Troponine Ic et CK-MB après pontage coronarien avec ou sans CEC

Cauliez, Bruno; Redonnet, M; Darras, S.; Guignery, J; Marinier, S; Lavoinne, Alain

doi:10.1016/j.immbio.2003.12.004

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…While cardiac surgeries are generally associated with high morbidity and mortality, it is crucial to identify patients at risk of developing postoperative complications and initiate relevant therapeutic interventions, to prevent any adverse outcomes. Several biochemical markers like CK-MB, 27 brain natriuretic peptide (BNP), 28 myoglobin, 29 and ischemic modified albumin 30 demonstrate a notable rise following cardiac surgeries and are employed as a predictor of surgical outcomes. However, they either lack sensitivity and specificity or were elevated for a very short time, hence necessitating the need for better markers.…”

Section: Discussionmentioning

confidence: 99%

Postoperative cardiac troponin I as an indicator of surgical outcomes: A systematic review

Ahmed

Pervez

Rehan

et al. 2022

Journal of Cardiac Surgery

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Introduction Cardiac surgeries are generally associated with high morbidity and mortality. To prevent any adverse outcomes, it is crucial to identify patients at risk of developing postoperative complications and initiate relevant therapeutic interventions. Several biomarkers are used to determine postoperative myocardial injury but they either lack sensitivity and specificity or are elevated for a short time. In this systematic review, we evaluate postoperative troponin I as a predictor of postoperative myocardial infarction, mortality, and hospital and Intensive Care Unit stay. Methods This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis guidelines. A thorough literature search was conducted over PubMed, clinicaltrials. gov, and the Cochrane library from inception till May 24, 2022 using relevant keywords, and only articles that met the pre‐defined criteria were recruited. Results Following a comprehensive literature search, a total of 359 articles were obtained. Following a rigid screening and full‐length review, only 13 studies met our inclusion criteria and were included. The recruited studies evaluated data from a total of 12,483 individuals and assessed troponin I as a predictor of at least one outcome. Conclusion Troponin I has the potential to be used as a stand‐alone predictor of surgical outcomes following coronary artery bypass grafting and valvular surgeries. However, supplementing it with other markers and scores offers the best chance at timely diagnosing any complications.

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Section: Discussionmentioning

confidence: 99%

Postoperative cardiac troponin I as an indicator of surgical outcomes: A systematic review

Ahmed

Pervez

Rehan

et al. 2022

Journal of Cardiac Surgery

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“…In patients with a perioperative myocardial infarction, the maximum concentration is typically observed approximately 24 hours following the intervention. The diagnosis can be established with 100% sensitivity at 24 hours with threshold values of 32 µg/L for CK-MB (41). According to Steuer et al, CK-MB ≥50 μg/L with serum ASAT ≥ 2.55 μkat/L are strongly suggestive of perioperative myocardial injury 24 hours after cardiac surgery (42).…”

Section: Ck-mb and Troponin-t Release Pattern In Cardiac Injurymentioning

confidence: 99%

Surgical Ablation of Atrial Fibrillation with Cryo and Radiofrequency Concomitant to Mitral Valve Surgery : Clinical, Biochemical and Echocardiography Outcomes

Boano

2023

Linköping University Medical Dissertations

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Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice. In cardiac surgery, the negative influence of AF on shortand long-term outcomes has made concomitant ablation procedures more common. The indications, clinical aspects, results, risks, and benefits of the additional surgical ablation are still valuable topics for discussion. This compilation thesis consists of four papers aiming to investigate some of the clinical, biochemical, and echocardiographic aspects of surgical ablation for AF (Cox-Maze IV) when performed concomitant to mitral valve surgery (MVS).Through a retrospective, case-control, single-center study, we described the impact of the Cox-Maze IV procedure added to MVS with s focus on postoperative heart failure (paper I).Cryoenergy (cryo) and radiofrequency (RF) are the two different energy sources mainly used in Cox-Maze IV for AF ablation. To achieve linear scars in the atrial wall, the RF procedure uses heat damage, whereas the cryo method freezes down to -150°C. Through a prospective, randomized, longitudinal, controlled study, we compared the biochemical responses of the two ablative methods in concomitant MVS and the release of enzymes expressing myocardial injury, as well as inflammatory, cell stress, and apoptosis-specific proteins. We could show that cryo results in a larger release of markers for myocardial damage but has no impact on the early inflammatory response (paper II).Extended scar lesions resulting after maze may influence atrial function. As the left atrium plays a key role in the altered cardiac hemodynamics in AF, an echocardiographic analysis of the effects of the Cox-Maze IV procedure concomitant to MVS on the left atrium was carried out. The impacts of the two energy sources (cryo and RF) on left atrial remodeling and function had not been compared previously. Their direct effect on left atrial remodeling and mechanical function were assessed 1 year after surgery in pa-Abstract 2 tients with restored sinus rhythm. Sinus rhythm restoration after MVS concomitant to Cox-Maze IV results in a reduced left atrium size regardless of the energy source used. Three-dimensional echocardiography showed that, compared to RF, the extension of the ablation area produced by cryo implies major left atrium structural remodeling affecting systolic function. The negative effect on left atrium remodeling seems to be linear with the duration of the AF (paper III).An overview of the pacemaker implantation rate after the Cox-Maze IV procedure concomitant to MVS was obtained in a multicenter study using national qualitative registers (SWEDHEART, Carath, Svenska ICDoch Pacemakerregistret) (paper IV, sumbitted).Our results contribute to optimizing surgical indications and patient selection, providing a deeper understanding of the biochemical and echocardiographic changes during and after surgical ablation.Toste Länne, who introduced me to research. You were at my half-time seminar encouraging our projects and always being positive and supportive.My supervisor Farkas Vánky, ...

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Troponine Ic et CK-MB après pontage coronarien avec ou sans CEC

Cited by 2 publications

References 13 publications

Postoperative cardiac troponin I as an indicator of surgical outcomes: A systematic review

Postoperative cardiac troponin I as an indicator of surgical outcomes: A systematic review

Surgical Ablation of Atrial Fibrillation with Cryo and Radiofrequency Concomitant to Mitral Valve Surgery : Clinical, Biochemical and Echocardiography Outcomes

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