TRPM7 deficiency suppresses cell proliferation, migration, and invasion in human colorectal cancer via regulation of epithelial-mesenchymal transition

Su, Fei; Wang, Bofang; Zhang, Tao; Hou, Xiaoming; Mao, Feng

doi:10.3233/cbm-190666

Cited by 19 publications

(17 citation statements)

References 20 publications

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“…How inhibition of TRPM7 exerts the observed effects, such as the inhibition of EndoMT, proliferation, and vasorelaxation, remains unclear. TRPM7 has been reported to contribute to the epithelial-mesenchymal transition in ovarian, prostate, colorectal and breast cancers [28][29][30][31][32][33]. Ca 2+ influx and the subsequent activation of STAT3 or Akt in breast and ovarian cancers, respectively, and Mg 2+ influx in prostate cancer have been suggested to support the TRPM7-mediated epithelial-mesenchymal transition [28,29,32].…”

Section: Discussionmentioning

confidence: 99%

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension

Hiraishi

Kurahara

Feng

et al. 2021

Translational Research

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension

Hiraishi

Kurahara

Feng

et al. 2021

Translational Research

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“…The downregulation of TRPM7 suppressed CRC cell proliferation, migration, and invasion, as well as triggered cell cycle arrest in the G0/G1 phase, reduced the S phase, and promoted apoptosis. Furthermore, the decrease in TRPM7 expression in CRC cells reversed EMT, which was accompanied by a downregulation in N-cadherin and an upregulation of E-cadherin expression [151]. Mg 2+ homeostasis regulation via TRPM6 and TRPM7 was also linked to the sensitivity of CRC cells to doxorubicin, a common chemotherapeutic agent.…”

Section: Colorectal Cancermentioning

confidence: 93%

“…Indeed, it was reported that TRPM6 is downregulated in CRC tissues on mRNA level [120,123], and its higher expression is correlated with an increased overall survival [123]. On the other hand, TRPM7 was suggested to be upregulated in CRC on mRNA level [151]. Moreover, a single-nucleotide polymorphism that substitutes TRPM7 threonine 1482 for isoleucine (T1482I) increases the risk of the development of colon cancer, particularly in patients with a high Ca 2+ /Mg 2+ ratio [152].…”

Section: Colorectal Cancermentioning

confidence: 99%

TRP Channels in Digestive Tract Cancers

Stokłosa

Borgström

Kappel

et al. 2020

IJMS

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

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“…Furthermore, Huang et al show that the TRPM7 channel is the main transporter for Mg 2+ influx in both the HT-29 CRC cell line and in primary mouse colon epithelial cells. Su et al also show that TRPM7 silencing decreases both HT-29 and SW-480 cell proliferation, migration and invasion [82]. Inhibition of TRPM7 induces the upregulation of E-cadherin and the downregulation of N-cadherin in CRC cells suggesting that this channel may regulate epithelial-to-mesenchymal transition (EMT).…”

Section: Regulation Of Digestive Cancer Cell Fates By Magnesium Transportersmentioning

confidence: 97%

“…TRPM7 was also found upregulated in CRC using in silico datasets but also qRT-PCR, immunofluorescence, and IHC on tissues. TRPM7 expression was also associated with tumor infiltration, tumor grade, and the presence of distant metastasis [81,82]. In qRT-PCR-based and in silico studies, the Mg 2+ transporter MAGT1 was found to be overexpressed in colorectal cancerous tissues [83].…”

Section: Analysis Of the Literaturementioning

confidence: 99%

Mg2+ Transporters in Digestive Cancers

et al. 2021

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Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.

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TRPM7 deficiency suppresses cell proliferation, migration, and invasion in human colorectal cancer via regulation of epithelial-mesenchymal transition

Cited by 19 publications

References 20 publications

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension

TRP Channels in Digestive Tract Cancers

Mg2+ Transporters in Digestive Cancers

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