TRP Channels in Skin Biology and Pathophysiology

Caterina, Michael J.; Pang, Zixuan

doi:10.3390/ph9040077

Cited by 137 publications

(138 citation statements)

References 221 publications

(289 reference statements)

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“…Transient receptor potential (TRP) channels are a superfamily of ion channels that consists of 28 cation channels (1). This superfamily of TRP channels is termed after the trp gene in Drosophila that upon mutation leads to a transient receptor potential following light exposure.…”

Section: The Trp Superfamily and Trpv1mentioning

confidence: 99%

Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin

Maiese

2017

CNR

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BACKGROUND Transient receptor potential (TRP) channels are a superfamily of ion channels termed after the trp gene in Drosophila that are diverse in structure and control a wide range of biological functions including cell development and growth, thermal regulation, and vascular physiology. Of significant interest is the transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, also known as the capsaicin receptor and the vanilloid receptor 1, that is a non-selective cation channel sensitive to a host of external stimuli including capsaicin and camphor, venoms, acid/basic pH changes, and temperature. METHODS Given the multiple modalities that TRPV1 receptors impact in the body, we examined and discussed the role of these receptors in vasomotor control, metabolic disorders, cellular injury, oxidative stress, apoptosis, autophagy, and neurodegenerative disorders and their overlap with other signal transduction pathways that impact trophic factors. RESULTS Surprisingly, TRPV1 receptors do not rely entirely upon calcium signaling to affect cellular biology, but also have a close relationship with the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), and protein kinase B (Akt) that have roles in pain sensitivity, stem cell development, cellular survival, and cellular metabolism. These pathways with TRPV1 converge in the signaling of growth factors with recent work highlighting a relationship with erythropoietin (EPO). Angiogenesis and endothelial tube formation controlled by EPO requires, in part, the activation of TRPV1 receptors in conjunction with Akt and AMPK pathways. CONCLUSIONS TRPV1 receptors could prove to become vital to target disorders of vascular origin and neurodegeneration. Broader and currently unrealized implementations for both EPO and TRPV1 receptors can be envisioned for for the development of novel therapeutic strategies in multiple systems of the body.

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Section: The Trp Superfamily and Trpv1mentioning

confidence: 99%

Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin

Maiese

2017

CNR

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“…Especially involved are receptors from the family of transient receptor proteins (TRPs) 42,43 and others. It can be explained by the activation or rather the hyper-activation of proteins present on the surface of keratinocytes and intra-epidermal nerve endings.…”

Section: Biochemical Role Of Sensory Proteins Including Trpmentioning

confidence: 99%

Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)

Miséry

Weißhaar

Brenaut

et al. 2019

Acad Dermatol Venereol

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The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skinas well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. Emotion1.77 1. 44-2.17 Comparison between people with sensitive skin and healthy subjects. Results from a meta-analysis.

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“…TRPV 4 is activated by heat, mechanical, hyperosmotic and stress. TRPM 8 is activated by cold, menthol, wasabi and mustard and while TRPA 1 is activated by cold, wasabi, mustard, horseradish and bradykinin [23][24][25][26][27].…”

Section: Trp Channelsmentioning

confidence: 99%

Sensitive Skin Syndromes and Transient Receptors Potential (TRP) Channels in Sensitive Skin

2018

IJCED

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Sensitive skin is a prevalent skin condition affecting both female and male worldwide without the presence of perceivable signs. The associations between sensitive skin and pre-existing skin diseases of atopy and dermatitis, dry skin, rosacea and food hypersensitivity in the gut with cognitive complications are referred to as Sensitive Skin Syndrome (SSS), making this disease more complex. Neurogenic and non-neurogenic inflammation, epidermal barrier defects, TRP ions channels interplay with the central nervous system combining with subsequent perceptive cognitive motor behaviour appears to be the main pathogenetic mechanism. Further research and studies of this intriguing condition may further enlighten us on how different systems of the body: skin, nervous system, cognition and gut integrate functionally and pathologically as a whole. and France in studies employing different methodologies. Reactive skin, over reactive skin, intolerant skin and irritable skin were used

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TRP Channels in Skin Biology and Pathophysiology

Cited by 137 publications

References 221 publications

Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin

Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin

Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI)

Sensitive Skin Syndromes and Transient Receptors Potential (TRP) Channels in Sensitive Skin

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