Troponin T as a marker of ischemic myocardial injury

Burlina, Angelo; Zaninotto, Martina; Secchiero, Sandra; Rubin, Daniela; Accorsi, Franco

doi:10.1016/0009-9120(94)90021-3

Cited by 79 publications

(38 citation statements)

References 21 publications

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“…cTnT remains the best marker of acute heart injury with high predictive values [13][14][15][16] . cTnT elevations peak between 8 and 12 h following a primary acute coronary insult and remain elevated for up to 7 days [14,16] .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Szymankiewicz

Matuszczak-Wleklak²,

Hodgman³

et al. 2005

Neonatology

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Background: Perinatal asphyxia constitutes a significant problem influencing neonatal mortality and morbidity. Objectives: The aim of the present work was to provide evidence of the usefulness of cardiac troponin T (cTnT) and echocardiographic investigations in the diagnosis of heart damage in full-term infants after intrauterine hypoxia. Material and Methods: The subjects were 39 asphyxiated and 44 term infants without fetal anoxia. Quantitative determinations of cTnT were performed between 12 and 24 h of life. Two-dimensional Doppler and color Doppler studies were performed at the bedside. We evaluated fractional shortening (FS), cardiac output (CO), cardiac index (CI), tricuspid (TI) and mitral (MI) insufficiency. Results: Asphyxiated infants presented increased cTnT (mean 0.141 ± 0.226 vs. 0.087 ± 0.111ng/ml; p < 0.01) and TI (38.5 vs. 11.4% of population; p < 0.05) compared to healthy infants. CO, CI and FS remained in the same range. Conclusions: We found cTnT to be the most useful among accessible diagnostic tools used in post-hypoxic heart damage in neonates. The data from our relatively small population study suggest a cTnT value of >0.1 ng/ml as a reliable marker of myocardial injury in neonates. Further study should be performed to generate a receiver-operator characteristic curve to discover what the cut-off level should be.

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Section: Discussionmentioning

confidence: 99%

Usefulness of Cardiac Troponin T and Echocardiography in the Diagnosis of Hypoxic Myocardial Injury of Full-Term Neonates

Szymankiewicz

Matuszczak-Wleklak²,

Hodgman³

et al. 2005

Neonatology

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“…TnT, a regulatory contractile protein compartmentalized into a minor cytosolic (5%) and a major myofibrillary (95%) bound fraction, is not normally found in blood and has been shown to be a sensitive and specific marker for myocardial cell damage in adult patients with unstable angina, acute cardiac infarction and postcardiomyotomy situations [8,10]. TnT release occurs within the first 24 h after limited myocardial injury, e.g., after myocardial infarction with early reperfusion, and remains elevated for several days [11].…”

Section: Discussionmentioning

confidence: 99%

“…The determination of TnT was performed by an enzyme immunoassay (ELISA troponin T; Boehringer Mannheim, Italia, Milan, Italy) based on a single-step sandwich principle, with streptavidin-coated tubes as the solid phase and two monoclonal anti-human cardiac TnT antibodies [10]. The assay was carried out using the microprocessor-controlled Boehringer Mannheim ES-300 photometer; the test results were obtained in 90 min.…”

Section: Methodsmentioning

confidence: 99%

Cardiac Troponin T in Newborn Infants with Transient Myocardial Ischemia

Trevisanuto¹,

Lachin

Zaninotto

et al. 1998

Neonatology

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Cardiac troponin T (TnT) is a regulatory contractile protein whose detection in the circulation has been shown to be a specific and sensitive marker for ischemic myocardial cell injury both in adult and pediatric populations. We measured serum cardiac TnT in 15 consecutive full-term neonates presenting with bradycardia and electrocardiographic features of transient myocardial ischemia. Their median TnT concentrations (0.5 µg/l, range 0.01–0.37) were statistically comparable to our laboratory reference values for healthy term newborns (median 0.17 µg/l, range 0.01–0.42) (p = NS), but significantly higher with respect to our reference limits for healthy adults (median 0.01 µg/l, range 0.01–0.1) (p < 0.05). Our data demonstrate high TnT levels in neonates during the first days of life with respect to adults and similar TnT concentrations in term infants with and without TMI.

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“…20 However, the preoperative levels of cTnT in neonates (younger than 1 month of age) was found to be significantly higher, although still in the normal range. The possible explanation is that neonatal patients undergoing surgery are in a more compromised cardiac situation from a cardiac viewpoint, with detectable myocardial damage even before surgery.…”

Section: Discussionmentioning

confidence: 81%