TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases

Liu, Yusheng; Lyu, Yihan; Wang, Hongmei

doi:10.3389/fmolb.2022.895814

Cited by 14 publications

(5 citation statements)

References 242 publications

(346 reference statements)

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“…Both are regulated by PIP2 but differ in their high sensitivity to Ca2+. 92 TRPM4, identified as a homolog of MLSN (TRPM1), is highly expressed in the colon, prostate, kidney, and heart. 93 The c-terminal CaM binding site of TRPM4 is critical for susceptibility to Ca2±dependent activation.…”

Section: Activation Mechanisms Of the Trpm Channelsmentioning

confidence: 99%

Roles of TRPM channels in glioma

Chen,

Xie,

Liu

et al. 2024

Cancer Biology & Therapy

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Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. More and more studies have shown that TRPM channels can be used as new therapeutic targets for glioma. In this review, we first introduce the structure, activation patterns, and physiological functions of TRPM channels. Additionally, the pathological mechanism of glioma mediated by TRPM2, 3, 7, and 8 and the related signaling pathways are described. Finally, we discuss the therapeutic potential of targeting TRPM for glioma.

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Section: Activation Mechanisms Of the Trpm Channelsmentioning

confidence: 99%

Roles of TRPM channels in glioma

Chen,

Xie,

Liu

et al. 2024

Cancer Biology & Therapy

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“…TRP channels are expressed in various tissues, including the skeletal muscle, pancreas, liver, kidney, vascular endothelium, adipose tissue, and others. They have been linked to metabolic diseases such as obesity, diabetes, dyslipidemia, atherosclerosis, hypertension, and non-alcoholic fatty liver disease [7,8]. At present, numerous modulators of TRP channels have been documented to exert significant roles in the pathogenesis of metabolic diseases (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Role of TRP Channels in Metabolism-Related Diseases

Wu,

Bu,

Wang

2024

IJMS

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Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of associated diseases is of paramount importance. Transient Receptor Potential (TRP) channels, a type of nonselective cation channel, are expressed in a variety of tissues and have been implicated in the onset and progression of numerous metabolism-related diseases. This study aims to review and discuss the expression and function of TRP channels in metabolism-related tissues and blood vessels, and to elucidate the interactions and mechanisms between TRP channels and metabolism-related diseases. A comprehensive literature search was conducted using keywords such as TRP channels, metabolic syndrome, pancreas, liver, oxidative stress, diabetes, hypertension, and atherosclerosis across various academic databases including PubMed, Google Scholar, Elsevier, Web of Science, and CNKI. Our review of the current research suggests that TRP channels may be involved in the development of metabolism-related diseases by regulating insulin secretion and release, lipid metabolism, vascular functional activity, oxidative stress, and inflammatory response. TRP channels, as nonselective cation channels, play pivotal roles in sensing various intra- and extracellular stimuli and regulating ion homeostasis by osmosis. They present potential new targets for the diagnosis or treatment of metabolism-related diseases.

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“…), acid (H + ) and other biochemical factors (10). They also have an efferent function through local release of mediators such as neuropeptides (substance P [sP] and calcitonin gene related peptide [CGRP]) (11). TRPV1 + neurons are of known importance in pro-inflammatory reactions (12) and islet infiltrating lymphocytes express receptors for neuropeptides (13).…”

Section: Introductionmentioning

confidence: 99%

“…TRPV1 + neurons are of known importance in pro-inflammatory reactions (12) and islet infiltrating lymphocytes express receptors for neuropeptides (13). In this regard, it has been previously reported that NOD mice have a functional defect in sensory cells, particularly in those which express the TRPV1 receptor (11). Mutations in TRPV1 have also been related with T1D in humans (14).…”

Section: Introductionmentioning

confidence: 99%

NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development

et al. 2023

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IntroductionDuring the development of Autoimmune Diabetes (AD) an autoimmune attack against the Peripheral Nervous System occurs. To gain insight into this topic, analyses of Dorsal Root Ganglia (DRG) from Non-Obese Diabetic (NOD) mice were carried out.MethodsHistopathological analysis by electron and optical microscopy in DRG samples, and mRNA expression analyzes by the microarray technique in DRG and blood leukocyte samples from NOD and C57BL/6 mice were performed.ResultsThe results showed the formation of cytoplasmic vacuoles in DRG cells early in life that could be related to a neurodegenerative process. In view of these results, mRNA expression analyses were conducted to determine the cause and/or the molecules involved in this suspected disorder. The results showed that DRG cells from NOD mice have alterations in the transcription of a wide range of genes, which explain the previously observed alterations. In addition, differences in the transcription genes in white blood cells were also detected.DiscussionTaken together, these results indicate that functional defects are not only seen in beta cells but also in DRG in NOD mice. These results also indicate that these defects are not a consequence of the autoimmune process that takes place in NOD mice and suggest that they may be involved as triggers for its development.

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TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases

Cited by 14 publications

References 242 publications

Roles of TRPM channels in glioma

Roles of TRPM channels in glioma

Role of TRP Channels in Metabolism-Related Diseases

NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development

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