TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma

Chen, Jianpeng; Wang, Jun; Luan, Yi; Wang, Caixia; Li, Wenhuan; Zhang, Jinbiao; Sha, Dan; Shen, Rong; Cui, Yangang; Zheng, Zhen; Zhang, Liming; Wang, Weibo

doi:10.1016/j.canlet.2014.09.032

Cited by 33 publications

(25 citation statements)

References 34 publications

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“…Several studies have reported the involvement of TRPM7 in cell migration and invasion induced by fetal calf serum (FCS) as chemoattractant in breast [18], [26], nasopharyngeal [20], [21], and pancreatic cancer cells [25]. In our work, it is important to note that we do not use any stimulation (by chemotaxis or activator) to promote cell invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Among TRP channels, the transient receptor potential melastatin related 7 (TRPM7) channel is a Ca 2+ /Mg 2+ channel fused with a functional kinase domain that belongs to the α-kinase family [13], [14]. We and others showed that TRPM7 is involved in migration and/or invasion of epidermal cancer cells including neuroblastoma [15], [16], glioblastoma [17], breast cancer [18], [19], nasopharynx cancer [20], [21], lung cancer [22], prostate cancer [23], and PDAC [24], [25]. Importantly, TRPM7 is required for breast cancer metastasis formation in mouse xenograft, and high channel expression is an independent marker of poor outcome in breast cancer patients [26].…”

Section: Introductionmentioning

confidence: 99%

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The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

et al. 2017

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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor prognosis. There is an urgent need to better understand the molecular mechanisms that regulate PDAC cell aggressiveness. The transient receptor potential melastatin 7 (TRPM7) is a nonselective cationic channel that mainly conducts Ca2+ and Mg2+. TRPM7 is overexpressed in numerous malignancies including PDAC. In the present study, we used the PANC-1 and MIA PaCa-2 cell lines to specifically assess the role of TRPM7 in cell invasion and matrix metalloproteinase secretion. We show that TRPM7 regulates Mg2+ homeostasis and constitutive cation entry in both PDAC cell lines. Moreover, cell invasion is strongly reduced by TRPM7 silencing without affecting the cell viability. Conditioned media were further studied, by gel zymography, to detect matrix metalloproteinase (MMP) secretion in PDAC cells. Our results show that MMP-2, urokinase plasminogen activator (uPA), and heat-shock protein 90α (Hsp90α) secretions are significantly decreased in TRPM7-deficient PDAC cells. Moreover, TRPM7 expression in human PDAC lymph node metastasis is correlated to the channel expression in primary tumor. Taken together, our results show that TRPM7 is involved in PDAC cell invasion through regulation of Hsp90α/uPA/MMP-2 proteolytic axis, confirming that this channel could be a promising biomarker and possibly a target for PDAC metastasis therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

et al. 2017

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“…Later, changes in the expression level of TRPM4 were found to be important for the proliferation of the prostate cancer cells in the androgenindependent phase and cervical cancer-derived HeLa cells [172][173][174]. However the majority of evidence in the TRPM family concentrates on the TRPM7 channel, which is implicated in enhancing proliferative potential of the grade III breast tumour cells [175] as well as participating in gastric and pancreatic cancers [176][177][178], human hypopharyngeal squamous cell and nasopharyngeal carcinomas [179,180], prostate cancer [181] and enhances invasive properties of neuroblastoma [182][183][184].…”

Section: Pro-proliferative Role Of Trpsmentioning

confidence: 97%

Functional and physiopathological implications of TRP channels

Smani

Shapovalov

Skryma

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins that are expressed in many organisms, tissues and cell types. TRP channels respond to a variety of stimuli, including light, mechanical or chemical stimuli, temperature, pH or osmolarity. In addition, several TRP family members have been identified as downstream molecules in the G protein-coupled receptor signaling pathway. TRP proteins are involved in a variety of cell functions both in non-excitable and excitable cells due to their diverse permeability to cations and their ability to modulate intracellular Ca2+ signaling. Emerging evidence suggests that TRP channel dysfunction significantly contributes to the physiopathology of a number of diseases, including cardiovascular, neurological, metabolic or neoplastic disorders. This review focuses on the implication of TRP proteins in the pathogenesis of some of the most prevalent disorders in human. We summarize the current findings regarding the role of TRP proteins in the development of cardiovascular disease, diabetes mellitus as well as diabetic complications, and tumorigenesis and present TRP proteins as targets of potential diagnostic and therapeutic strategies.

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Section: Trp Channels In Cancer Metastasismentioning

confidence: 99%

“…In nasopharyngeal cancer, the increased expression of TRPM7 is associated with poor prognosis and metastasis (67). Similar to breast cancer cells, silencing of TRPM7 decreases the migration and invasion of metastatic cancer cells, and also the overexpression of TRPM7 increases both phenomena in nonmetastatic cancer cells (67). The contribution of TRPM7 to migration of human nasopharyngeal cancer cells is attributed to ryanodine receptor (RyR) activation, which consequently increases [Ca 2+ ]i levels and cellular migration (68).…”

Section: Trp Channels In Cancer Metastasismentioning

confidence: 99%

Emerging role of transient receptor potential (TRP) channels in cancer progression

Yang

Kim

2020

BMB Rep.

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Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca 2+ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca 2+ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer. [BMB Reports 2020; 53(3): 125-132]

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TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma

Cited by 33 publications

References 34 publications

The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway

Functional and physiopathological implications of TRP channels

Emerging role of transient receptor potential (TRP) channels in cancer progression

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