Troponin T Measurement Can Predict Persistent Left Ventricular Dysfunction in Peripartum Cardiomyopathy

Abstract

Passive-active immunoprophylaxis with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine provides a high level of protection against vertical transmission of hepatitis B virus (HBV). Nevertheless, 1 in 10 children of HBV carriers have chronic hepatitis B early in their lives despite immunoprophylaxis because they were infected in utero. This study of 469 pregnant women testing positive for hepatitis B surface antigen (HbsAg) was conducted to learn whether giving HBIG to HBV carriers in the third trimester can prevent vertical transmission of the virus. Of the women entered into the study, all of whom were asymptomatic, 126 (group 1) tested positive for hepatitis B e antigen (HbeAg), while 343 (group 2) did not. HBIG was given intramuscularly in a dose of 200 IU at 28, 32, and 36 weeks of pregnancy. All newborn infants received 100 IU of HBIG within 12 hours of birth as well as the first of 3 doses of hepatitis B vaccine (the subsequent doses were given at ages 1 and 6 months).In group 1, 16% of infants whose mothers received HBIG in the third trimester tested positive for HbsAg at birth and 7% at age 6 months. The respective figures for infants whose mothers were not treated were significantly higher at 39% and 23%. No such treatment-related difference was observed in group 2 infants. At age 6 months, rates of protective levels of anti-Hbs antibody were 32% in group 1 infants whose mothers were HbeAg-positive and 56% in group 2 infants when the mothers had not received HBIG while pregnant. The respective figures for infants whose mothers were treated in the third trimester were 76% and 89%. Neither mothers nor their infants experienced adverse effects related to the administration of HBIG or hepatitis B vaccine.The investigators conclude that, if all HbsAg-positive pregnant women, regardless of HbeAg status, were to receive HBIG in the last weeks of pregnancy, their infants would be better protected against chronic HBV infection. ABSTRACTFetal karyotyping of cells obtained by amniocentesis may take as long as 3 weeks, and many pregnant women experience anxiety during the interval. This randomized, controlled study evaluated 2 tactics for lessening anxiety: issuing karyotyping results on a prespecified date rather than when they become available and presenting early results Preconception and Prenatal Care 495 496 Obstetrical and Gynecological Survey ABSTRACTAbout 1 in 4 primary cesarean deliveries take place during the second stage of labor. Not only is second-stage surgery technically more difficult, but the fetus is at risk of hypoxia-related morbidity. This prospective observational study of primary cesarean deliveries was carried out at 13 university centers that make up the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Of 11,981 primary cesarean deliveries, 9265 were done in the first and 2716 in the second stage of labor. Women in the latter group were likely to be older, nulliparous, and white, and they had a smaller body mass index at the time of del...

Inflammatory Markers-Serum Level of C-Reactive Protein, Tumor Necrotic Factor-α, and Interleukin-6 as Predictors of Outcome for Peripartum Cardiomyopathy

“…Logistic regression analysis of NYHA FC, SBP, EDD, ESD, EF, CRP, IL6, and TNF-a revealed that only the baseline plasma levels of IL-6, TNF-a, and NYHA FC (OR = 2.67, CI 95 %, 1.04-6.83) were independent predictors of death (Table 5). Recovery of systolic function occurs in roughly half of affected women and usually occurs within 6 months of symptom onset [16]. A rapid recovery of EF is often seen in patients after initial diagnosis and dieresis [17].…”

A contemporary review of peripartum cardiomyopathy

“…Troponin levels appear to correlate inversely with LVEF, suggesting a possible role in guiding management. 42 …”

Measurement of Troponin in Cardiomyopathies

“…94 In a prospective multi-centre study of 106 patients with newly diagnosed PPCM surviving over 6 months 31% patients had elevated TnT levels which negatively correlated with left ventricular ejection fraction (LVEF) at follow-up. 95 Preeclamptic pregnant women have been reported to have elevated TnI levels. 96 Although preeclampsia is associated with a higher incidence of PPCM no causal association has been shown.…”