TRP Channels in the Brain

Reboreda, Antonio

doi:10.1007/978-1-62703-095-3_7

Cited by 2 publications

(2 citation statements)

References 198 publications

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“…Abbreviations: 2-APB, 2-aminoethoxydiphenyl borate; CA1, Cornu Ammonis 1; DEE, developmental and epileptic encephalopathies; DHEA, dehydroepiandrosterone; DRG, dorsal root ganglia; GABA, γ-aminobutyric acid; Gβγ, G beta-gamma complex; GIRK, G-protein-coupled inward rectifier potassium channel; ICFR, region indispensable for channel f unctions in TRPM3; I-V plot, current-voltage plot; KS, Kabuki syndrome; K v , voltage-gated potassium channel; MCA/MR, multiple congenital anomaly/mental retardation syndrome; MITF, microphthalmia/melanogenesis-associated transcription factor; N.at-K v 3.2, flatworm voltage-gated potassium channel 3; Na v , voltage-gated sodium channel; NFATc1, nuclear factor of activated T cells type c1; NMDA, N-methyl-D-aspartate; Pax6, paired-box 6 transcription factor; PD, pore domain; PtdIns(4,5)P 2 , phosphatidylinositol 4,5-bisphosphate; PtdIns(3,4,5)P 3 , phosphatidylinositol 3,4,5-trisphosphate; PregS, pregnenolone sulfate; RANKL, receptor activator of nuclear factor kappa-B ligand; S1-6, transmembrane segments 1-6; STS, steroid sulfatase; TRPM, transient receptor potential channel melastatin; TRPC, transient receptor potential channel canonical; TRPV, transient receptor potential channel vanilloid; VM/PQ mutation, human TRPM3 DEE point mutations with amino acid substitutions valine to methionine (VM) and proline to glutamine (PQ); VSD, voltage-sensing domain; WT, wild type. Some members of the TRP channel family are functionally expressed in various brain regions and their involvement in diverse physiological and pathological processes of the brain has already been described (Moran et al, 2004;Nilius, 2012;Reboreda, 2012;Sawamura et al, 2017). Among them, the TRP canonical (TRPC) channel subfamily presents probably the moststudied TRP channel subfamily in the brain (Sawamura et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Some members of the TRP channel family are functionally expressed in various brain regions and their involvement in diverse physiological and pathological processes of the brain has already been described (Moran et al, 2004 ; Nilius, 2012 ; Reboreda, 2012 ; Sawamura et al, 2017 ). Among them, the TRP c anonical (TRPC) channel subfamily presents probably the most-studied TRP channel subfamily in the brain (Sawamura et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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TRPM3 in Brain (Patho)Physiology

Held

Tóth

2021

Front. Cell Dev. Biol.

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Already for centuries, humankind is driven to understand the physiological and pathological mechanisms that occur in our brains. Today, we know that ion channels play an essential role in the regulation of neural processes and control many functions of the central nervous system. Ion channels present a diverse group of membrane-spanning proteins that allow ions to penetrate the insulating cell membrane upon opening of their channel pores. This regulated ion permeation results in different electrical and chemical signals that are necessary to maintain physiological excitatory and inhibitory processes in the brain. Therefore, it is no surprise that disturbances in the functions of cerebral ion channels can result in a plethora of neurological disorders, which present a tremendous health care burden for our current society. The identification of ion channel-related brain disorders also fuel the research into the roles of ion channel proteins in various brain states. In the last decade, mounting evidence has been collected that indicates a pivotal role for transient receptor potential (TRP) ion channels in the development and various physiological functions of the central nervous system. For instance, TRP channels modulate neurite growth, synaptic plasticity and integration, and are required for neuronal survival. Moreover, TRP channels are involved in numerous neurological disorders. TRPM3 belongs to the melastatin subfamily of TRP channels and represents a non-selective cation channel that can be activated by several different stimuli, including the neurosteroid pregnenolone sulfate, osmotic pressures and heat. The channel is best known as a peripheral nociceptive ion channel that participates in heat sensation. However, recent research identifies TRPM3 as an emerging new player in the brain. In this review, we summarize the available data regarding the roles of TRPM3 in the brain, and correlate these data with the neuropathological processes in which this ion channel may be involved.

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