Troubles neurocognitifs chez les personnes âgées avec maladie oncologique

Abstract

Troubles neurocognitifs chez les personnes âgées avec maladie oncologiqueLes chimiothérapies peuvent induire une dysfonction cognitive transitoire ou permanente, pouvant aller d'une plainte cognitive subjective à une atteinte réelle de la mémoire de travail, de l'attention ou du langage. L'interaction entre l'atteinte cognitive attribuée à ces thérapies et celle liée à l'âge est une question grandissante compte tenu du vieillissement de la population. Elle justifie une attention particulière à la détection précoce de troubles cognitifs afin d'en réduire l'impact négatif sur la qualité de vie et optimiser la prise en charge médicale. Dans cet article, nous abordons le concept de « chemobrain », et en revoyons les connaissances actuelles de physiopathologie, de neuro-imagerie ainsi que les phénotypes neuropsychologiques, afin de proposer quelques outils de détection et de prise en charge au cabinet. Cancer-related cognitive impairment in older adultsChemotherapy is associated with transient or permanent cognitive dysfunction ranging from subjective complaints to measurable deficits in working memory, attention and language. Given that old age may be related to cognitive decline, the interaction between chemotherapy-induced cognitive impairment and the effects of age is of growing concern in view of our aging population. Chemotherapy-associated cognitive dysfunction may have an additive impact on pre-existing age-related cognitive performance decline, which calls for awareness in its detection, to reduce impact on quality of life and improve management of older patients. We discuss here the « chemobrain », concept, review the existing evidence about pathophysiology, neuroimaging and cognitive phenotype and propose practical tools for routine detection in the outpatient setting.Vu l'hétérogénéité des études sur lesquelles les connaissances actuelles se basent, l'importance des facteurs confondants Dre LAÏLA BARATALI a,b , Dr KRISTOF MAJOR a,b , Dr OLIVIER ROUAUD b et Pr BOGDAN DRAGANSKI b,c,d

The high burden of symptoms associated with cognitive impairment in lung cancer patients: A latent class analysis

“…Those cytokines will deregulate neurotransmitters, increase oxidative stress, and decrease neurogenesis and neuroplasticity, which can lead to CRCI. 45 An implication of this is that the pain-fatigue-sleep disturbance-depression SC and CRCI may share common inflammatory mechanisms.…”

Prevalence and associated factors of chemotherapy‐related cognitive impairment in older breast cancer survivors

“…An increase in the number of elderly patients with cancer and/or cognitive impairment is inevitable in an ageing population, especially older BCS with higher survival rates (Gonda et al, 2019). Older BCS are increasing in number, many of them will experience CRCI that can seriously affect QOL (Baratali et al, 2020), which has not yet been adequately studied. This may be owing to underlying neural complexities and ageing interweaving as potential confounding factors (Denlinger et al, 2014).…”