True hermaphroditism

Walker, Andrew; Walker, JL; Adams, Sarah; Shi, Enyi; McGlynn, Michael; Verge, CF

doi:10.1046/j.1440-1754.2000.00432.x

Cited by 20 publications

(14 citation statements)

References 20 publications

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“…The most common karyotype was 46,XX, constituting 61.6% of patients in the present study and reviewed cases from Japan. This finding was consistent with the published literature from other countries 2,3,11 . A large review of ovotesticular DSD has shown geographic variations 3 .…”

Section: Discussionsupporting

confidence: 92%

“…The female : male ratio as the sex of rearing was 1:1 in the present study, similar to findings from a previous review 3,11 . Surgery is generally necessary after gender assignment.…”

Section: Discussionsupporting

confidence: 91%

“…In our review of data from Japan, the most common gonad was ovotestis, followed by ovary and testis as has already been described in other ethnicities. 3,11 However, the frequency of testis was higher in Japan than in other ethnici-ties (20.7% vs 12.5%, respectively). 3 This difference might be explained by the high incidence of the Y chromosome in Japan.…”

Section: Discussionmentioning

confidence: 93%

“…This finding was consistent with the published literature from other countries. 2,3,11 A large review of ovotesticular DSD has shown geographic variations. 3 In the largest review, the 46,XX karyotype was reported as being particularly frequent in South and Western Africa, whereas chromosomal mosaicism containing the Y chromosome is relatively common in Europe and North America, and 46,XY is equally distributed over Asia, Europe and North America.…”

Section: Discussionmentioning

confidence: 99%

“…The female : male ratio as the sex of rearing was 1:1 in the present study, similar to findings from a previous review. 3,11 Surgery is generally necessary after gender assignment. This includes removal of gonads and internal ducts inappropriate to the sex of rearing, and genitoplasty to construct the appropriate external appearance.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term outcome of ovotesticular disorder of sex development: A single center experience

Matsui¹,

Shimada²,

Matsumoto³

et al. 2011

Int J of Urology

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Objectives:To describe the clinical features of children with ovotesticular disorder of sex development (DSD) and to review cases of ovotesticular DSD in Japan. Methods: Medical records of eight children diagnosed with ovotesticular DSD at our institute during the past 17 years were retrospectively evaluated. A review of 165 reported cases of ovotesticular DSD from Japanese institutions was carried out. Results: Mean follow up was 8.2 years for six children, with two children lost to follow up. Mean age at first presentation was 2.4 months. All children were Japanese. The most common initial manifestation was ambiguous genitalia. The female-: male ratio as the sex of rearing was 1:1. Gender reassignment, from male to female, was carried out in one child at 4-months-old. Genital surgery was always carried out in early childhood as per family desire. Appropriate gonadal tissue was preserved except for one child. No gonadal tumors were detected during follow up. Spontaneous pubertal development occurred in one boy. In reviewing Japanese data, the frequency of testes was higher than in other ethnicities and this was related to the higher incidence of 46,XY. Conclusions: According to our experience, most families in Japan desire early genital surgery in the case of ovotesticular DSD. Chromosomal and gonadal distributions in patients with ovotesticular DSD differ between Japanese and other ethnic groups. Treatment for these patients needs to be provided after considering the cultural and social backgrounds of DSD in Japan.

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Section: Discussionsupporting

confidence: 92%

“…The female : male ratio as the sex of rearing was 1:1 in the present study, similar to findings from a previous review 3,11 . Surgery is generally necessary after gender assignment.…”

Section: Discussionsupporting

confidence: 91%