troponin I in serum. The microparticle enzyme immunoassay (MEIA) for troponin I (Abbott Laboratories, Abbott Park, IL) is widely used in clinical laboratories, including our hospital laboratory. We studied the effect of bilirubin and hemolysis on the MEIA for troponin I and compared our assay with a newly available chemiluminescent assay (CLIA) for troponin I (Bayer Diagnostics, Tarrytown, NY). We also measured CK-MB concentration using the MEIA CK-MB assay. One serum pool was prepared by combining several specimens of one patient with elevated troponin I and with a diagnosis of myocardial infarction. Other serum pools were prepared by combining sera with similar troponin I values. All serum pools showed normal bilirubin concentrations and had no hemolysis. Then we supplemented aliquots of serum pools with various concentrations of bilirubin (5.0, 10.0, 15.0, and 20.0 mg/dL). After supplementation, troponin I concentrations were measured again using the MEIA and CLIA. We observed a statistically significant decrease in troponin I concentration in the presence of bilirubin with the MEIA. For example, in serum pool 1, the troponin I concentration was 16.3 (bilirubin: 0.8 mg/dL). In the presence of 5.0, 10.0, 15.0 and 20.0 mg/dL of added bilirubin, the cardiac troponin I concentrations were 13.9, 13.4, 13.3 and 13.0 ng/ml respectively. We observed similar negative interference of bilirubin in troponin I measurement by the MEIA in other pools. The troponin I value decreased slightly (not statistically significant) in one pool and did not change in two other pools in the presence of bilirubin when we measured troponin I concentration using the CLIA. Interestingly, bilirubin did not interfere with the MEIA CK-MB assay. Moderate hemolysis did not have any effect on the troponin I assay using either the MEIA or CLIA. However, gross hemolysis (hemoglobin > 40 mg/dL) interfered with both assays for troponin I.

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Section: Introductionmentioning

confidence: 99%

Negative interference of bilirubin and hemoglobin in the MEIA troponin I assay but not in the MEIA CK&hyphen;MB assay

Dasgupta

Wells

Biddle

2001

Clinical Laboratory Analysis

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“…Although there is substantial literature on cTnI levels in various patient groups (14)(15)(16)(17), very few studies exist on the topic of cTnI levels in pregnancy. In the study of Narin et al (18), cTnI levels in the babies of preeclamptic mothers (n ¼ 15, 0.70 ng/ml) were reported to be higher than in a control group (n ¼ 17, 0.10 ng/ml) and it is also reported that this higher value can be associated with subtle cardiac damage in babies of preeclamptic mothers.…”

Section: Discussionmentioning

confidence: 99%

The effect of magnesium sulfate treatment on serum cardiac troponin I levels in preeclamptic women

Atalay

Erden

Turhan

et al. 2005

Acta Obstet Gynecol Scand

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Aim. To investigate serum cardiac troponin I levels before and after magnesium sulfate treatment in preeclamptic pregnant women. Materials and methods. Fifty-five pregnant women were included in the prospectively planned study. Study group patients (n ¼ 25) were pregnant women hospitalized with a preeclampsia diagnosis while the control group (n ¼ 30) were pregnant women with no medical or obstetric problem who had been attending the antenatal clinic. Serum cardiac troponin I levels were compared in the normal pregnant women and in preeclamptic pregnant women. These levels were also compared in the preeclamptic women before and after magnesium sulfate treatment. Mann-Whitney U-test was used for statistical analysis.Results. Groups were similar with respect to age, gravity, parity, and gestational age. The median serum cardiac troponin I levels in preeclamptic patients was 0.20 ng/ml (0.02-4.53) before treatment and 0.09 ng/ml (0.02-3.91) after treatment, while it was 0.02 ng/ml (0.0-0.05) in the control group. The serum cardiac troponin I level in the preeclamptic group was significantly high (P < 0.01), and pretreatment values in this group were significantly higher compared with post-treatment values (P < 0.01) Conclusion. Cardiac troponin I is a sensitive parameter for indicating minor myocardial damage which may occur in preeclampsia and for evaluating the efficiency of magnesium sulfate treatment.

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“…Guest et al concluded that troponin I is the best marker because it is found only in heart muscle. Other recent publications also indicate that troponin I concentration is not falsely elevated in hypothyroidism, where CK-MB fraction is elevated (8). Moreover, uremia and skeletal muscle trauma do not lead to an increase in troponin I concentrations where CK-MB fraction again can be falsely elevated (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 91%

Performance evaluation of a new chemiluminescent cardiac troponin I assay

Dasgupta

Chow

Nazareno

et al. 2000

J. Clin. Lab. Anal.

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Cardiac troponin I is a marker for diagnosis of myocardial damage. Several immunoassays are currently available for determination of concentrations of troponin I in serum. We evaluated a chemiluminescent assay for troponin I using ACS:180 automated analyzer (Bayer Diagnostics). We compared our results with two other immunoassays using the OPUS Magnum (OPUS troponin I assay, Dade Behring) and AxSYM (microparticle enzyme immunoassay, Abbott) analyzers. The within‐run and between‐run CVs were less than 5% for all three levels of controls. The chemiluminescent assay for troponin I was linear up to a serum troponin I concentration of 50 ng/mL and the detection limit was 0.1 ng/mL of troponin. A good correlation between troponin I concentration measured by the chemiluminescent assay (y axis) and the microparticle enzyme immunoassay (MEIA) (x axis) was observed, although the concentrations of troponin I in individual specimens were approximately four times higher, when measured by the MEIA assay, than those measured by chemiluminescent assay. The correlation coefficient was 0.98 with the regression equation y = 0.22x + 1.125. We also observed a good correlation in troponin I concentrations obtained by the chemiluminescent assay (y axis) and OPUS troponin I assay (x axis). The correlation coefficient was 0.96 and the regression equation was y = 0.79x – 0.52. The correlation coefficient was 0.93 when we compared troponin I concentrations obtained by the OPUS assay (x axis) with the corresponding concentrations obtained by the MEIA assay (y axis). The corresponding regression equation was y = 0.25x + 3.5. We conclude that the chemiluminescent troponin I assay showed good analytical performance. J. Clin. Lab. Anal. 14:224–229, 2000. © 2000 Wiley‐Liss, Inc.

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Troponin I in hypothyroidism

Cited by 26 publications

References 0 publications

Negative interference of bilirubin and hemoglobin in the MEIA troponin I assay but not in the MEIA CK&hyphen;MB assay

Negative interference of bilirubin and hemoglobin in the MEIA troponin I assay but not in the MEIA CK&hyphen;MB assay

The effect of magnesium sulfate treatment on serum cardiac troponin I levels in preeclamptic women

Performance evaluation of a new chemiluminescent cardiac troponin I assay

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