TRP channels: Emerging targets for respiratory disease

Banner, Katharine H.; Igney, Frederik H.; Poll, Chris

doi:10.1016/j.pharmthera.2011.03.005

Cited by 122 publications

(110 citation statements)

References 181 publications

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“…Although TRPA1 is predominantly expressed in sensory nociceptive neurons, TRPA1 gene expression has been demonstrated in non-neuronal cells, including epithelial, fibroblasts, B-cells, airway smooth muscle, CD4 + and CD8 + T-cells [108,109,110,124]. A role for TRPA1 has been demonstrated in murine models of allergic asthma utilising small molecule antagonists and TRPA1 −/− mice with an inhibitory effect on inflammatory mediator and mucus production, leukocyte infiltration and airway hyperresponsiveness (AHR) to acetylcholine [118].…”

Section: Trpa1mentioning

confidence: 99%

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi

Birrell

2017

Eur Respir J

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Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and increasing global health burden with a high unmet need. Drug discovery efforts in this area have been largely disappointing and so new therapeutic targets are needed. Transient receptor potential ion channels are emerging as possible therapeutic targets, given their widespread expression in the lung, their role in the modulation of inflammatory and structural changes and in the production of respiratory symptoms, such as bronchospasm and cough, seen in chronic lung disease.

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Section: Trpa1mentioning

confidence: 99%

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi

Birrell

2017

Eur Respir J

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“…1) C-fibres are sensitive to thermal and chemical stimulation, such as capsaicin, citric acid and hypertonic saline. TRPV1 and TRPA1 are C-fibre receptors that are very responsive to chemicals [20,21]. 2) RARs are rapidly responsive to mechanical stimulation, such as changes in, for example, diameter, length and compliance of the airways.…”

Section: Pathophysiology Of Chronic Coughmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. @ERSpublications Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH

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“…The biologic response to TRPV1 stimulation is consistent with respiratory disease symptoms and processes, including cough, bronchoconstriction, and inflammation. Moreover, cigarette smoke exposure, allergy, and virus cause hypersensitivity of the cough reflex to TRPV1 agonist inhalation, which can be prevented by TRPV1 antagonists (reviewed by Adcock, 2009, andBanner et al, 2011). Increased expression of TRPV1 in airway nerves and smooth muscle is also correlated with sensitization of the cough reflex in humans (Groneberg et al, 2004;Mitchell et al, 2005;Butler et al, 2010).…”

Section: B the G Protein-coupled Receptor-transient Receptor Potentimentioning

confidence: 99%

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Veldhuis¹,

Poole²,

Grace³

et al. 2014

Pharmacol Rev

142

135

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TRP channels: Emerging targets for respiratory disease

Cited by 122 publications

References 181 publications

The emerging role of transient receptor potential channels in chronic lung disease

The emerging role of transient receptor potential channels in chronic lung disease

Cough in idiopathic pulmonary fibrosis

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

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