Troubles de l’humeur et prophylaxie antipaludique (méfloquine) : à propos de deux cas

Nabih, F. Oueriagli; Touhami, M.; Laffinti, A.; Abilkacem, L.

doi:10.1016/j.encep.2011.01.013

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…As with earlier generations of quinoline anti-malarials, and consistent with product label warnings of encephalopathy, case reports of psychiatric effects from mefloquine typically describe a complex and diverse range of effects on mood, personality, thought, cognition, sleep, and behaviour [ 191 ]. These include asthenia [ 192 ], melancholia [ 193 ], anxiety [ 194 ], phobias [ 195 , 196 ], feelings of unrest [ 197 , 198 ], paranoia [ 199 ], increased self-esteem [ 200 , 201 ], impaired judgment [ 198 ], social disinhibition [ 192 , 202 ], giddiness [ 203 ], altered sexual libido [ 204 ], manic behaviour and paranoid delusions or psychosis [ 194 , 200 , 202 , 204 ], hyperreligiosity [ 204 ], depersonalization [ 192 , 198 , 205 ], concentration and cognitive problems [ 197 ], problems with word finding [ 201 ], disorientation [ 193 , 198 , 206 ], symptoms of amnesia and confusion or disorientation [ 192 , 193 , 203 ], sleep disorders [ 207 , 208 ], severe nightmares, [ 209 ] sleep paralysis and “flashbacks” [ 201 ], suicidal ideation [ 210 ], and suicide [ 176 , 211 – 213 ].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

Nevin

Croft

2016

Malar J

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The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders of personality, mood, memory, attention, thought, and behaviour. In this article, the history of psychiatric effects attributed to malaria and post-malaria syndromes is reviewed, and insights from the historical practice of malariotherapy in contributing to understanding of these effects are considered. This review concludes with a discussion of the potentially confounding role of the adverse effects of anti-malarial drugs, particularly of the quinoline class, in the unique attribution of certain psychiatric effects to malaria, and of the need for a critical reevaluation of the literature in light of emerging evidence of the chronic nature of these adverse drug effects.

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Section: Introductionmentioning

confidence: 99%

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

Nevin

Croft

2016

Malar J

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“…In the nigropedunculopontine pathway, SNr neurons extend direct connections to pontine cerebellar structures, the superior colliculus, and the pedunculopontine tegmental nucleus [ 112 ], where they play a role in modulation of saccadic and pursuit eye movements in response to sensory and attention signals from the cortex, as well as balance and coordination. A dysregulation of inhibitory input to visual or auditory centres could therefore account for auditory and visual hallucinations frequently reported in cases of mefloquine psychosis [ 37 , 114 – 117 ].…”

Section: K Atp Channels In Movementmentioning

confidence: 99%

Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine

Quinn

2015

Journal of Parasitology Research

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The alkaloid toxin quinine and its derivative compounds have been used for many centuries as effective medications for the prevention and treatment of malaria. More recently, synthetic derivatives, such as the quinoline derivative mefloquine (bis(trifluoromethyl)-(2-piperidyl)-4-quinolinemethanol), have been widely used to combat disease caused by chloroquine-resistant strains of the malaria parasite, Plasmodium falciparum. However, the parent compound quinine, as well as its more recent counterparts, suffers from an incidence of adverse neuropsychiatric side effects ranging from mild mood disturbances and anxiety to hallucinations, seizures, and psychosis. This review considers how the pharmacology, cellular neurobiology, and membrane channel kinetics of mefloquine could lead to the significant and sometimes life-threatening neurotoxicity associated with mefloquine exposure. A key role for mefloquine blockade of ATP-sensitive potassium channels and connexins in the substantia nigra is considered as a unifying hypothesis for the pathogenesis of severe neuropsychiatric events after mefloquine exposure in humans.

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The Mefloquine Intoxication Syndrome: A Significant Potential Confounder in the Diagnosis and Management of PTSD and Other Chronic Deployment-Related Neuropsychiatric Disorders

Nevin

Ritchie

2015

Posttraumatic Stress Disorder and Related Diseases in Combat Veterans

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Troubles de l’humeur et prophylaxie antipaludique (méfloquine) : à propos de deux cas

Cited by 7 publications

References 9 publications

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine

The Mefloquine Intoxication Syndrome: A Significant Potential Confounder in the Diagnosis and Management of PTSD and Other Chronic Deployment-Related Neuropsychiatric Disorders

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