Trouble With a Shunt: Alcohol and Spastic Paraparesis

O'Brien, J. James; Staples, Christopher; Florin, Timothy H.

doi:10.1053/j.gastro.2009.10.059

Cited by 5 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the obvious relationship with the shunt, a common theory is that hepatic dysfunction and portosystemic shunt lead to toxic substances accumulate in the body, and toxic substances produce damage to the spinal cord after passing through the blood-brain barrier (BBB). [23] Interesting, the SCFA butyrate is able to restore BBB integrity. That is, bacterial species which can produce butyrate have an effect on the physiological state of the BBB via metabolic signals.…”

Section: Discussionmentioning

confidence: 99%

The effect of fecal microbiota transplantation on Hepatic myelopathy

Sun

Lan

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of fecal microbiota transplantation on Hepatic myelopathy

Sun

Lan

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

Motor Cortex Mapping in Patients With Hepatic Myelopathy After Transjugular Intrahepatic Portosystemic Shunt

Cui

Shuyao

et al. 2019

Academic Radiology

View full text Add to dashboard Cite

Brain white matter fiber tracts involved in post-transjugular intrahepatic portosystemic shunt hepatic myelopathy

Wang

Guo²,

Guo³

et al. 2017

NeuroReport

View full text Add to dashboard Cite

We aimed to detect alterations in diffusion characteristics of brain white matter in hepatic myelopathy (HM) patients. Liver cirrhosis patients with (n=25) and without (n=18) HM after transjugular intrahepatic portosystemic shunt and 26 healthy controls were enrolled in this study. All participants were scanned with diffusion tensor imaging on a 3T Siemens scanner. Tract-based spatial statistics analysis was used to detect abnormalities of intracranial white matter tracts. Correlations between clinical characteristics and diffusion metrics were also calculated. HM patients showed widespread decreased fractional anisotropy values in association fibers, callosal fibers, thalamic fibers, and limbic system fibers (P<0.01, family-wise error-corrected) compared with healthy controls. In addition, HM patients showed lower fractional anisotropy values in the corpus callosum, corona radiata, external capsule, and superior longitudinal fasciculus compared with cirrhosis patients without myelopathy (P<0.01, family-wise error-corrected). Furthermore, limb muscle strength grading was correlated with the diffusion characteristics of the corpus callosum and superior longitudinal fasciculus in HM patients (P<0.05). HM patients suffer from more distinct changes of white matter fiber tracts than cirrhosis patients without myelopathy. In addition, alterations of the corpus callosum and superior longitudinal fasciculus may be associated with the major motor disturbance in HM. Our finding may shed light on the underlying neuropathological mechanism of HM.

show abstract

Trouble With a Shunt: Alcohol and Spastic Paraparesis

Cited by 5 publications

References 2 publications

The effect of fecal microbiota transplantation on Hepatic myelopathy

The effect of fecal microbiota transplantation on Hepatic myelopathy

Motor Cortex Mapping in Patients With Hepatic Myelopathy After Transjugular Intrahepatic Portosystemic Shunt

Brain white matter fiber tracts involved in post-transjugular intrahepatic portosystemic shunt hepatic myelopathy

Contact Info

Product

Resources

About