Trousseau's syndrome due to asymptomatic pancreatic adenocarcinoma

Murinello, António; Guedes, Pedro; Rocha, G L; Serrano, Ana; Figueiredo, António; Damásio, Helena; Freire, João; Cunha, Fernando de Queiróz; Alves, Liliana

doi:10.1016/j.jpg.2012.09.006

Cited by 3 publications

(6 citation statements)

References 13 publications

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“…Treatment with heparin has been demonstrated effective in preventing thrombotic events, including stroke. 3,4 Trousseau syndrome (TS) is a hypercoagulable state, associ-ated with cancer, that includes various disorders probably involving multiple overlapping mechanisms. It has been suggested the term "Trousseau syndrome" be restricted to unexplained thrombotic events that either precede the diagnosis of an occult visceral malignancy or appear concomitantly with the tumor.…”

mentioning

confidence: 99%

Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)

Finelli

Nouh

2016

AJNR Am J Neuroradiol

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confidence: 99%

Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)

Finelli

Nouh

2016

AJNR Am J Neuroradiol

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“…The patient was a tobacco smoker, with a mild alcohol intake. There was no fever, sweating, weight loss, respiratory, digestive, urinary or other symptoms [4]. Laboratory tests revealed elevated levels of GGT, ALP, LDH, amylase and lipase, the tumor markers CA 19.9 and CEA were within normal range.…”

Section: Introductionmentioning

confidence: 90%

“…In 2013, Murinello, et al reported the case of a 58-year-old man with venous thrombosis in the upper and lower limbs and lung embolism related to unsuspected PAC and hepatic metastases [4]. The patient was a tobacco smoker, with a mild alcohol intake.…”

Section: Introductionmentioning

confidence: 99%

“…Imaging studies showed an infiltrative mass in the pancreatic uncinate process involving the superior mesenteric vessels, embolism in the upper and inferior lobes of the right lung; and nodules compatible with hepatic implants. Further aspiration biopsy of the liver and pancreas confirmed PAC with metastases, the patient evolved to death due to ischemic stroke, necropsy studies were not done [4]. The authors focused on the Trousseau's syndrome, a thrombotic diathesis associated with cancer of pancreas, stomach, colon and rectum, lung, breast, ovary or prostate, producing mucin [4].…”

Section: Introductionmentioning

confidence: 99%

“…Further aspiration biopsy of the liver and pancreas confirmed PAC with metastases, the patient evolved to death due to ischemic stroke, necropsy studies were not done [4]. The authors focused on the Trousseau's syndrome, a thrombotic diathesis associated with cancer of pancreas, stomach, colon and rectum, lung, breast, ovary or prostate, producing mucin [4].…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic Adenocarcinoma: Role of the Site-Specific of Metastases

Santos¹,

Santos²

2017

Int J Pathol Clin Res

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Pancreatic adenocarcinoma is a severe malignant condition with a median survival lower than one year, and a five-year survival rate of about 30%, including tumors resected at early stage. Recurrences within two years occur in up to 80% of the resected tumors. More than two thirds of advanced pancreatic adenocarcinomas have single site of metastases, mainly affecting the liver, lungs, bones and brain, by decreasing order of frequency. The studies herein commented suggest that patients with lung-only metastases or with isolated distant lymph node implants have better outcomes than those with liver-only metastases. The physiopathological mechanisms are not well known; moreover one should consider the role of Trousseau's syndrome on estimated survival time. This paraneoplastic syndrome is characterized by hypercoagulability causing arterial and venous thromboses. KeywordsMetastases, Pancreatic adenocarcinoma, Trousseau's syndrome terial and venous invasions are similar to those with exclusive liver metastases [1,2]. Among 13233 patients with advanced PCA, 66.3% had single site of metastases; and the main affected organs were: Liver, lungs, bones and brain, by decreasing order of frequency [3].In 2013, Murinello, et al. reported the case of a 58-year-old man with venous thrombosis in the upper and lower limbs and lung embolism related to unsuspected PAC and hepatic metastases [4]. The patient was a tobacco smoker, with a mild alcohol intake. There was no fever, sweating, weight loss, respiratory, digestive, urinary or other symptoms [4]. Laboratory tests revealed elevated levels of GGT, ALP, LDH, amylase and lipase, the tumor markers CA 19.9 and CEA were within normal range. Imaging studies showed an infiltrative mass in the pancreatic uncinate process involving the superior mesenteric vessels, embolism in the upper and inferior lobes of the right lung; and nodules compatible with hepatic implants. Further aspiration biopsy of the liver and pancreas confirmed PAC with metastases, the patient evolved to death due to ischemic stroke, necropsy studies were not done [4]. The authors focused on the Trousseau's syndrome, a thrombotic diathesis associated with cancer of pancreas, stomach, colon and rectum, lung, breast, ovary or prostate, producing mucin [4].Reviewing our old files, we found the case of a 67-year-old woman admitted with chronic intestinal constipation, asthenia, anorexia and weight loss, and recent progressive jaundice. Physical examination showed anicteric and malnourished patient, with a painful hard mass on the epigastrium. There was no feCoMMentAry ArtiCLe

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An Unusual Presentation of Streptococcus gallolyticus in Infective Endocarditis

Cruz,

Barkhordarian,

Antony

et al. 2023

Case Reports in Cardiology

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Background. Streptococcus gallolyticus (previously known as Streptococcus bovis type-1) bacteremia has a well-established, almost pathognomonic association with colorectal carcinoma, with the most common hypothesized mechanism being ulceration of polyps leading to hematologic dissemination. There are few reported cases of streptococcus bacteremia from other, seemingly benign sources like cellulitis or colonic adenomas. Hence, there is limited focus on skin and soft tissue infections leading to potentially fatal infective endocarditis. Case Presentation. We present a novel case of streptococcus bacteremia from uncommon sources like abdominal wall cellulitis or colonic adenoma leading to infective endocarditis as well as other manifestations, including osteomyelitis and discitis. This report highlights a unique case of streptococcus bacteremia with an uncommon origin, arising from abdominal wall cellulitis or colonic adenoma, ultimately resulting in the development of infective endocarditis. Furthermore, the patient presented with additional clinical manifestations, including osteomyelitis and discitis. Conclusions. Through our case report, we emphasize the importance of investigating uncommon sources like cellulitis when initial malignant workup is negative in streptococcus bacteremia and further elucidate the pathophysiology of streptococcus bacterial dissemination from nonmalignancy-related sources.

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Trousseau's syndrome due to asymptomatic pancreatic adenocarcinoma

Cited by 3 publications

References 13 publications

Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)

Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)

Pancreatic Adenocarcinoma: Role of the Site-Specific of Metastases

An Unusual Presentation of Streptococcus gallolyticus in Infective Endocarditis

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