TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer

Ai, Di; Yao, Jun; Yang, Fei; Huo, Lei; Chen, Hui; Lü, Wei; Soto, Luisa M. Solis; Jiang, Mei; Raso, Maria Gabriela; Wang, Shufang; Bell, Diana; Liu, Jinsong; Wang, Huamin; Tan, Dongfeng; Torres‐Cabala, Carlos A.; Gan, Qiong; Wu, Yun; Albarracin, Constance T.; Hung, Mien‐Chie; Meric‐Bernstam, Funda; Wistuba, Ignacio I.; Prieto, Víctor G.; Şahin, Ayşegül; Ding, Qingqing

doi:10.1038/s41379-020-00692-8

Cited by 141 publications

(223 citation statements)

References 31 publications

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“…20,30 Our findings and recent study suggest that TRPS1 is a highly sensitive and specific marker to confirm breast origin and can be used as a great diagnostic tool, especially for TNBC including metaplastic BC. 14 In summary, this study has significantly expanded our knowledge of TRPS1 expression in BCs, especially metaplastic carcinomas, which usually lack good markers. Furthermore, we have also documented TRPS1's expression in normal breast ductal epithelial cells and TRPS1's potential cross-reactivity with HER2 protein.…”

Section: Discussionmentioning

confidence: 79%

“…A recent study has demonstrated that TRPS1 is a highly sensitive and specific marker for BCs with comparable positive expression to GATA3 in ER + and HER2 + BCs, but significantly higher expression than GATA3 in TNBCs using TMAs. 14 To further explore TRPS1's utility in BCs, we systematically evaluated TRPS1 expression in 160 ER + /HER2 + BCs, 94 ER − /HER2 + BCs, 117 TNBCs, and 618 other primary carcinomas including 93 endometrial carcinomas, 109 cholangiocarcinomas, 208 colorectal adenocarcinomas, and 208 hepatocellular carcinomas by IHCs on TMAs. Furthermore, we performed TRPS1 IHC on whole tissue sections from 64 HER2 + BCs, 76 TNBCs, and 67 invasive metaplastic BCs and compared its expression with GATA3.…”

Section: Discussionmentioning

confidence: 99%

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TRPS1 Expression in Breast Carcinomas

Parkinson

Chen

Shen

et al. 2021

American Journal of Surgical Pathology

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TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we systematically evaluated TRPS1 expression on tissue microarrays from 160 estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)positive, 94 ER − /HER2 + , 117 triple-negative breast carcinomas, and 618 other primary carcinomas (cholangiocarcinoma, endometrial, colorectal, and hepatocellular carcinomas), and whole tissue sections from 64 HER2 + , 76 triple-negative, and 67 metaplastic breast carcinomas. The results showed TRPS1 was highly expressed in breast carcinomas (100% of HER2 + and 97.4% of triple negative on whole tissue sections), but almost completely negative in other

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

TRPS1 Expression in Breast Carcinomas

Parkinson

Chen

Shen

et al. 2021

American Journal of Surgical Pathology

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“…In addition, ultrasound endoscopy can also determine the cystic solidity of the tumour by its echogenicity [ 12 ]. In addition, ultrasound endoscopy can also determine the cystic solidity of the tumour by its echogenicity, thus further differentiating it from some other gastric tumours [ 13 ]. However, the application of RECIST morphological criteria based only on the change of tumour size does not accurately reflect the effect of tumour treatment, and there are limitations in using it to evaluate the targeted treatment of gastrointestinal mesenchymal tumours [ 14 ].…”

Section: Related Workmentioning

confidence: 99%

Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

Yang

Zhang

et al. 2021

Journal of Healthcare Engineering

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This paper presents an in-depth analysis and study of the diagnostic effectiveness of EUS-RTE in giant cystic tumours of the oesophagus utilizing cluster analysis. A new form of interval data expression was designed based on the cluster analysis algorithm, as well as a new way of updating the cluster radius and cluster centre. Feature triads are defined, eliminating the need to access all historical data at the time of update. It also prevents the case of overfusion of clusters and outputting only one cluster. If there exist a very low number of clusters, the newly merged clusters are reclustered according to the density clustering method for the internal data objects based on the cluster segmentation so that the data objects in the same cluster have a high similarity as possible. All accumulated electronic files of oesophageal cancer cases were collected and comprehensively organized, and all clinical data of 129 eligible cases with a total of 356 consultations were screened in strict accordance with inclusion and exclusion criteria. A database of oesophageal cancer cases was established using Visual FoxPro software, and frequency distribution, cluster analysis, association rule, and chi-square test were used to focus on mining the association between symptoms, disease mechanisms, prescriptions, and medications. The results were analysed and summarized. Overall, the therapeutic efficacy and safety of the three groups of treatment modalities for gastric mesenchymal tumours were positive, and the preoperative endoscopic treatment modalities should be selected based on the EUS-RTE characteristics of the tumour, the site, and the operator’s skill level in a comprehensive manner.

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“…24 In light of these difficulties, Di et al proposed the transcription factor TRPS1 as a novel biomarker for TN MpBCs, being expressed in 86% of cases relative to GATA3's 21%. 21 Genetic analysis of the patient's breast mass indicated mutations inCDH1 , raising alarm. This gene encodes E-cadherin, a transmembrane glycoprotein that maintains cell-cell adhesion.…”

Section: Discussionmentioning

confidence: 99%