Applying the data encryption method used in conventional personal computers (PC) to wireless communication devices such as IoT is not trivial. Because IoT equipment is extremely slow in transferring data and has a small hardware area compared with PCs, it is difficult to transfer large data and perform complicated operations. In particular, it is difficult to apply the RSA encryption method to wireless communication devices because it guarantees the stability of data encryption because it is difficult to factor extremely large prime numbers. Furthermore, it has become even more difficult to apply the RSA encryption method to IoT devices as a paper recently published indicated that it enables rapid fractional decomposition when using RSA encryption with a prime number generated through several pseudo-random number generators. To compensate for the disadvantages of RSA encryption, we propose a method that significantly reduces the encryption key using a true prime random number generator (TPRNG), which generates a prime number that cannot be predicted through bio-signals, and a disposable RSA encryption key. TPRNG has been verified by the National Institute of Standards and Technology. The NIST test and an RSA algorithm are implemented through Verilog.